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01-12-2020 | ASO Author Reflections

ASO Author Reflections: Not All Low-Grade Appendiceal Mucinous Neoplasm Mucin is Created Equal

Authors: Andrei Nikiforchin, MD, Vadim Gushchin, MD, FACS, Mary Caitlin King, BS, Armando Sardi, MD, FACS

Published in: Annals of Surgical Oncology | Issue 13/2020

Excerpt

Taken as a whole, patients with peritoneal dissemination of low-grade appendiceal mucinous neoplasms (LAMNs) treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) have a favorable prognosis.1^,2 However, some of these patients recur even after complete cytoreduction, and mucin composition and distribution may explain the difference in prognosis. Patients with peritoneal carcinomatosis of LAMN can have two types of peritoneal deposits containing acellular mucin (AM) or cellular mucin (CM) when epithelial cells are present.2 Although the American Joint Committee on Cancer 8th edition classifies both types of LAMN peritoneal spread as one prognostic group (stage IVa), there is some data that peritoneal lesions with AM and CM might affect survival differently.2^,3 Due to the rarity of the disease, this data is based on studies in mixed populations, including recurrent patients.3^,4 The impact of mucin cellularity on progression-free survival (PFS) and overall survival (OS) in newly diagnosed LAMN patients has not been reported. …

Jimenez W, Sardi A, Nieroda C, et al. Predictive and prognostic survival factors in peritoneal carcinomatosis from appendiceal cancer after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2014;21(13):4218–4225.CrossRef

Amin MB, Edge SB. AJCC cancer staging manual. Berlin: Springer; 2017.CrossRef

Choudry HA, Pai RK, Shuai Y, et al. Impact of cellularity on oncologic outcomes following cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for pseudomyxoma peritonei. Ann Surg Oncol. 2018;25(1):76–82.CrossRef

van Eden WJ, Kok NFM, Snaebjornsson P, et al. Factors influencing long-term survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei originating from appendiceal neoplasms. BJS Open. 2019;3(3):376–386.CrossRef

Nikiforchin A, King MC, Baron E, et al. Impact of mucin cellularity and distribution on survival in newly diagnosed patients with low-grade appendiceal mucinous neoplasm treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2020. https://doi.org/10.1245/s10434-020-08535-1

Title: ASO Author Reflections: Not All Low-Grade Appendiceal Mucinous Neoplasm Mucin is Created Equal
Authors: Andrei Nikiforchin, MD
Vadim Gushchin, MD, FACS
Mary Caitlin King, BS
Armando Sardi, MD, FACS
Publication date: 01-12-2020
Publisher: Springer International Publishing
Published in: Annals of Surgical Oncology / Issue 13/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-020-08604-5

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ASO Author Reflections: Not All Low-Grade Appendiceal Mucinous Neoplasm Mucin is Created Equal

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