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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2018

01-12-2018 | ASO Author Reflections

ASO Author Reflections: Immunoinflammatory Prognostics in Cancer

Authors: Yusuke Ishibashi, MD, Hironori Tsujimoto, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2018

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Excerpt

Recently, an increasing number of studies have reported that systemic inflammatory responses and nutritional status have indicated long-term outcome in various malignancies.1‐3 In esophageal cancer, although many authors reported that inflammatory and nutritional markers such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) to albumin (Alb) ratio (CAR), and systemic immune-inflammatory index (SII) had good prognostic value, the best predictor for long-term outcome after potentially curative esophagectomy remains controversial.4,5 Furthermore, which factor constituting these markers has the most prognostic value remains unclear. Therefore, our study6 focused on the prognostic value of various preoperative systemic immuno-inflammatory markers, including NLR, PLR, CAR, and SII, for esophageal cancer. We indicated which factor constituting these markers, such as the number of neutrophil, platelet, lymphocyte, and serum levels of CRP and Alb, had the most prognostic value. In addition, we disclosed the relationships between PLR and antiplatelet (anticoagulant) therapies. …
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Kubo T, Ono S, Ueno H et al. Impact of the perioperative neutrophil-to-lymphocyte ratio on the long-term survival following an elective resection of colorectal carcinoma. Int J Colorectal Dis. 2014;29:1091–1099.CrossRefPubMed
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Kishi Y, Kopetz S, Chun YS et al. Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol. 2009;16:614–622.CrossRefPubMed
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Sharaiha RZ, Halazun KJ, Mirza F et al. Elevated preoperative neutrophil: lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol. 2011;18:3362–3369.CrossRefPubMedPubMedCentral
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Wei X-L, Wang F-H, Zhang D-S, et al. A novel inflammation-based prognostic score in esophageal squamous cell carcinoma: the C-reactive protein/albumin ratio. BMC Cancer. 2015;15:350.CrossRefPubMedPubMedCentral
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Ishibashi Y, Tsujimoto H, Hiraki S, et al. Prognostic value of preoperative systemic immunoinflammatory measures in patients with esophageal cancer. Ann Surg Oncol. 2018;25:3288–3299.CrossRefPubMed
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Dutta S, Crumley AB, Fullarton GM, et al. Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative resection of gastric cancer. Am J Surg. 2012;204:294–299.CrossRefPubMed
Metadata
Title
ASO Author Reflections: Immunoinflammatory Prognostics in Cancer
Authors
Yusuke Ishibashi, MD
Hironori Tsujimoto, MD, PhD
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6870-2

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