Published in:
01-12-2018 | ASO Author Reflections
ASO Author Reflections: Survival Benefit of Adjuvant Chemoradiotherapy for Gallbladder Cancer: The Role of Radiation Therapy Revisited
Authors:
Byoung Hyuck Kim, MD, Eui Kyu Chie, MD, PhD, Kyubo Kim, MD, PhD
Published in:
Annals of Surgical Oncology
|
Special Issue 3/2018
Login to get access
Excerpt
Gallbladder cancer (GBC) is a rare but highly aggressive malignancy even after radical resection. Locoregional recurrence is a significant cause of mortality in GBC, but the role of adjuvant radiotherapy (ART) is still debated and tends to be underestimated.
1 The impact of adjuvant chemotherapy still remains controversial. Recently, several retrospective studies based on a large database (The Surveillance, Epidemiology, and End Results or National Cancer Database) showed the survival benefit of adjuvant radio(chemo)therapy and supported the need to integrate ART into treatment strategies. Unfortunately, a well-designed prospective randomized trial to provide solid evidence would not be available in near future. Practice guidelines, including the National Comprehensive Cancer Network (NCCN) guideline, do not provide a clear answer to adjuvant treatment decision making. Therefore, to overcome past limitations of individual studies, a systematic review and meta-analysis was performed to explore the survival benefit of ART in GBC.
2 …
