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Acta Diabetologica
Published in: Acta Diabetologica 5/2013

01-10-2013 | Review Article

Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis

Authors: Hui Li, Xiaojun Tang, Qin Liu, Yang Wang

Published in: Acta Diabetologica | Issue 5/2013

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Abstract

To assess the association between type 2 diabetes and rs10811661 polymorphism, upstream of CDKN2A/B, a literature-based search was conducted to collect data. The pooled OR (odds ratio) and 95 % confidence intervals (CI) were used to assess the strength of association between rs10811661 polymorphism and type 2 diabetes. OR with 95 % CI were performed for allele contrasts, additive genetic model, dominant genetic model and recessive genetic model, respectively. The effect model was used if there was heterogeneity between studies. Funnel plots were used to predict publication bias. 17 studies with 29,990 cases and 40,977 controls were enrolled in this meta-analysis. Significant association was found in all of the four genetic models: allele contrast (OR = 1.21, 95 % CI 1.18–1.24), additive genetic model (OR = 1.51, 95 % CI 1.40–1.63), dominant genetic model (OR = 1.37, 95 % CI 1.28–1.47) and recessive genetic model (OR = 1.25, 95 % CI 1.21–1.29). The meta-analysis indicated that rs10811661 polymorphism was significantly associated with the risk of type 2 diabetes.
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Metadata
Title
Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis
Authors
Hui Li
Xiaojun Tang
Qin Liu
Yang Wang
Publication date
01-10-2013
Publisher
Springer Milan
Published in
Acta Diabetologica / Issue 5/2013
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-012-0400-7

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