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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2019

Open Access 01-12-2019 | ASO Author Reflections

ASO Author Reflections: Multimodality Treatment in Esophageal Signet Ring Cell Adenocarcinoma

Authors: Sander J. M. van Hootegem, BSc, Bas. P. L. Wijnhoven, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2019

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Excerpt

The aggressive and infiltrating behaviour of signet ring cell (SRC) tumours may be associated with poor prognosis.1 Although multimodality treatment has become the standard of care for oesophageal and junctional adenocarcinoma, the role of neoadjuvant therapy has been under debate for SRC tumours. Still little is known about the exact impact of SRC histology on the efficacy of multimodality treatment in oesophageal and junctional adenocarcinoma.1,2 We, therefore, assessed the impact of SRC histology on response to neoadjuvant therapy and survival. …
Literature
1.
Nafteux PR, Lerut TE, Villeneuve PJ, et al. Signet ring cells in esophageal and gastroesophageal junction carcinomas have a more aggressive biological behavior. Ann Surg. 2014;260(6):1023–9.CrossRef
2.
Bleaney CW, Barrow M, Hayes S, Ang Y. The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus. J Clin Pathol. 2018;71(3):201-6.CrossRef
3.
van Hootegem SJM, Smithers BM, Gotley DC, et al. The impact of signet ring cell differentiation on outcome in patients with oesophageal and gastro-oesophageal junction adenocarcinoma. Ann Surg Oncol. 2019;26:2375–84.CrossRef
4.
Bekkar S, Gronnier C, Messager M, et al. The impact of preoperative radiochemotherapy on survival in advanced esophagogastric junction signet ring cell adenocarcinoma. Ann Thorac Surg. 2014;97(1):303–10.CrossRef
Metadata
Title
ASO Author Reflections: Multimodality Treatment in Esophageal Signet Ring Cell Adenocarcinoma
Authors
Sander J. M. van Hootegem, BSc
Bas. P. L. Wijnhoven, MD, PhD
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07924-5

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