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Open Access 01-12-2013 | Opinion

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

Authors: Michael Berk, Olivia Dean, Hemmo Drexhage, John J McNeil, Steven Moylan, Adrienne O'Neil, Christopher G Davey, Livia Sanna, Michael Maes

Published in: BMC Medicine | Issue 1/2013

Abstract

There is compelling evidence to support an aetiological role for inflammation, oxidative and nitrosative stress (O&NS), and mitochondrial dysfunction in the pathophysiology of major neuropsychiatric disorders, including depression, schizophrenia, bipolar disorder, and Alzheimer's disease (AD). These may represent new pathways for therapy. Aspirin is a non-steroidal anti-inflammatory drug that is an irreversible inhibitor of both cyclooxygenase (COX)-1 and COX-2, It stimulates endogenous production of anti-inflammatory regulatory 'braking signals', including lipoxins, which dampen the inflammatory response and reduce levels of inflammatory biomarkers, including C-reactive protein, tumor necrosis factor-α and interleukin (IL)--6, but not negative immunoregulatory cytokines, such as IL-4 and IL-10. Aspirin can reduce oxidative stress and protect against oxidative damage. Early evidence suggests there are beneficial effects of aspirin in preclinical and clinical studies in mood disorders and schizophrenia, and epidemiological data suggests that high-dose aspirin is associated with a reduced risk of AD. Aspirin, one of the oldest agents in medicine, is a potential new therapy for a range of neuropsychiatric disorders, and may provide proof-of-principle support for the role of inflammation and O&NS in the pathophysiology of this diverse group of disorders.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/11/74/prepub

Title: Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness
Authors: Michael Berk
Olivia Dean
Hemmo Drexhage
John J McNeil
Steven Moylan
Adrienne O'Neil
Christopher G Davey
Livia Sanna
Michael Maes
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2013
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/1741-7015-11-74

At a glance: The STEP trials

Springer Medicine

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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