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Published in: European Journal of Nuclear Medicine and Molecular Imaging 2/2016

01-02-2016 | Original Article

Assessment of endothelial function and myocardial flow reserve using 15O-water PET without attenuation correction

Authors: Stéphane Tuffier, Damien Legallois, Annette Belin, Michael Joubert, Alban Bailliez, Michel Redonnet, Denis Agostini, Alain Manrique

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2016

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Abstract

Purpose

Myocardial blood flow (MBF) measurement using positron emission tomography (PET) from the washout rate of 15O-water is theoretically independent of tissue attenuation. The aim of this study was to evaluate the impact of not using attenuation correction in the assessment of coronary endothelial function and myocardial flow reserve (MFR) using 15O-water PET.

Methods

We retrospectively processed 70 consecutive 15O-water PET examinations obtained at rest and during cold pressor testing (CPT) in patients with dilated cardiomyopathy (n = 58), or at rest and during adenosine infusion in heart transplant recipients (n = 12). Data were reconstructed with attenuation correction (AC) and without attenuation correction (NAC) using filtered backprojection, and MBF was quantified using a single compartmental model. The agreement between AC and NAC data was assessed using Lin’s concordance correlation coefficient followed by Bland-Altman plot analysis.

Results

Regarding endothelial function, NAC PET showed poor reproducibility and poor agreement with AC PET data. Conversely, NAC PET demonstrated high reproducibility and a strong agreement with AC PET for the assessment of MFR.

Conclusion

Non-attenuation-corrected 15O-water PET provided an accurate measurement of MFR compared to attenuation-corrected PET. However, non-attenuation-corrected PET data were less effective for the assessment of endothelial function using CPT in this population.
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Metadata
Title
Assessment of endothelial function and myocardial flow reserve using 15O-water PET without attenuation correction
Authors
Stéphane Tuffier
Damien Legallois
Annette Belin
Michael Joubert
Alban Bailliez
Michel Redonnet
Denis Agostini
Alain Manrique
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-015-3163-x

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