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01-06-2014 | Gynecologic Endocrinology and Reproductive Medicine

Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study

Authors: Özgür Bilgin Yiyenoğlu, Mete Gürol Uğur, Hüseyin Çağlayan Özcan, Günay Can, Ebru Öztürk, Özcan Balat, Özcan Erel

Published in: Archives of Gynecology and Obstetrics | Issue 6/2014

Abstract

Objective

To determine the levels of oxidative stress markers in recurrent pregnancy loss using a novel automated method.

Materials and methods

30 pregnant women in their first trimester with a history of recurrent pregnancy loss (RPL) and 30 healthy pregnant women were enrolled in this prospective controlled study. Total antioxidant capacity (TAC), total oxidant level (TOL) and oxidative stress index (OSI) in maternal serum were measured using the more recently designated Erel method.

Results

We observed statistically significant increased TOL and OSI levels in patient group (p = 0.032, p = 0.007, respectively). We also demonstrated statistically significant decreased TAC in pregnant women who had a history of RPL (p = 0.013).

Conclusion

Our results support the concept that oxidative stress plays a central role in the etiopathogenesis of RPL. Further studies to evaluate the predictive role of TAC, TOL, OSI levels using Erel method are needed.

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Title: Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study
Authors: Özgür Bilgin Yiyenoğlu
Mete Gürol Uğur
Hüseyin Çağlayan Özcan
Günay Can
Ebru Öztürk
Özcan Balat
Özcan Erel
Publication date: 01-06-2014
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 6/2014
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-3113-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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