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01-07-2017 | Chest

Assessment of regional emphysema, air-trapping and Xenon-ventilation using dual-energy computed tomography in chronic obstructive pulmonary disease patients

Authors: Sang Min Lee, Joon Beom Seo, Hye Jeon Hwang, Namkug Kim, Sang Young Oh, Jae Seung Lee, Sei Won Lee, Yeon-Mok Oh, Tae Hoon Kim

Published in: European Radiology | Issue 7/2017

Abstract

Objectives

To compare the parenchymal attenuation change between inspiration/expiration CTs with dynamic ventilation change between xenon wash-in (WI) inspiration and wash-out (WO) expiration CTs.

Methods

52 prospectively enrolled COPD patients underwent xenon ventilation dual-energy CT during WI and WO periods and pulmonary function tests (PFTs). The parenchymal attenuation parameters (emphysema index (EI), gas-trapping index (GTI) and air-trapping index (ATI)) and xenon ventilation parameters (xenon in WI (Xe-WI), xenon in WO (Xe-WO) and xenon dynamic (Xe-Dyna)) of whole lung and three divided areas (emphysema, hyperinflation and normal) were calculated on virtual non-contrast images and ventilation images. Pearson correlation, linear regression analysis and one-way ANOVA were performed.

Results

EI, GTI and ATI showed a significant correlation with Xe-WI, Xe-WO and Xe-Dyna (EI R = −.744, −.562, −.737; GTI R = −.621, −.442, −.629; ATI R = −.600, −.421, −.610, respectively, p < 0.01). All CT parameters showed significant correlation with PFTs except forced vital capacity (FVC). There was a significant difference in GTI, ATI and Xe-Dyna in each lung area (p < 0.01).

Conclusions

The parenchymal attenuation change between inspiration/expiration CTs and xenon dynamic change between xenon WI- and WO-CTs correlate significantly. There are alterations in the dynamics of xenon ventilation between areas of emphysema.

Key Points

• The xenon ventilation change correlates with the parenchymal attenuation change.

• The xenon ventilation change shows the difference between three lung areas.

• The combination of attenuation and xenon can predict more accurate PFTs.

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Title: Assessment of regional emphysema, air-trapping and Xenon-ventilation using dual-energy computed tomography in chronic obstructive pulmonary disease patients
Authors: Sang Min Lee
Joon Beom Seo
Hye Jeon Hwang
Namkug Kim
Sang Young Oh
Jae Seung Lee
Sei Won Lee
Yeon-Mok Oh
Tae Hoon Kim
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 7/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4657-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Assessment of regional emphysema, air-trapping and Xenon-ventilation using dual-energy computed tomography in chronic obstructive pulmonary disease patients

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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