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Acta Neurologica Belgica
Published in: Acta Neurologica Belgica 1/2016

01-03-2016 | Letter to the Editor

Assessing the clinical features of LGI1 antibody encephalitis

Authors: Pan-Pan Zhao, Ying Zhang, Lan Gao, Li Sun

Published in: Acta Neurologica Belgica | Issue 1/2016

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Excerpt

Limbic encephalitis (LE) is a rare neurologic condition that is characterized by subacute onset of memory dysfunction, abnormal behavior, seizures, psychiatric symptoms, and decreased level of consciousness. Leucine-rich, glioma inactivated 1 (LGI1) antibody encephalitis is characterized by faciobrachial dystonic seizures (FBDS), hyponatremia, and a florid amnestic syndrome, and it is not convincingly associated with cancer [1]. Early and correct diagnosis, coupled with early-initiated immunotherapy may improve the prognosis. Here, we report three Chinese patients with LGI1-positive antibodies in the cerebral spinal fluid (CSF) or serum, and analyze the clinical characteristics, therapeutic strategies, and outcomes of the patients. …
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Irani SR, Pettingill P, Kleopa KA, Schiza N, Waters P, Mazia C, Zuliani L, Watanabe O, Lang B, Buckley C, Vincent A (2012) Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol 72(2):241–255CrossRefPubMed
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Irani SR, Buckley C, Vincent A, Cockerell OC, Rudge P, Johnson MR, Smith S (2008) Immunotherapy-responsive seizure-like episodes with potassium channel antibodies. Neurology 71(20):1647–1648CrossRefPubMed
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Lai M, Huijbers MG, Lancaster E, Graus F, Bataller L, Balice-Gordon R, Cowell JK, Dalmau J (2010) Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol 9(8):776–785PubMedCentralCrossRefPubMed
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Geschwind MD, Tan KM, Lennon VA, Barajas RF Jr, Haman A, Klein CJ, Josephson SA, Pittock SJ (2008) Voltage-gated potassium channel autoimmunity mimicking Creutzfeldt–jakob disease. Arch Neurol 65(10):1341–1346PubMedCentralCrossRefPubMed
Metadata
Title
Assessing the clinical features of LGI1 antibody encephalitis
Authors
Pan-Pan Zhao
Ying Zhang
Lan Gao
Li Sun
Publication date
01-03-2016
Publisher
Springer Milan
Published in
Acta Neurologica Belgica / Issue 1/2016
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-015-0517-x

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