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Open Access 01-10-2015

Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism

Authors: Judith Kooiman, Paul L. den Exter, Inci Kilicsoy, Suzanne C. Cannegieter, Jeroen Eikenboom, Menno V. Huisman, Frederikus A. Klok, Henri H. Versteeg

Published in: Journal of Thrombosis and Thrombolysis | Issue 3/2015

Abstract

Studies on the association between microparticle expressing tissue factor (MP-TF) activity, FVIII activity (FVIII:C) and recurrent VTE yielded inconclusive results. We studied these associations in patients diagnosed with acute pulmonary embolism. Plasma levels of MP-TF and FVIII activity were measured in 277 patients with a first and 72 patients with a recurrent VTE. All patients were categorized based on the quintiles of MP-TF and FVIII activity in those with a single VTE. For both markers, odds ratios (ORs) for recurrent VTE were computed using patients in the lowest quintile as a reference group. No association was observed between MP-TF activity and recurrent VTE, with an OR of 1.4 (95 % CI 0.7–2.9) in the highest quintile of MP-TF activity. Compared with the reference group, patients in the highest quintile of FVIII:C were at increased risk of recurrent VTE, OR 4.2 (95 % CI 1.4–12.2). MP-TF activity was not associated with recurrent VTE whereas high FVIII:C levels were associated with a 4-fold increased risk of VTE recurrence. Future prospective studies are necessary to explore the potential of FVIII:C as a tool for risk stratification, either by itself or in combination with other pro-thrombotic markers.

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Title: Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism
Authors: Judith Kooiman
Paul L. den Exter
Inci Kilicsoy
Suzanne C. Cannegieter
Jeroen Eikenboom
Menno V. Huisman
Frederikus A. Klok
Henri H. Versteeg
Publication date: 01-10-2015
Publisher: Springer US
Published in: Journal of Thrombosis and Thrombolysis / Issue 3/2015
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-015-1180-z

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