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Endocrine
Published in: Endocrine 2/2009

01-04-2009 | Original Paper

Aspirin prevents diabetic oxidative changes in rat lacrimal gland structure and function

Authors: Angélica Gobbi Jorge, Carolina Maria Módulo, Ana Carolina Dias, Alexandre Martins Braz, Rubens Bertazolli Filho, Alceu A. Jordão Jr, Jayter Silva de Paula, Eduardo Melani Rocha

Published in: Endocrine | Issue 2/2009

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Abstract

The aim of this study is to evaluate whether aspirin reduces Diabetis Mellitus (DM) oxidative damage in the lacrimal gland (LG), and ocular surface (OS). Ten weeks after streptozotocin induced DM and aspirin treatment, LG and OS of rats were compared for tear secretion, hidtology, peroxidase activity, and expression of uncoupling proteins (UCPs). DM reduction of tear secretion was prevented by aspirin (P < 0.01). Alterations of LG morphology and increased numbers of lipofucsin-like inclusions were observed in diabetic but not in aspirin-treated diabetic rats. Peroxidase activity levels were higher and UCP-2 was reduced in DM LG but not in aspirin treated (P = 0.0025 and P < 0.05, respectively). The findings prevented by aspirin indicate a direct inhibitory effect on oxidative pathways in LG and their inflammatory consequences, preserving the LG structure and function against hyperglycemia and/or insulin deficiency damage.
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Metadata
Title
Aspirin prevents diabetic oxidative changes in rat lacrimal gland structure and function
Authors
Angélica Gobbi Jorge
Carolina Maria Módulo
Ana Carolina Dias
Alexandre Martins Braz
Rubens Bertazolli Filho
Alceu A. Jordão Jr
Jayter Silva de Paula
Eduardo Melani Rocha
Publication date
01-04-2009
Publisher
Springer US
Published in
Endocrine / Issue 2/2009
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-009-9151-9

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