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European Journal of Nutrition
Published in: European Journal of Nutrition 8/2022

27-07-2022 | Original Contribution

Association between coffee consumption with serum lipid profile in ELSA-Brasil study: a metabolomic approach

Authors: Andreia Machado Miranda, Alessandra Carvalho Goulart, Giuliano Generoso, Márcio Sommer Bittencourt, Raul Dias Santos, Peter P. Toth, Stevens R. Jones, Isabela M. Benseñor, Paulo A. Lotufo, Dirce Maria Marchioni

Published in: European Journal of Nutrition | Issue 8/2022

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Abstract

Purpose

This study evaluated the association between coffee consumption and serum lipid profile in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Methods

This is a cross-sectional study on baseline data from participants of the cohort ELSA-Brasil. Only participants of São Paulo Research Center who underwent a nuclear magnetic resonance (NMR) spectroscopy examination of lipid profile were included (N = 4736). Coffee intake was categorized into four categories (cups/day, in reference cup size of 50 mL, which is the household measure adopted in Brazil): never/almost never, ≤ 1, 1–3, and > 3. Serum lipid profile [i.e., Total Cholesterol (TC), Total Triglycerides (TG), Very Low-Density Lipoprotein-cholesterol (VLDL-c), Low-Density Lipoprotein-cholesterol (LDL-c), High-Density Lipoprotein-cholesterol (HDL-c), Triglyceride-rich Lipoprotein Particles (TRLP) and subfractions particles] was analyzed. To estimate the effect of coffee consumption on serum lipid profile, multivariate Generalized Linear Models were performed.

Results

Compared to participants who never or almost never drink coffee, individuals who consumed more than 3 cups/day showed an increase in concentrations of TC (β: 4.13; 95% CI 0.81, 7.45), TG (β: 9.53; 95% CI 1.65, 17.42), VLDL-c (β: 1.90; 95% CI 0.38, 3.42), TRLP (β: 8.42; 95% CI 1.24, 15.60), and Very Small-TRLP and Medium-TRLP subfractions (β: 7.36; 95% CI 0.21, 14.51; β: 2.53; 95% CI 0.89, 4.16, respectively), but not with HDL-c and LDL-c. Among individuals with low (≤ 1 cup/day) and moderate (1–3 cups/day) coffee consumption, no significant associations with lipids was observed.

Conclusion

High coffee consumption (more than 3 cups per day) was associated with an increase in serum lipids, namely TC, TG, VLDL-c, and TRL particles, highlighting the importance of a moderate consumption of this beverage.
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Metadata
Title
Association between coffee consumption with serum lipid profile in ELSA-Brasil study: a metabolomic approach
Authors
Andreia Machado Miranda
Alessandra Carvalho Goulart
Giuliano Generoso
Márcio Sommer Bittencourt
Raul Dias Santos
Peter P. Toth
Stevens R. Jones
Isabela M. Benseñor
Paulo A. Lotufo
Dirce Maria Marchioni
Publication date
27-07-2022
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 8/2022
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-022-02946-4

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