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01-04-2012 | Commentary

Asking the right questions: the relationship between incident ventilator-associated pneumonia and mortality

Authors: Michael J Lanspa, Samuel M Brown

Published in: Critical Care | Issue 2/2012

Abstract

Whether ventilator-associated pneumonia is a manifestation of severity of illness or an independent cause of mortality in ventilator-dependent patients is not known. In this complex area, which cannot be readily subjected to randomized controlled trials, studies should focus on the underlying questions of relevance, how to improve care of ventilated patients.

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Forel JM, Voillet F, Pulina D, Gaucouin A, Perrin G, Barrau K, Jaber S, Arnal JM, Fathallah M, Auquier P, Roch A, Azoulay E, Papazian L: Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy. Crit Care 2012, 16: R65. 10.1186/cc11312PubMedCentralCrossRefPubMed

Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, Constantin JM, Courant P, Lefrant JY, Guérin C, Prat G, Morange S, Roch A, ACURASYS Study Investigators: Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010, 363: 1107-1116. 10.1056/NEJMoa1005372CrossRefPubMed

Melsen WG, Rovers MM, Bonten MJ: Ventilator-associated pneumonia and mortality: a systematic review of observational studies. Crit Care Med 2009, 37: 2709-2718. 10.1097/CCM.0b013e3181ab8655CrossRefPubMed

Craven DE, Hjalmarson KI: Ventilator-associated tracheobronchitis and pneumonia: thinking outside the box. Clin Infect Dis 2010,51(Suppl 1):S59-66.CrossRefPubMed

Markowicz P, Wolff M, Djedaïni K, Cohen Y, Chastre J, Delclaux C, Merrer J, Herman B, Veber B, Fontaine A, Dreyfuss D: Multicenter prospective study of ventilator-associated pneumonia during acute respiratory distress syndrome. Incidence, prognosis, and risk factors. ARDS Study Group. Am J Respir Crit Care Med 2000, 161: 1942-1948.CrossRefPubMed

Sutherland KR, Steinberg KP, Maunder RJ, Milberg JA, Allen DL, Hudson LD: Pulmonary infection during the acute respiratory distress syndrome. Am J Respir Crit Care Med 1995, 152: 550-556.CrossRefPubMed

Meduri GU, Reddy RC, Stanley T, El-Zeky F: Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling. Am J Respir Crit Care Med 1998, 158: 870-875.CrossRefPubMed

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network N Engl J Med 2000, 342: 1301-1308.

Cook DJ, Walter SD, Cook RJ, Griffith LE, Guyatt GH, Leasa D, Jaeschke RZ, Brun-Buisson C: Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 1998, 129: 433-440.CrossRefPubMed

10.

Wolkewitz M, Allignol A, Schumacher M, Beyersmann J: Two pitfalls in survival analyses of time-dependent exposure: a case study in a cohort of oscar nominees. Am Stat 2010, 64: 205-211. 10.1198/tast.2010.08259CrossRef

Title: Asking the right questions: the relationship between incident ventilator-associated pneumonia and mortality
Authors: Michael J Lanspa
Samuel M Brown
Publication date: 01-04-2012
Publisher: BioMed Central
Published in: Critical Care / Issue 2/2012
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc11308

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Asking the right questions: the relationship between incident ventilator-associated pneumonia and mortality

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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