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Reproductive Biology and Endocrinology

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Open Access 01-12-2010 | Methodology

Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population

Authors: Chunmei Liu, Jing Wang, Sirui Zhou, Binbin Wang, Xu Ma

Published in: Reproductive Biology and Endocrinology | Issue 1/2010

Abstract

Objectives

TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy.

Study Design

A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis.

Results

lack of association was found in TNF-alpha -308 SNP yet a significant difference was discovered in -238 polymorphism.

Conclusion

This study suggested that TNF-alpha may be a risk factor in Chinese RSA patients. However the ethnic differences may also contribute to the results.

Li TC, Makris M, Tomsu M, Tuckerman E, Laird S: Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update. 2002, 8 (5): 463-81. 10.1093/humupd/8.5.463.CrossRefPubMed

Wold AS, Arici A: Natural killer cells and reproductive failure. Curr Opin Obstet Gynecol. 2005, 17 (3): 237-41. 10.1097/01.gco.0000169099.98589.5b.CrossRefPubMed

Reid JG, Simpson NA, Walker RG, Economidou O, Shillito J, Gooi HC, Duffy SR, Walker JJ: The carriage of pro-inflammatory cytokine gene polymorphisms in recurrent pregnancy loss. Am J Reprod Immunol. 2001, 45 (1): 35-40. 10.1111/j.8755-8920.2001.450106.x.CrossRefPubMed

El-Far M, El-Sayed IH, El-Motwally AE, Hashem IA, Bakry N: Serum levels of TNF-alpha and antioxidant enzymes and placental TNF-alpha expression in unexplained recurrent spontaneous miscarriage. J Physiol Biochem. 2009, 65 (2): 175-81. 10.1007/BF03179068.CrossRefPubMed

Clark DA, Chaouat G, Arck PC, Mittruecker HW, Levy GA: Cytokine-dependent abortion in CBA × DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase]. J Immunol. 1998, 15 (160(2)): 545-9.

Huizinga TW, Westendorp RG, Bollen EL, Keijsers V, Brinkman BM, Langermans JA, Breedveld FC, Verweij CL, van de Gaer L, Dams L, Crusius JB, García-Gonzalez A, van Oosten BW, Polman CH, Peña AS: TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J Neuroimmunol. 1997, 72 (2): 149-53. 10.1016/S0165-5728(96)00182-8.CrossRefPubMed

QIAamp^® DNA Mini Kit and QIAamp DNA Blood Mini Kit Handbook.

Kwak-Kim J, Lee SK, Gilman-Sachs A: Elevated Th1/Th2 cell ratios in a pregnant woman with a history of RSA, secondary Sjögren's syndrome and rheumatoid arthritis complicated with one fetal demise of twin pregnancy. Am J Reprod Immunol. 2007, 58 (4): 325-9. 10.1111/j.1600-0897.2007.00506.x.CrossRefPubMed

Anderson GM, Nakada MT, DeWitte M: Tumor necrosis factor-alpha in the pathogenesis and treatment of cancer. Curr Opin Pharmacol. 2004, 4: 314-20. 10.1016/j.coph.2004.04.004.CrossRefPubMed

10.

Stein CM, Nshuti L, Chiunda AB, Boom WH, Elston RC, Mugerwa RD, Iyengar SK, Whalen CC: Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis. Hum Hered. 2005, 60: 109-118. 10.1159/000088913.CrossRefPubMed

11.

McCusker SM, Curran MD, Dynan KB, McCullagh CD, Urquhart DD, Middleton D, Patterson CC, McIlroy SP, Passmore AP: Association between polymorphism in regulatory region of gene encoding tumour necrosis factor-alpha and risk of Alzheimer's disease and vascular dementia: a case-control study. Lancet. 2001, 357: 436-439. 10.1016/S0140-6736(00)04008-3.CrossRefPubMed

12.

Winchester EC, Millwood IY, Rand L, Penny MA, Kessling AM: Association of the TNF-alpha-308 (G-A) polymorphism with self-reported history of childhood asthma. Hum Genet. 2000, 107: 591-596. 10.1007/s004390000410.CrossRefPubMed

13.

Costeas PA, Koumouli A, Giantsiou-Kyriakou A, Papaloizou A, Koumas L: Th2/Th3 cytokine genotypes are associated with pregnancy loss. Hum Immunol. 2004, 65: 135-141. 10.1016/j.humimm.2003.11.007.CrossRefPubMed

14.

Pietrowski D, Bettendorf H, Keck C, Bürkle B, Unfried G, Riener EK, Hefler LA, Tempfer C: Lack of association of TNFalpha gene polymorphisms and recurrent pregnancy loss in Caucasian women. J Reprod Immunol. 2004, 61 (1): 51-58. 10.1016/j.jri.2003.12.001.CrossRefPubMed

15.

Daher S, Shulzhenko N, Morgun A, Mattar R, Rampim GF, Camano L, DeLima MG: Associations between cytokine gene polymorphisms and recurrent pregnancy loss. J Reprod Immunol. 2003, 58 (1): 69-77. 10.1016/S0165-0378(02)00059-1.CrossRefPubMed

16.

Zammiti W, Mtiraoui N, Finan RR, Almawi WY, Mahjoub T: Tumor necrosis factor alpha and lymphotoxin alpha haplotypes in idiopathic recurrent pregnancy loss. Fertil Steril. 2009, 91 (5): 1903-8. 10.1016/j.fertnstert.2008.01.090.CrossRefPubMed

17.

Fong CL, Mark DF: The NF-kappa B-like site in the TNF-alpha repressor element is essential for its repressor function. Biochem Biophys Res Commun. 1995, 26 (212(3)): 879-86. 10.1006/bbrc.1995.2051.CrossRef

Title: Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population
Authors: Chunmei Liu
Jing Wang
Sirui Zhou
Binbin Wang
Xu Ma
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2010
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/1477-7827-8-114

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population

Abstract

Objectives

Study Design

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Study Design

Results

Conclusion

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