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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2007

01-04-2007

Assessment of Clinical Outcome in Patients With Esophageal Squamous Cell Carcinoma Using TNM Classification Score and Molecular Biological Classification

Authors: Shinsuke Takeno, MD, PhD, Tsuyoshi Noguchi, MD, PhD, Yoshiaki Takahashi, MD, PhD, Shoichi Fumoto, MD, Tomotaka Shibata, MD, Katsunobu Kawahara, MD, PhD

Published in: Annals of Surgical Oncology | Issue 4/2007

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Abstract

Background

The aim of this study was to assess the clinical outcome in patients with esophageal squamous cell carcinoma (ESCC) by using molecular biological classification based on immunohistochemical analysis in addition to tumor, node, metastasis system (TNM) classification.

Methods

Samples from 71 patients with ESCC who underwent surgery were analyzed immunohistochemically. Cyclin B1, E-cadherin, Bag-1, and heat-shock protein 70 were selected as the molecular biological parameters. The utility of molecular biological classification on clinical impact was examined and compared with TNM classification.

Results

Three patients were diagnosed as stage 0, 14 as stage I, 20 as stage II, 19 as stage III, and 15 as stage IV by TNM classification. Thirteen patients were classified as stage 0, 17 as stage I, 21 as stage II, 18 as stage III, and 2 as stage IV by molecular biological classification. Molecular biological stage (P < .0001) and TNM stage (P < .0001) were statistically significant prognostic parameters in univariate analysis. Twenty (28.2%) of 71 patients were assigned to the same stage by both classifications, and a significant correlation was identified between the two classifications (P = .0002). Molecular biological classification (P < .01) and TNM classification (P < .0001) were independent prognostic parameters in multivariate analysis. Combined TNM and molecular biological classification accurately reflected clinical outcome (P < .0001).

Conclusions

Molecular biological classification combined with TNM classification is useful for assessing the prognosis of patients with ESCC.
Literature
1.
Pisani P, Parkin DM, Bray F, Ferlay J. Estimates of the world-wide mortality from 25 cancers in 1990. Int J Cancer 1999; 83:18–29PubMedCrossRef
2.
3.
Sobin LH, Wittekind CH. (1997) International Union Against Cancer (UICC). TNM Classification of Malignant Tumours. 5th ed. New York: Wiley, pp 54–8
4.
Takeno S, Noguchi T, Kikuchi R, Uchida Y, Yokoyama S, Mueller W. Prognostic value of cyclin B1 in patients with esophageal squamous cell carcinoma. Cancer 2002; 94:2874–81PubMedCrossRef
5.
Noguchi T, Takeno S, Shibata T, et al. Nuclear BAG-1 expression is a biomarker of poor prognosis in esophageal squamous cell carcinoma. Dis Esophagus 2003; 16:107–11PubMedCrossRef
6.
Takeno S, Noguchi T, Fumoto S, Kimura Y, Shibata T, Kawahara K. E-cadherin expression in patients with esophageal squamous cell carcinoma: promoter hypermethylation, snail overexpression, clinicopathological implications. Am J Clin Pathol 2004; 122:78–84PubMedCrossRef
7.
Noguchi T, Takeno S, Shibata T, Uchida Y, Yokoyama S, Mueller W. Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma. Ann Thorac Surg 2002; 74:222–6PubMedCrossRef
8.
Noguchi T, Takeno S, Shibata T, Uchida Y, Yokoyama S, Muller W. VEGF-C expression correlates with histological differentiation and metastasis in squamous cell carcinoma of the esophagus. Oncol Rep 2002; 9:995–9PubMed
9.
Noguchi T, Takeno S, Kimura Y, et al. FHIT expression and hypermethylation in esophageal squamous cell carcinoma. Int J Mol Med 2003; 11:441–7PubMed
10.
Shibata T, Noguchi T, Takeno S, Takahashi Y, Fumoto S, Kawahara K. Impact of nuclear galectin-3 expression on histological differentiation and vascular invasion in patients with esophageal squamous cell carcinoma. Oncol Rep 2005; 13:235–9PubMed
11.
Shiozaki H, Doki Y, Kawanishi K, et al. Clinical application of malignancy potential grading as a prognostic factor of human esophageal cancers. Surgery 2000; 127:552–61PubMedCrossRef
12.
Shimada Y, Imamura M, Watanabe G, et al. Prognostic factors of oesophageal squamous cell carcinoma from the perspective of molecular biology. Br J Cancer 1999; 80:1281–8PubMedCrossRef
13.
Inada S, Koto T, Futami K, Arima S, Iwashita A. Evaluation of malignancy and the prognosis of esophageal cancer based on an immunohistochemical study (p53, E-cadherin, epidermal growth factor receptor). Surg Today 1999; 29:493–503PubMedCrossRef
14.
Nozoe T, Korenaga D, Kabashima A, Ohga T, Saeki H, Sugimachi K. Significance of cyclin B1 expression as an independent prognostic indicator of patients with squamous cell carcinoma of the esophagus. Clin Cancer Res 2002; 8:817–22PubMed
15.
Murakami H, Furihata M, Ohtsuki Y, Ogoshi S. Determination of the prognostic significance of cyclin B1 overexpression in patients with esophageal squamous cell carcinoma. Virchows Arch 1999; 434:153–8PubMedCrossRef
16.
Tamura S, Shiozaki H, Miyata M, et al. Decreased E-cadherin expression is associated with haematogenous recurrence and poor prognosis in patients with squamous cell carcinoma of the oesophagus. Br J Surg 1996; 83:1608–14PubMedCrossRef
17.
Kawanishi K, Shiozaki H, Doki Y, et al. Prognostic significance of heat shock proteins 27 and 70 in patients with squamous cell carcinoma of the esophagus. Cancer 1999;85:1649–57PubMedCrossRef
18.
Lu J, Liu Z, Xiong M, et al. Gene expression profile changes in initiation and progression of squamous cell carcinoma of esophagus. Int J Cancer 2001; 91:288–94PubMedCrossRef
19.
Kihara C, Tsunoda T, Tanaka T, et al. Prediction of sensitivity of esophageal tumors to adjuvant chemotherapy by cDNA microarray analysis of gene-expression profiles. Cancer Res 2001; 61:6474–9PubMed
20.
Kan T, Shimada Y, Sato F, et al. Prediction of lymph node metastasis with use of artificial neural networks based on gene expression profiles in esophageal squamous cell carcinoma. Ann Surg Oncol 2004; 11:1070–8PubMedCrossRef
21.
Callagy G, Pharoah P, Chin SF, Sangan T, Daigo Y, Jackson L, Caldas C. Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays. J Pathol 2005; 205:388–96PubMedCrossRef
22.
Makretsov NA, Huntsman DG, Nielsen TO, et al. Hierarchical clustering analysis of tissue microarray immunostaining data identifies prognostically significant groups of breast carcinoma. Clin Cancer Res 2004; 10:6143–51PubMedCrossRef
23.
Prall F, Ostwald C, Nizze H, Barten M. Expression profiling of colorectal carcinomas using tissue microarrays: cell cycle regulatory proteins p21, p27, and p53 as immunohistochemical prognostic markers in univariate and multivariate analysis. Appl Immunohistochem Mol Morphol 2004; 12:111–21PubMed
24.
Au NH, Cheang M, Huntsman DG, et al. Evaluation of immunohistochemical markers in non–small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers. J Pathol 2004; 204:101–9PubMedCrossRef
25.
Fernebro E, Bendahl PO, Dictor M, Persson A, Ferno M, Nilbert M. Immunohistochemical patterns in rectal cancer: application of tissue microarray with prognostic correlations. Int J Cancer 2004; 111:921–8PubMedCrossRef
26.
Resnick MB, Routhier J, Konkin T, Sabo E, Pricolo VE. Epidermal growth factor receptor, c-MET, beta-catenin, and p53 expression as prognostic indicators in stage II colon cancer: a tissue microarray study. Clin Cancer Res 2004; 10:3069–75PubMedCrossRef
Metadata
Title
Assessment of Clinical Outcome in Patients With Esophageal Squamous Cell Carcinoma Using TNM Classification Score and Molecular Biological Classification
Authors
Shinsuke Takeno, MD, PhD
Tsuyoshi Noguchi, MD, PhD
Yoshiaki Takahashi, MD, PhD
Shoichi Fumoto, MD
Tomotaka Shibata, MD
Katsunobu Kawahara, MD, PhD
Publication date
01-04-2007
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 4/2007
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-006-9286-3

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