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Critical Care
Published in: Critical Care 5/2014

Open Access 01-10-2014 | Editorial

Is nosocomial infection really the major cause of death in sepsis?

Authors: Neil M Goldenberg, Aleksandra Leligdowicz, Arthur S Slutsky, Jan O Friedrich, Warren L Lee

Published in: Critical Care | Issue 5/2014

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Abstract

No abstract.
Appendix
Available only for authorised users
Literature
1.
Otto GP, Sossdorf M, Claus RA, Rödel J, Menge K, Reinhart K, Bauer M, Riedemann NC: The late phase of sepsis is characterized by an increased microbiological burden and death rate.Crit Care 2011, 15:R183.,
2.
Riedemann NC, Guo R-F, Ward PA: Novel strategies for the treatment of sepsis. Nat Med. 2003, 9: 517-524. 10.1038/nm0503-517.CrossRef
3.
Hotchkiss RS, Monneret G, Payen D: Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis. 2013, 13: 260-268. 10.1016/S1473-3099(13)70001-X.CrossRef
4.
Abraham E, Wunderink R, Silverman H, Perl TM, Nasraway S, Levy H, Bone R, Wenzel RP, Balk R, Allred R: Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA. 1995, 273: 934-941. 10.1001/jama.1995.03520360048038.CrossRef
5.
Bone RC, Fisher CJ, Clemmer TP, Slotman GJ, Metz CA, Balk RA: A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med. 1987, 317: 653-658. 10.1056/NEJM198709103171101.CrossRef
6.
Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS: Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. 2011, 306: 2594-2605. 10.1001/jama.2011.1829.CrossRef
7.
Hotchkiss RS, Monneret G, Payen D: Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol. 2013, 13: 862-874. 10.1038/nri3552.CrossRef
8.
Payen D, Monneret G, Hotchkiss R: Immunotherapy - a potential new way forward in the treatment of sepsis.Crit Care 2013, 17:118.,
9.
Unsinger J, Kazama H, McDonough JS, Griffith TS, Hotchkiss RS, Ferguson TA: Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol. 2010, 184: 6766-6772. 10.4049/jimmunol.0904054.CrossRef
10.
Torgersen C, Moser P, Luckner G, Mayr V, Jochberger S, Hasibeder WR, Dünser MW: Macroscopic postmortem findings in 235 surgical intensive care patients with sepsis. Anesth Analg. 2009, 108: 1841-1847. 10.1213/ane.0b013e318195e11d.CrossRef
11.
Singer M: The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence. 2014, 5: 66-72. 10.4161/viru.26907.CrossRef
12.
Singer M: Powering up failed organs. Am J Respir Crit Care Med. 2007, 176: 733-734. 10.1164/rccm.200707-964ED.CrossRef
13.
Belikova I, Lukaszewicz AC, Faivre V, Damoisel C, Singer M, Payen D: Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis. Crit Care Med. 2007, 35: 2702-2708. 10.1097/01.CCM.0000295593.25106.C4.CrossRef
14.
Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M: Association between mitochondrial dysfunction and severity and outcome of septic shock. The Lancet. 2002, 360: 219-223. 10.1016/S0140-6736(02)09459-X.CrossRef
15.
Lee WL, Slutsky AS: Sepsis and endothelial permeability. N Engl J Med. 2010, 363: 689-691. 10.1056/NEJMcibr1007320.CrossRef
16.
Goldenberg NM, Steinberg BE, Slutsky AS, Lee WL: Broken barriers: a new take on sepsis pathogenesis.Sci Transl Med 2011, 3:88ps25.,
17.
London NR, Zhu W, Bozza FA, Smith MCP, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY: Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza.Sci Transl Med 2010, 2:23ra19.,
18.
Kümpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park J-K, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N: The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.Crit Care 2011, 15:R261.,
19.
Heart N, Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, DeBoisblanc B, Connors AF, Hite RD, Harabin AL: Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006, 354: 2564-2575. 10.1056/NEJMoa062200.CrossRef
20.
Boyd JH, Forbes J, Nakada T-A, Walley KR, Russell JA: Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011, 39: 259-265. 10.1097/CCM.0b013e3181feeb15.CrossRef
21.
Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, Fanizza C, Caspani L, Faenza S, Grasselli G, Iapichino G, Antonelli M, Parrini V, Fiore G, Latini R, Gattinoni L, ALBIOS Study Investigators: Albumin replacement in patients with severe sepsis or septic shock.N Engl J Med 2014, 371:84.,
22.
Riedemann NC, Guo R-F, Ward PA: The enigma of sepsis. J Clin Invest. 2003, 112: 460-467. 10.1172/JCI200319523.CrossRef
23.
Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H, Reinke P, Volk H-D: Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med. 2009, 180: 640-648. 10.1164/rccm.200903-0363OC.CrossRef
Metadata
Title
Is nosocomial infection really the major cause of death in sepsis?
Authors
Neil M Goldenberg
Aleksandra Leligdowicz
Arthur S Slutsky
Jan O Friedrich
Warren L Lee
Publication date
01-10-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-014-0540-y

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