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Japanese Journal of Ophthalmology

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01-01-2020 | Clinical Investigation

Association between axial length and in vivo human crystalline lens biometry during accommodation: a swept-source optical coherence tomography study

Authors: Takuhei Shoji, Naoko Kato, Sho Ishikawa, Hisashi Ibuki, Norihiro Yamada, Itaru Kimura, Kei Shinoda

Published in: Japanese Journal of Ophthalmology | Issue 1/2020

Abstract

Purpose

To evaluate the association between axial length and crystalline lens biometry with and without accommodation using the CASIA2 swept-source (SS) optical coherence tomography (OCT) system on the anterior segment.

Study design

Intervention study.

Methods

Individuals aged 20 to 39 years were enrolled for SS-OCT imaging at 2 separate visits within 1 week. Each eye was imaged under accommodation stimuli with different amplitudes (0 D, -1 D, -3 D, -5 D, and -7 D). The anterior and posterior lens curvature radii and lens thicknesses were measured. The participants were divided into 4 groups according to axial length.

Results

Forty-eight participants (96 eyes) were initially enrolled. All 96 eyes were included in the analyses, as they met the eligibility criteria and each had proper OCT images. The mean participant age was 25.9 ± 4.3 years, and the mean spherical error was -3.5 ± 2.5 D. The mean axial length was 25.1 ± 1.2 mm. Multivariate analysis revealed that the anterior curvature radius became flatter and the lens thickness became thicker as the axial length increased (all P < .01). Furthermore, axial length independently contributed to the shape of the lens after adjusting for the effects of age and accommodation stimuli.

Conclusion

Axial length was associated with lens shape after adjusting for age and accommodation stimuli. These measurements can provide a glimpse of dynamic lens biometry changes, which may help us better understand the role of lenses in various physiologic changes, including accommodation and myopia.

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Title: Association between axial length and in vivo human crystalline lens biometry during accommodation: a swept-source optical coherence tomography study
Authors: Takuhei Shoji
Naoko Kato
Sho Ishikawa
Hisashi Ibuki
Norihiro Yamada
Itaru Kimura
Kei Shinoda
Publication date: 01-01-2020
Publisher: Springer Japan
Published in: Japanese Journal of Ophthalmology / Issue 1/2020
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-019-00700-8

At a glance: The STEP trials

Springer Medicine

Association between axial length and in vivo human crystalline lens biometry during accommodation: a swept-source optical coherence tomography study

Abstract

Purpose

Study design

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Study design

Methods

Results

Conclusion

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