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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2020

01-12-2020 | ASO Author Reflections

ASO Author Reflections: Patient-Derived Tumor Organoids—A Platform for a Precision Approach for Peritoneal Malignancies

Authors: Steven D. Forsythe, MS, Omeed Moaven, MD, Konstantinos I. Votanopoulos, MD, PhD, FACS

Published in: Annals of Surgical Oncology | Issue 13/2020

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Excerpt

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for appendiceal and colorectal malignancies have been practiced over the last 30 years based on pharmacokinetic data that, by definition, cannot capture individual patient response.1 Prospective randomized clinical trials that currently represent the gold standard in medical research have two major disadvantages: close to impossible accrual in rare diseases and the inability to predict the response of individual patients. …
Literature
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Levine EA, Stewart JHT, Shen P, Russell GB, Loggie BL, Votanopoulos KI. Intraperitoneal chemotherapy for peritoneal surface malignancy: experience with 1,000 patients. J Am Coll Surg. 2014;218(4):573–85.CrossRef
2.
Votanopoulos KI, Mazzocchi A, Sivakumar H, et al. Appendiceal cancer patient-specific tumor organoid model for predicting chemotherapy efficacy prior to initiation of treatment: a feasibility study. Ann Surg Oncol. 2019;26(1):139–47.CrossRef
3.
Votanopoulos KI, Forsythe S, Sivakumar H, et al. Model of patient-specific immune-enhanced organoids for immunotherapy screening: feasibility study. Ann Surg Oncol. 2019;27:1956–67.CrossRef
4.
Vlachogiannis G, Hedayat S, Vatsiou A, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science. 2018;359(6378):920–6.CrossRef
5.
Metadata
Title
ASO Author Reflections: Patient-Derived Tumor Organoids—A Platform for a Precision Approach for Peritoneal Malignancies
Authors
Steven D. Forsythe, MS
Omeed Moaven, MD
Konstantinos I. Votanopoulos, MD, PhD, FACS
Publication date
01-12-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-08909-5

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