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03-05-2024

Association between adverse childhood experiences and health related quality of life in adult cancer survivors in the United States

Authors: Emily C. Merkel, Daron M. Vandeleur, Xin Cheng, Alyson J. Littman, K. Scott Baker

Published in: Journal of Cancer Survivorship

Abstract

Purpose

The impact of adverse childhood experiences (ACEs) on health-related quality of life (HRQOL) is increasingly recognized, however, this has not been studied in cancer survivors in the United States. This study investigates if ACEs are associated with HRQOL in cancer survivors.

Methods

We conducted a cross-sectional analysis of the 2020 Behavioral Risk Factor Surveillance System from states that administered ACEs and Cancer Survivorship modules. Eligibility criteria included being a cancer survivor and not currently receiving cancer treatment. Primary exposure was number of ACEs (categorized as 0, 1–2, 3, or ≥ 4). Primary outcomes were self-reported measures of HRQOL including worse overall health and ≥ 14 unhealthy days (mentally or physically) per month. Mantel-Haenszel stratified analyses were performed and prevalence ratios were adjusted for age.

Results

Of 5,780 participants, 62.0% were female and 67.8% were ≥ 65 years. Prevalence of worse overall health was 22.5% for individuals with no ACEs compared to 30.2% for 2–3 ACEs (aPR = 1.4, 95% CI 1.2, 1.5) and 38.5% for ≥ 4 ACEs (aPR = 1.7, 95% CI 1.5, 2.0). Prevalence of ≥ 14 unhealthy days was 18.1% with no ACEs compared to 21.0% for 1 ACE (aPR = 1.3, 95% CI 1, 1.3), 29.0% for 2–3 ACEs (aPR = 1.6, 95% CI 1.4, 1.8), and 44.8% for ≥ 4 ACEs (aPR = 2.2, 95% CI 2.0, 2.5).

Conclusions

Our study provides novel evidence of the association of multiple ACEs with higher prevalence of poor HRQOL in cancer survivors.

Implications for cancer survivors

Screening for ACEs is warranted in all patients to guide targeted interventions to improve HRQOL and mitigate the impact of ACEs on HRQoL in cancer survivors.

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Title: Association between adverse childhood experiences and health related quality of life in adult cancer survivors in the United States
Authors: Emily C. Merkel
Daron M. Vandeleur
Xin Cheng
Alyson J. Littman
K. Scott Baker
Publication date: 03-05-2024
Publisher: Springer US
Published in: Journal of Cancer Survivorship
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-024-01603-5

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