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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 3/2016

01-03-2016 | Gynecologic Oncology

Assessment of uterine enhancement rate after abdominal radical trachelectomy using dynamic contrast-enhanced magnetic resonance imaging

Authors: Hiroshi Makino, Hiroki Kato, Tatsuro Furui, Yoh Hayasaki, Ken-ichirou Morishige, Masayuki Kanematsu

Published in: Archives of Gynecology and Obstetrics | Issue 3/2016

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Abstract

Purpose

The purpose of this study was to assess uterine enhancement rate after abdominal radical trachelectomy (ART) using dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging.

Methods

Ten patients with early uterine cervical cancer, who were treated by ART, were included in this study. Each patient underwent DCE MR imaging using a 3 T unit to assess uterine enhancement rate at three times (before surgery and 1 and 3 months after surgery). The radiologist calculated mean signal intensities of the anterior and posterior myometrium and also measured the signal intensities of the urine in the bladder on the same image, which was expressed as the myometrium-to-urine signal intensity ratio. In the time–intensity ratio curve, enhancement parameters (peak signal intensity ratio and peak time) of the uterine body were compared across the three MR examinations.

Results

The peak signal intensity ratio was 6.96 ± 0.98 on MR examinations before surgery, 6.14 ± 0.81 1 month after surgery, and 6.26 ± 0.63 3 months after surgery (p = 0.069). The peak time was 57.6 ± 3.4 s on MR examinations before surgery, 56.4 ± 4.4 s 1 month after surgery, and 53.2 ± 8.0 s 3 months after surgery (p = 0.304). No significant differences were found in either the peak signal intensity ratio or peak time across the three MR examinations.

Conclusions

That no significant decrease of uterine enhancement rate was found after surgery suggests the uterine function and fertility may be preserved after ART.
Literature
1.
2.
Foley G, Alston R, Geraci M et al (2011) Increasing rates of cervical cancer in young women in England: an analysis of national data 1982–2006. Br J Cancer 105:177–184PubMedCentralCrossRefPubMed
3.
Takemoto S, Kamura T (2012) Natural history, epidemiology and statistics of gynecologic cancers. Nihon Rinsho 70(Suppl 4):5–9PubMed
4.
Uchida H, Kobayashi M, Hosobuchi A et al (2014) Age, period, and birth cohort-specific effects on cervical cancer mortality rates in Japanese women and projections for mortality rates over 20-year period (2012–2031). Nihon Eiseigaku Zasshi 69:215–224CrossRefPubMed
5.
Dargent D, Martin X, Sacchetoni A et al (2000) Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients. Cancer 88:1877–1882CrossRefPubMed
6.
Smith JR, Boyle DC, Corless DJ et al (1997) Abdominal radical trachelectomy: a new surgical technique for the conservative management of cervical carcinoma. Br J Obstet Gynaecol 104:1196–1200CrossRefPubMed
7.
Koh WJ, Greer BE, Abu-Rustum NR et al (2013) Cervical cancer. J Natl Compr Canc Netw 11:320–343PubMed
8.
Pareja R, Rendon GJ, Sanz-Lomana CM et al (2013) Surgical, oncological, and obstetrical outcomes after abdominal radical trachelectomy—a systematic literature review. Gynecol Oncol 131:77–82CrossRefPubMed
9.
Du XL, Sheng XG, Jiang T et al (2011) Sentinel lymph node biopsy as guidance for radical trachelectomy in young patients with early stage cervical cancer. BMC Cancer 11:157PubMedCentralCrossRefPubMed
10.
Kim JH, Park JY, Kim DY et al (2010) Fertility-sparing laparoscopic radical trachelectomy for young women with early stage cervical cancer. BJOG 117:340–347CrossRefPubMed
11.
Klemm P, Tozzi R, Kohler C et al (2005) Does radical trachelectomy influence uterine blood supply? Gynecol Oncol 96:283–286CrossRefPubMed
12.
Umemura K, Ishioka S, Endo T et al (2010) Changes of uterine blood flow after vaginal radical trachelectomy (VRT) in patients with early-stage uterine invasive cervical cancer. Int J Med Sci 7:260–266PubMedCentralCrossRefPubMed
13.
Tang J, Li J, Wang S et al (2014) On what scale does it benefit the patients if uterine arteries were preserved during ART? Gynecol Oncol 134:154–159CrossRefPubMed
14.
Nicolet V, Carignan L, Bourdon F et al (2000) MR imaging of cervical carcinoma: a practical staging approach. Radiographics 20:1539–1549CrossRefPubMed
15.
Tsuda K, Murakami T, Kurachi H et al (1997) MR imaging of cervical carcinoma: comparison among T2-weighted, dynamic, and postcontrast T1-weighted images with histopathological correlation. Abdom Imaging 22:103–107CrossRefPubMed
16.
Balleyguier C, Sala E, Da Cunha T et al (2011) Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology. Eur Radiol 21:1102–1110CrossRefPubMed
17.
Peppercorn PD, Jeyarajah AR, Woolas R et al (1999) Role of MR imaging in the selection of patients with early cervical carcinoma for fertility-preserving surgery: initial experience. Radiology 212:395–399CrossRefPubMed
18.
Lakhman Y, Akin O, Park KJ et al (2013) Stage IB1 cervical cancer: role of preoperative MR imaging in selection of patients for fertility-sparing radical trachelectomy. Radiology 269:149–158CrossRefPubMed
19.
Bourgioti C, Koutoulidis V, Chatoupis K et al (2014) MRI findings before and after abdominal radical trachelectomy (ART) for cervical cancer: a prospective study and review of the literature. Clin Radiol 69:678–686CrossRefPubMed
20.
Cha S, Knopp EA, Johnson G et al (2002) Intracranial mass lesions: dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging. Radiology 223:11–29CrossRefPubMed
21.
Detre JA, Alsop DC, Vives LR et al (1998) Noninvasive MRI evaluation of cerebral blood flow in cerebrovascular disease. Neurology 50:633–641CrossRefPubMed
22.
Kim CH, Abu-Rustum NR, Chi DS et al (2012) Reproductive outcomes of patients undergoing radical trachelectomy for early-stage cervical cancer. Gynecol Oncol 125:585–588CrossRefPubMed
23.
Speiser D, Mangler M, Kohler C et al (2011) Fertility outcome after radical vaginal trachelectomy: a prospective study of 212 patients. Int J Gynecol Cancer 21:1635–1639CrossRefPubMed
24.
Park JY, Kim DY, Suh DS et al (2014) Reproductive outcomes after laparoscopic radical trachelectomy for early-stage cervical cancer. J Gynecol Oncol 25:9–13PubMedCentralCrossRefPubMed
25.
Dursun P, LeBlanc E, Nogueira MC (2007) Radical vaginal trachelectomy (Dargent’s operation): a critical review of the literature. Eur J Surg Oncol 33:933–941CrossRefPubMed
26.
Choi SY, Lee KH, Suk HJ et al (2014) Successful pregnancy by direct intraperitoneal insemination in an infertile patient with failure of recanalization of isthmic stenosis after laparoscopic radical trachelectomy. Obstet Gynecol Sci 57:82–85PubMedCentralCrossRefPubMed
Metadata
Title
Assessment of uterine enhancement rate after abdominal radical trachelectomy using dynamic contrast-enhanced magnetic resonance imaging
Authors
Hiroshi Makino
Hiroki Kato
Tatsuro Furui
Yoh Hayasaki
Ken-ichirou Morishige
Masayuki Kanematsu
Publication date
01-03-2016
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 3/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-015-3842-7

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