Skip to main content
Top
Published in: Supportive Care in Cancer 7/2007

01-07-2007 | Original Article

Assessment of clinical relevant fatigue level in cancer

Authors: Yoon Jung Chang, Jung Suk Lee, Chang Geol Lee, Won Sup Lee, Keun Seok Lee, Soo-Mee Bang, Xin Shelley Wang, Tito R. Mendoza, Charles S. Cleeland, Young Ho Yun

Published in: Supportive Care in Cancer | Issue 7/2007

Login to get access

Abstract

Goals of work

Fatigue is highly prevalent in cancer and greatly inferences with daily life. The goal of this study was to identify the most informative score in the Brief Fatigue Inventory and to define cut points for “mild,” “moderate,” and “severe” fatigue based on their relevance to quality of life (QOL).

Patients and methods

We surveyed cancer patients at five hospitals in Korea with self-administrated questionnaires. The patients were older than 18 years, have a histological diagnosis of malignancy, gave informed consent to participate, and were able to understand the questionnaires. We analyzed 150 cancer patients who reported fatigue.

Main result

“Usual fatigue” was a sensitive and reliable indicator of fatigue severity and was defined as mild (1–3), moderate (4–7), or severe (8–10) because it had the strongest correlation with the functional interference, symptoms, depression, and QOL.

Conclusion

These cutpoints might be useful in clinical evaluation of fatigue in cancer. Our findings suggest a simple technique for the rapid screening of fatigue and for evaluating its impact on the symptoms and daily functioning of cancer patients.
Literature
1.
go back to reference Diane I, Leslie V, Jahe EG et al (1994) The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy. Cancer Nurs 17:367–378 Diane I, Leslie V, Jahe EG et al (1994) The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy. Cancer Nurs 17:367–378
2.
go back to reference Respini D, Jacobsen PB, Thors C, Tralongo P, Balducci L (2003) The prevalence and correlates of fatigue in older cancer patients. Crit Rev Oncol/Hematol 47:273–279CrossRef Respini D, Jacobsen PB, Thors C, Tralongo P, Balducci L (2003) The prevalence and correlates of fatigue in older cancer patients. Crit Rev Oncol/Hematol 47:273–279CrossRef
3.
go back to reference Stone P, Richardson A, Ream E, Smith AG, Kerr DJ, Kearney N (2000) Cancer-related fatigue: inevitable, unimportant and untreatable? Results of a multi-centre patient survey. Cancer fatigue forum. Ann Oncol 11:971–975PubMedCrossRef Stone P, Richardson A, Ream E, Smith AG, Kerr DJ, Kearney N (2000) Cancer-related fatigue: inevitable, unimportant and untreatable? Results of a multi-centre patient survey. Cancer fatigue forum. Ann Oncol 11:971–975PubMedCrossRef
4.
go back to reference Richardson A (1995) Fatigue in cancer patients: a review of the literature. Eur J Cancer Care 4:20–32 Richardson A (1995) Fatigue in cancer patients: a review of the literature. Eur J Cancer Care 4:20–32
5.
go back to reference Vogelzang N, Breitbart W, Cella D et al (1997) Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tri-part assessment survey. Semin Hematol 34:4–12PubMed Vogelzang N, Breitbart W, Cella D et al (1997) Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tri-part assessment survey. Semin Hematol 34:4–12PubMed
6.
go back to reference Vainio A, Auvinen A (1996) Prevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom prevalence group. J Pain Symptom Manage 12:3–10PubMedCrossRef Vainio A, Auvinen A (1996) Prevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom prevalence group. J Pain Symptom Manage 12:3–10PubMedCrossRef
7.
go back to reference Blesch KS, Paice JA, Wickham R et al (1991) Correlates of fatigue in people with breast or lung cancer. Oncol Nurs Forum 18:81–87PubMed Blesch KS, Paice JA, Wickham R et al (1991) Correlates of fatigue in people with breast or lung cancer. Oncol Nurs Forum 18:81–87PubMed
8.
go back to reference Okuyama T, Wang XS, Akechi T, Mendoza TR, Hosaka T, Cleeland CS, Uchitomi Y (2003) Validation study of the Japanese version of the Brief Fatigue Inventory. J Pain Symptom Manage 25:106–117PubMedCrossRef Okuyama T, Wang XS, Akechi T, Mendoza TR, Hosaka T, Cleeland CS, Uchitomi Y (2003) Validation study of the Japanese version of the Brief Fatigue Inventory. J Pain Symptom Manage 25:106–117PubMedCrossRef
9.
go back to reference Hwang SS, Chang VT, Cogswell J, Kasimis BS (2002) Clinical relevance of fatigue levels in cancer patients at a veterans administration medical center. Cancer 94:2481–2489PubMedCrossRef Hwang SS, Chang VT, Cogswell J, Kasimis BS (2002) Clinical relevance of fatigue levels in cancer patients at a veterans administration medical center. Cancer 94:2481–2489PubMedCrossRef
10.
go back to reference Irvine D, Vincent L, Graydon JE et al (1994) The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy: A comparison with the fatigue experienced by healthy individuals. Cancer Nurs 17:367–378PubMedCrossRef Irvine D, Vincent L, Graydon JE et al (1994) The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy: A comparison with the fatigue experienced by healthy individuals. Cancer Nurs 17:367–378PubMedCrossRef
11.
go back to reference Serlin RC, Mendoza TR, Nakamura Y, Edwards KR, Cleeland CS (1995) When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain 61:277–287PubMedCrossRef Serlin RC, Mendoza TR, Nakamura Y, Edwards KR, Cleeland CS (1995) When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain 61:277–287PubMedCrossRef
12.
go back to reference Yun YH, Wang XS, Lee JS et al (2005) Validation study of the Korean version of the Brief Fatigue Inventory. J Pain Symptom Manage 29:165–172PubMedCrossRef Yun YH, Wang XS, Lee JS et al (2005) Validation study of the Korean version of the Brief Fatigue Inventory. J Pain Symptom Manage 29:165–172PubMedCrossRef
13.
go back to reference Wang XS, Hao XS, Wang Y et al (2004) Validation study of the Chinese version of the Brief Fatigue Inventory (BFI-C). J Pain Symptom Manage 27:322–332PubMedCrossRef Wang XS, Hao XS, Wang Y et al (2004) Validation study of the Chinese version of the Brief Fatigue Inventory (BFI-C). J Pain Symptom Manage 27:322–332PubMedCrossRef
14.
go back to reference Morrow GR, Andrews PLR, Hickok JT, Roscoe JA, Matteson S (2002) Fatigue associated with cancer and its treatment. Support Care Cancer 10:389–398PubMedCrossRef Morrow GR, Andrews PLR, Hickok JT, Roscoe JA, Matteson S (2002) Fatigue associated with cancer and its treatment. Support Care Cancer 10:389–398PubMedCrossRef
15.
go back to reference Lesage P, Portenoy R (2002) Management of fatigue in the cancer patient. Oncology 16:373–389PubMed Lesage P, Portenoy R (2002) Management of fatigue in the cancer patient. Oncology 16:373–389PubMed
16.
go back to reference DeVita VT, Hellman S, Rosenberg SA (eds) (2005) Clinical oncology, 3rd edn. Williams & Wilkins, Philadelphia DeVita VT, Hellman S, Rosenberg SA (eds) (2005) Clinical oncology, 3rd edn. Williams & Wilkins, Philadelphia
17.
go back to reference Mendoza TR, Wang XS, Cleeland CS et al (1999) The rapid assessment of fatigue severity in cancer patients. Cancer 85:1186–1196PubMedCrossRef Mendoza TR, Wang XS, Cleeland CS et al (1999) The rapid assessment of fatigue severity in cancer patients. Cancer 85:1186–1196PubMedCrossRef
18.
go back to reference Aaronson NK, Ahmedzai S, Dergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376PubMedCrossRef Aaronson NK, Ahmedzai S, Dergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376PubMedCrossRef
19.
go back to reference Yun YH, Park YS, Lee ES et al (2004) Validation of the Korean version of the EORTC QLQ-C30. Qual Life Res 13:863–868PubMedCrossRef Yun YH, Park YS, Lee ES et al (2004) Validation of the Korean version of the EORTC QLQ-C30. Qual Life Res 13:863–868PubMedCrossRef
20.
go back to reference Bech P (1981) Rating scales for affective disorders: Their validity and consistency. Acta Psychiatr Scand Suppl 295:1–101PubMed Bech P (1981) Rating scales for affective disorders: Their validity and consistency. Acta Psychiatr Scand Suppl 295:1–101PubMed
21.
go back to reference Hahn HM, Yum TH, Shin YH et al (1986) A standardization study of Beck Depression Inventory in Korea. Journal of Korean Neuropsychiatric Association 25:487–502 Hahn HM, Yum TH, Shin YH et al (1986) A standardization study of Beck Depression Inventory in Korea. Journal of Korean Neuropsychiatric Association 25:487–502
22.
go back to reference Cleeland CS, Mendoza TR, Wang XS et al (2000) Assessing symptom distress in cancer: The M.D. Anderson Symptom Inventory. Cancer 89:1634–1646PubMedCrossRef Cleeland CS, Mendoza TR, Wang XS et al (2000) Assessing symptom distress in cancer: The M.D. Anderson Symptom Inventory. Cancer 89:1634–1646PubMedCrossRef
23.
go back to reference Yun YH, Mendoza TR, Kang IO et al (2006) Validation study of the Korean version of the M. D. Anderson Symptom Inventory. J Pain Symptom Manage 31(4):345–352PubMedCrossRef Yun YH, Mendoza TR, Kang IO et al (2006) Validation study of the Korean version of the M. D. Anderson Symptom Inventory. J Pain Symptom Manage 31(4):345–352PubMedCrossRef
Metadata
Title
Assessment of clinical relevant fatigue level in cancer
Authors
Yoon Jung Chang
Jung Suk Lee
Chang Geol Lee
Won Sup Lee
Keun Seok Lee
Soo-Mee Bang
Xin Shelley Wang
Tito R. Mendoza
Charles S. Cleeland
Young Ho Yun
Publication date
01-07-2007
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 7/2007
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-007-0219-x

Other articles of this Issue 7/2007

Supportive Care in Cancer 7/2007 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine