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Published in: Implementation Science 1/2018

Open Access 01-12-2018 | Commentary

Implementation science in resource-poor countries and communities

Authors: H. Manisha Yapa, Till Bärnighausen

Published in: Implementation Science | Issue 1/2018

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Abstract

Background

Implementation science in resource-poor countries and communities is arguably more important than implementation science in resource-rich settings, because resource poverty requires novel solutions to ensure that research results are translated into routine practice and benefit the largest possible number of people.

Methods

We reviewed the role of resources in the extant implementation science frameworks and literature. We analyzed opportunities for implementation science in resource-poor countries and communities, as well as threats to the realization of these opportunities.

Results

Many of the frameworks that provide theoretical guidance for implementation science view resources as contextual factors that are important to (i) predict the feasibility of implementation of research results in routine practice, (ii) explain implementation success and failure, (iii) adapt novel evidence-based practices to local constraints, and (iv) design the implementation process to account for local constraints. Implementation science for resource-poor settings shifts this view from “resources as context” to “resources as primary research object.” We find a growing body of implementation research aiming to discover and test novel approaches to generate resources for the delivery of evidence-based practice in routine care, including approaches to create higher-skilled health workers—through tele-education and telemedicine, freeing up higher-skilled health workers—through task-shifting and new technologies and models of care, and increasing laboratory capacity through new technologies and the availability of medicines through supply chain innovations. In contrast, only few studies have investigated approaches to change the behavior and utilization of healthcare resources in resource-poor settings. We identify three specific opportunities for implementation science in resource-poor settings. First, intervention and methods innovations thrive under constraints. Second, reverse innovation transferring novel approaches from resource-poor to research-rich settings will gain in importance. Third, policy makers in resource-poor countries tend to be open for close collaboration with scientists in implementation research projects aimed at informing national and local policy.

Conclusions

Implementation science in resource-poor countries and communities offers important opportunities for future discoveries and reverse innovation. To harness this potential, funders need to strongly support research projects in resource-poor settings, as well as the training of the next generation of implementation scientists working on new ways to create healthcare resources where they lack most and to ensure that those resources are utilized to deliver care that is based on the latest research results.
Literature
1.
go back to reference Nolte E, McKee M. Does healthcare save lives? Avoidable mortality revisited. London: Nuffield Trust; 2004. Nolte E, McKee M. Does healthcare save lives? Avoidable mortality revisited. London: Nuffield Trust; 2004.
2.
go back to reference GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet. 2017;390(10091):231–66.CrossRef GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet. 2017;390(10091):231–66.CrossRef
4.
go back to reference World Bank Group. Africa’s pulse, No. 16. Washington, DC: World Bank; 2017. World Bank Group. Africa’s pulse, No. 16. Washington, DC: World Bank; 2017.
5.
go back to reference The Equality Trust. The cost of inequality. London: The Equality Trust; 2014. The Equality Trust. The cost of inequality. London: The Equality Trust; 2014.
6.
go back to reference WHO. The Abuja Declaration ten years on. Geneva: WHO; 2011. WHO. The Abuja Declaration ten years on. Geneva: WHO; 2011.
7.
go back to reference Nattrass N, Hodes R, Cluver L. Changing donor funding and the challenges of integrated HIV treatment. AMA J Ethics. 2016;18(7):681–90.PubMedCrossRef Nattrass N, Hodes R, Cluver L. Changing donor funding and the challenges of integrated HIV treatment. AMA J Ethics. 2016;18(7):681–90.PubMedCrossRef
8.
go back to reference Banks N, Hulme D, Edwards M. NGOs, states, and donors revisited: still too close for comfort? World Dev. 2014;66:707–18.CrossRef Banks N, Hulme D, Edwards M. NGOs, states, and donors revisited: still too close for comfort? World Dev. 2014;66:707–18.CrossRef
11.
go back to reference Cochrane LJ, Olson CA, Murray S, Dupuis M, Tooman T, Hayes S. Gaps between knowing and doing: understanding and assessing the barriers to optimal health care. J Contin Educ Heal Prof. 2007;27(2):94–102.CrossRef Cochrane LJ, Olson CA, Murray S, Dupuis M, Tooman T, Hayes S. Gaps between knowing and doing: understanding and assessing the barriers to optimal health care. J Contin Educ Heal Prof. 2007;27(2):94–102.CrossRef
12.
go back to reference Durlak JA, DuPre EP. Implementation matters: a review of research on the influence of implementation on program outcomes and the factors affecting implementation. Am J Community Psychol. 2008;41(3–4):327–50.PubMedCrossRef Durlak JA, DuPre EP. Implementation matters: a review of research on the influence of implementation on program outcomes and the factors affecting implementation. Am J Community Psychol. 2008;41(3–4):327–50.PubMedCrossRef
13.
go back to reference Gurses AP, Marsteller JA, Ozok AA, Xiao Y, Owens S, Pronovost PJ. Using an interdisciplinary approach to identify factors that affect clinicians’ compliance with evidence-based guidelines. Crit Care Med. 2010;38(8 Suppl):S282–91.PubMedCrossRef Gurses AP, Marsteller JA, Ozok AA, Xiao Y, Owens S, Pronovost PJ. Using an interdisciplinary approach to identify factors that affect clinicians’ compliance with evidence-based guidelines. Crit Care Med. 2010;38(8 Suppl):S282–91.PubMedCrossRef
14.
go back to reference Huberman M. Research utilization: the state of the art. Knowl Policy. 1994;7(4):13–33.CrossRef Huberman M. Research utilization: the state of the art. Knowl Policy. 1994;7(4):13–33.CrossRef
15.
go back to reference Davis SM, Peterson JC, Helfrich CD, Cunningham-Sabo L. Introduction and conceptual model for utilization of prevention research. Am J Prev Med. 2007;33(1 Suppl):S1–5.PubMedCrossRef Davis SM, Peterson JC, Helfrich CD, Cunningham-Sabo L. Introduction and conceptual model for utilization of prevention research. Am J Prev Med. 2007;33(1 Suppl):S1–5.PubMedCrossRef
16.
go back to reference Stetler CB. Refinement of the Stetler/Marram model for application of research findings to practice. Nurs Outlook. 1994;42(1):15–25.PubMedCrossRef Stetler CB. Refinement of the Stetler/Marram model for application of research findings to practice. Nurs Outlook. 1994;42(1):15–25.PubMedCrossRef
17.
go back to reference Logan J, Graham I. Toward a comprehensive interdisciplinary model of health care research use. Sci Commun. 1998;20:227–46.CrossRef Logan J, Graham I. Toward a comprehensive interdisciplinary model of health care research use. Sci Commun. 1998;20:227–46.CrossRef
18.
go back to reference Grol R, Wensing M. What drives change? Barriers to and incentives for achieving evidence-based practice. Med J Aust. 2004;180(6 Suppl):S57–60.PubMed Grol R, Wensing M. What drives change? Barriers to and incentives for achieving evidence-based practice. Med J Aust. 2004;180(6 Suppl):S57–60.PubMed
19.
go back to reference Pronovost PJ, Berenholtz SM, Needham DM. Translating evidence into practice: a model for large scale knowledge translation. BMJ. 2008;337:a1714.PubMedCrossRef Pronovost PJ, Berenholtz SM, Needham DM. Translating evidence into practice: a model for large scale knowledge translation. BMJ. 2008;337:a1714.PubMedCrossRef
20.
go back to reference Field B, Booth A, Ilott I, Gerrish K. Using the knowledge to action framework in practice: a citation analysis and systematic review. Implement Sci. 2014;9:172.PubMedPubMedCentralCrossRef Field B, Booth A, Ilott I, Gerrish K. Using the knowledge to action framework in practice: a citation analysis and systematic review. Implement Sci. 2014;9:172.PubMedPubMedCentralCrossRef
21.
go back to reference Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.PubMedPubMedCentralCrossRef Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.PubMedPubMedCentralCrossRef
22.
go back to reference Kitson AL, Rycroft-Malone J, Harvey G, McCormack B, Seers K, Titchen A. Evaluating the successful implementation of evidence into practice using the PARiHS framework: theoretical and practical challenges. Implement Sci. 2008;3:1.PubMedPubMedCentralCrossRef Kitson AL, Rycroft-Malone J, Harvey G, McCormack B, Seers K, Titchen A. Evaluating the successful implementation of evidence into practice using the PARiHS framework: theoretical and practical challenges. Implement Sci. 2008;3:1.PubMedPubMedCentralCrossRef
23.
go back to reference Meyers DC, Durlak JA, Wandersman A. The quality implementation framework: a synthesis of critical steps in the implementation process. Am J Community Psychol. 2012;50(3–4):462–80.PubMedCrossRef Meyers DC, Durlak JA, Wandersman A. The quality implementation framework: a synthesis of critical steps in the implementation process. Am J Community Psychol. 2012;50(3–4):462–80.PubMedCrossRef
24.
go back to reference Greenhalgh T, Robert G, Macfarlane F, Bate P, Kyriakidou O. Diffusion of innovations in service organizations: systematic review and recommendations. Milbank Q. 2004;82(4):581–629.PubMedPubMedCentralCrossRef Greenhalgh T, Robert G, Macfarlane F, Bate P, Kyriakidou O. Diffusion of innovations in service organizations: systematic review and recommendations. Milbank Q. 2004;82(4):581–629.PubMedPubMedCentralCrossRef
26.
go back to reference May C, Finch T, Mair F, Ballini L, Dowrick C, Eccles M, Gask L, MacFarlane A, Murray E, Rapley T, et al. Understanding the implementation of complex interventions in health care: the normalization process model. BMC Health Serv Res. 2007;7:148.PubMedPubMedCentralCrossRef May C, Finch T, Mair F, Ballini L, Dowrick C, Eccles M, Gask L, MacFarlane A, Murray E, Rapley T, et al. Understanding the implementation of complex interventions in health care: the normalization process model. BMC Health Serv Res. 2007;7:148.PubMedPubMedCentralCrossRef
27.
go back to reference May CR, Mair F, Finch T, MacFarlane A, Dowrick C, Treweek S, Rapley T, Ballini L, Ong BN, Rogers A, et al. Development of a theory of implementation and integration: normalization process theory. Implement Sci. 2009;4:29.PubMedPubMedCentralCrossRef May CR, Mair F, Finch T, MacFarlane A, Dowrick C, Treweek S, Rapley T, Ballini L, Ong BN, Rogers A, et al. Development of a theory of implementation and integration: normalization process theory. Implement Sci. 2009;4:29.PubMedPubMedCentralCrossRef
28.
go back to reference Stetler CB. Stetler model. In: Rycroft-Malone J, Bucknall T, editors. Models and frameworks for implementing evidence-based practice: linking evidence to action. Oxford: Wiley-Blackwell; 2010. p. 51–82. Stetler CB. Stetler model. In: Rycroft-Malone J, Bucknall T, editors. Models and frameworks for implementing evidence-based practice: linking evidence to action. Oxford: Wiley-Blackwell; 2010. p. 51–82.
29.
go back to reference Finch TL, Rapley T, Girling M, Mair FS, Murray E, Treweek S, McColl E, Steen IN, May CR. Improving the normalization of complex interventions: measure development based on normalization process theory (NoMAD): study protocol. Implement Sci. 2013;8:43.PubMedPubMedCentralCrossRef Finch TL, Rapley T, Girling M, Mair FS, Murray E, Treweek S, McColl E, Steen IN, May CR. Improving the normalization of complex interventions: measure development based on normalization process theory (NoMAD): study protocol. Implement Sci. 2013;8:43.PubMedPubMedCentralCrossRef
30.
go back to reference Flottorp SA, Oxman AD, Krause J, Musila NR, Wensing M, Godycki-Cwirko M, Baker R, Eccles MP. A checklist for identifying determinants of practice: a systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice. Implement Sci. 2013;8:35.PubMedPubMedCentralCrossRef Flottorp SA, Oxman AD, Krause J, Musila NR, Wensing M, Godycki-Cwirko M, Baker R, Eccles MP. A checklist for identifying determinants of practice: a systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice. Implement Sci. 2013;8:35.PubMedPubMedCentralCrossRef
31.
go back to reference Santesso N, Tugwell P. Knowledge translation in developing countries. J Contin Educ Heal Prof. 2006;26(1):87–96.CrossRef Santesso N, Tugwell P. Knowledge translation in developing countries. J Contin Educ Heal Prof. 2006;26(1):87–96.CrossRef
32.
go back to reference World Health Organization. Global strategy on human resources for health: workforce 2030. Geneva: WHO; 2016. World Health Organization. Global strategy on human resources for health: workforce 2030. Geneva: WHO; 2016.
33.
go back to reference De Neve JW, Garrison-Desany H, Andrews KG, Sharara N, Boudreaux C, Gill R, Geldsetzer P, Vaikath M, Bärnighausen T, Bossert TJ. Harmonization of community health worker programs for HIV: a four-country qualitative study in Southern Africa. PLoS Med. 2017;14(8):e1002374.PubMedPubMedCentralCrossRef De Neve JW, Garrison-Desany H, Andrews KG, Sharara N, Boudreaux C, Gill R, Geldsetzer P, Vaikath M, Bärnighausen T, Bossert TJ. Harmonization of community health worker programs for HIV: a four-country qualitative study in Southern Africa. PLoS Med. 2017;14(8):e1002374.PubMedPubMedCentralCrossRef
34.
go back to reference Kumar M, Nefdt R, Ribaira E, Diallo K. Access to healthcare through community health workers in East and Southern Africa. New York: UNICEF; 2014. Kumar M, Nefdt R, Ribaira E, Diallo K. Access to healthcare through community health workers in East and Southern Africa. New York: UNICEF; 2014.
35.
go back to reference Tulenko K, Mogedal S, Afzal MM, Frymus D, Oshin A, Pate M, Quain E, Pinel A, Wynd S, Zodpey S. Community health workers for universal health-care coverage: from fragmentation to synergy. Bull World Health Organ. 2013;91(11):847–52.PubMedPubMedCentralCrossRef Tulenko K, Mogedal S, Afzal MM, Frymus D, Oshin A, Pate M, Quain E, Pinel A, Wynd S, Zodpey S. Community health workers for universal health-care coverage: from fragmentation to synergy. Bull World Health Organ. 2013;91(11):847–52.PubMedPubMedCentralCrossRef
38.
go back to reference Maher D, Cometto G. Research on community-based health workers is needed to achieve the sustainable development goals. Bull World Health Organ. 2016;94(11):786.PubMedPubMedCentralCrossRef Maher D, Cometto G. Research on community-based health workers is needed to achieve the sustainable development goals. Bull World Health Organ. 2016;94(11):786.PubMedPubMedCentralCrossRef
39.
go back to reference Pantoja T, Opiyo N, Lewin S, Paulsen E, Ciapponi A, Wiysonge CS, Herrera CA, Rada G, Peñaloza B, Dudley L, et al. Implementation strategies for health systems in low-income countries: an overview of systematic reviews. Cochrane Database Syst Rev. 2017;9:CD011086.PubMed Pantoja T, Opiyo N, Lewin S, Paulsen E, Ciapponi A, Wiysonge CS, Herrera CA, Rada G, Peñaloza B, Dudley L, et al. Implementation strategies for health systems in low-income countries: an overview of systematic reviews. Cochrane Database Syst Rev. 2017;9:CD011086.PubMed
40.
go back to reference Giguere A, Legare F, Grimshaw J, Turcotte S, Fiander M, Grudniewicz A, Makosso-Kallyth S, Wolf FM, Farmer AP, Gagnon MP. Printed educational materials: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2012;10:CD004398.PubMed Giguere A, Legare F, Grimshaw J, Turcotte S, Fiander M, Grudniewicz A, Makosso-Kallyth S, Wolf FM, Farmer AP, Gagnon MP. Printed educational materials: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2012;10:CD004398.PubMed
41.
go back to reference Cook DA, Levinson AJ, Garside S, Dupras DM, Erwin PJ, Montori VM. Internet-based learning in the health professions: a meta-analysis. J Am Med Assoc. 2008;300:1181–96.CrossRef Cook DA, Levinson AJ, Garside S, Dupras DM, Erwin PJ, Montori VM. Internet-based learning in the health professions: a meta-analysis. J Am Med Assoc. 2008;300:1181–96.CrossRef
42.
go back to reference Forsetlund L, Bjorndal A, Rashidian A, Jamtvedt G, O'Brien MA, Wolf F, Davis D, Odgaard-Jensen J, Oxman AD. Continuing education meetings and workshops: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2009;2:CD003030. Forsetlund L, Bjorndal A, Rashidian A, Jamtvedt G, O'Brien MA, Wolf F, Davis D, Odgaard-Jensen J, Oxman AD. Continuing education meetings and workshops: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2009;2:CD003030.
43.
go back to reference Reeves S, Perrier L, Goldman J, Freeth D, Zwarenstein M. Interprofessional education: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2013;3:CD002213. Reeves S, Perrier L, Goldman J, Freeth D, Zwarenstein M. Interprofessional education: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2013;3:CD002213.
44.
go back to reference Horsley T, Hyde C, Santesso N, Parkes J, Milne R, Stewart R. Teaching critical appraisal skills in healthcare settings. Cochrane Database Syst Rev. 2011;11:CD001270. Horsley T, Hyde C, Santesso N, Parkes J, Milne R, Stewart R. Teaching critical appraisal skills in healthcare settings. Cochrane Database Syst Rev. 2011;11:CD001270.
45.
go back to reference Sunguya BF, Poudel KC, Mlunde LB, Shakya P, Urassa DP, Jimba M, Yasuoka J. Effectiveness of nutrition training of health workers toward improving caregivers’ feeding practices for children aged six months to two years: a systematic review. Nutr J. 2013;12:66.PubMedPubMedCentralCrossRef Sunguya BF, Poudel KC, Mlunde LB, Shakya P, Urassa DP, Jimba M, Yasuoka J. Effectiveness of nutrition training of health workers toward improving caregivers’ feeding practices for children aged six months to two years: a systematic review. Nutr J. 2013;12:66.PubMedPubMedCentralCrossRef
46.
go back to reference Baskerville NB, Liddy C, Hogg W. Systematic review and meta-analysis of practice facilitation within primary care settings. Ann Fam Med. 2012;10(1):63–74.PubMedPubMedCentralCrossRef Baskerville NB, Liddy C, Hogg W. Systematic review and meta-analysis of practice facilitation within primary care settings. Ann Fam Med. 2012;10(1):63–74.PubMedPubMedCentralCrossRef
47.
go back to reference O'Brien MA, Rogers S, Jamtvedt G, Oxman AD, Odgaard-Jensen J, Kristoffersen DT, Forsetlund L, Bainbridge D, Freemantle N, Davis DA, et al. Educational outreach visits: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2007;4:CD000409. O'Brien MA, Rogers S, Jamtvedt G, Oxman AD, Odgaard-Jensen J, Kristoffersen DT, Forsetlund L, Bainbridge D, Freemantle N, Davis DA, et al. Educational outreach visits: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2007;4:CD000409.
48.
go back to reference Pande S, Hiller JE, Nkansah N, Bero L. The effect of pharmacist-provided non-dispensing services on patient outcomes, health service utilisation and costs in low- and middle-income countries. Cochrane Database Syst Rev. 2013;2:CD010398. Pande S, Hiller JE, Nkansah N, Bero L. The effect of pharmacist-provided non-dispensing services on patient outcomes, health service utilisation and costs in low- and middle-income countries. Cochrane Database Syst Rev. 2013;2:CD010398.
49.
go back to reference Flodgren G, Parmelli E, Doumit G, Gattellari M, O'Brien MA, Grimshaw J, Eccles MP. Local opinion leaders: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2011;8:CD000125. Flodgren G, Parmelli E, Doumit G, Gattellari M, O'Brien MA, Grimshaw J, Eccles MP. Local opinion leaders: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2011;8:CD000125.
50.
go back to reference Ivers N, Jamtvedt G, Flottorp S, Young JM, Odgaard-Jensen J, French SD, O'Brien MA, Johansen M, Grimshaw J, Oxman AD. Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2012, Issue 6. Art. No.: CD000259. Ivers N, Jamtvedt G, Flottorp S, Young JM, Odgaard-Jensen J, French SD, O'Brien MA, Johansen M, Grimshaw J, Oxman AD. Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2012, Issue 6. Art. No.: CD000259.
51.
go back to reference Ko CH, Turner TJ, Finnigan M. Systematic review of safety checklists for use by medical care teams in acute hospital settings - limited evidence for effectiveness. BMC Health Serv Res. 2011;11:211.PubMedPubMedCentralCrossRef Ko CH, Turner TJ, Finnigan M. Systematic review of safety checklists for use by medical care teams in acute hospital settings - limited evidence for effectiveness. BMC Health Serv Res. 2011;11:211.PubMedPubMedCentralCrossRef
52.
go back to reference Baker R, Camosso-Stefinovic J, Gillies C, Shaw EJ, Cheater F, Flottorp S, Robertson N, Wensing M, Fiander M, Eccles MP, et al. Tailored interventions to address determinants of practice. Cochrane Database Syst Rev. 2015;4:CD005470. Baker R, Camosso-Stefinovic J, Gillies C, Shaw EJ, Cheater F, Flottorp S, Robertson N, Wensing M, Fiander M, Eccles MP, et al. Tailored interventions to address determinants of practice. Cochrane Database Syst Rev. 2015;4:CD005470.
53.
go back to reference Perrier L, Mrklas K, Shepperd S, Dobbins M, McKibbon KA, Straus SE. Interventions encouraging the use of systematic reviews in clinical decision-making: a systematic review. J Gen Intern Med. 2011;26(4):419–26.PubMedCrossRef Perrier L, Mrklas K, Shepperd S, Dobbins M, McKibbon KA, Straus SE. Interventions encouraging the use of systematic reviews in clinical decision-making: a systematic review. J Gen Intern Med. 2011;26(4):419–26.PubMedCrossRef
54.
go back to reference Nattrass N. AIDS and the scientific governance of medicine in post-apartheid South Africa. Afr Aff. 2008;107(427):157–76.CrossRef Nattrass N. AIDS and the scientific governance of medicine in post-apartheid South Africa. Afr Aff. 2008;107(427):157–76.CrossRef
55.
56.
go back to reference Balabanova D, Mills A, Conteh L, Akkazieva B, Banteyerga H, Dash U, Gilson L, Harmer A, Ibraimova A, Islam Z, et al. Good health at low cost 25 years on: lessons for the future of health systems strengthening. Lancet. 2013;381(9883):2118–33.PubMedCrossRef Balabanova D, Mills A, Conteh L, Akkazieva B, Banteyerga H, Dash U, Gilson L, Harmer A, Ibraimova A, Islam Z, et al. Good health at low cost 25 years on: lessons for the future of health systems strengthening. Lancet. 2013;381(9883):2118–33.PubMedCrossRef
57.
go back to reference Gibbert M, Hoegl M, Välikangas L. In praise of resource constraints. MIT Sloan Manag Rev. 2007;48(3):15. Gibbert M, Hoegl M, Välikangas L. In praise of resource constraints. MIT Sloan Manag Rev. 2007;48(3):15.
58.
go back to reference Moreau C, Dahl D. Designing the solution: the impact of constraints on consumers’ creativity. J Consum Res. 2005;32:13–22.CrossRef Moreau C, Dahl D. Designing the solution: the impact of constraints on consumers’ creativity. J Consum Res. 2005;32:13–22.CrossRef
59.
go back to reference Sellier A, Dahl D. Focus! Creativity is enjoyed through restricted choice. J Mark Res. 2011;48(December):996–1007.CrossRef Sellier A, Dahl D. Focus! Creativity is enjoyed through restricted choice. J Mark Res. 2011;48(December):996–1007.CrossRef
60.
go back to reference Dahl D, Moreau C. Thinking inside the box: why consumers enjoy constrained creative experiences. J Mark Res. 2007;44(August):357–69.CrossRef Dahl D, Moreau C. Thinking inside the box: why consumers enjoy constrained creative experiences. J Mark Res. 2007;44(August):357–69.CrossRef
61.
go back to reference Grimsrud A, Sharp J, Kalombo C, Bekker L-G, Myer L. Implementation of community-based adherence clubs for stable antiretroviral therapy patients in Cape Town, South Africa. J Int AIDS Soc. 2015;18(1):19984.PubMedPubMedCentralCrossRef Grimsrud A, Sharp J, Kalombo C, Bekker L-G, Myer L. Implementation of community-based adherence clubs for stable antiretroviral therapy patients in Cape Town, South Africa. J Int AIDS Soc. 2015;18(1):19984.PubMedPubMedCentralCrossRef
62.
go back to reference Grimsrud A, Lesosky M, Kalombo C, Bekker LG, Myer L. Implementation and operational research: community-based adherence clubs for the management of stable antiretroviral therapy patients in Cape Town, South Africa: a cohort study. J Acquir Immune Defic Syndr. 2016;71(1):e16–23.PubMed Grimsrud A, Lesosky M, Kalombo C, Bekker LG, Myer L. Implementation and operational research: community-based adherence clubs for the management of stable antiretroviral therapy patients in Cape Town, South Africa: a cohort study. J Acquir Immune Defic Syndr. 2016;71(1):e16–23.PubMed
63.
go back to reference Wilkinson LS. ART adherence clubs: a long-term retention strategy for clinically stable patients receiving antiretroviral therapy. South Afr J HIV Med. 2013;14(2):48.CrossRef Wilkinson LS. ART adherence clubs: a long-term retention strategy for clinically stable patients receiving antiretroviral therapy. South Afr J HIV Med. 2013;14(2):48.CrossRef
64.
go back to reference Tshuma N, Mosikare O, Yun JA, Alaba OA, Maheedhariah MS, Muloongo K, Nyasulu PS. Acceptability of community-based adherence clubs among health facility staff in South Africa: a qualitative study. Patient Prefer Adherence. 2017;11:1523–31.PubMedPubMedCentralCrossRef Tshuma N, Mosikare O, Yun JA, Alaba OA, Maheedhariah MS, Muloongo K, Nyasulu PS. Acceptability of community-based adherence clubs among health facility staff in South Africa: a qualitative study. Patient Prefer Adherence. 2017;11:1523–31.PubMedPubMedCentralCrossRef
65.
go back to reference Venables E, Edwards JK, Baert S, Etienne W, Khabala K, Bygrave H. “They just come, pick and go.” The acceptability of integrated medication adherence clubs for HIV and non communicable disease (NCD) patients in Kibera, Kenya. PLoS One. 2016;11(10):e0164634.PubMedPubMedCentralCrossRef Venables E, Edwards JK, Baert S, Etienne W, Khabala K, Bygrave H. “They just come, pick and go.” The acceptability of integrated medication adherence clubs for HIV and non communicable disease (NCD) patients in Kibera, Kenya. PLoS One. 2016;11(10):e0164634.PubMedPubMedCentralCrossRef
66.
go back to reference Decroo T, Koole O, Remartinez D, dos Santos N, Dezembro S, Jofrisse M, Rasschaert F, Biot M, Laga M. Four-year retention and risk factors for attrition among members of community ART groups in Tete, Mozambique. Tropical Med Int Health. 2014;19(5):514–21.CrossRef Decroo T, Koole O, Remartinez D, dos Santos N, Dezembro S, Jofrisse M, Rasschaert F, Biot M, Laga M. Four-year retention and risk factors for attrition among members of community ART groups in Tete, Mozambique. Tropical Med Int Health. 2014;19(5):514–21.CrossRef
67.
go back to reference Friends of the Global Fight against AIDS TaM. The case for U.S. investment in the Global Fund and Global Health. Washington, DC: theglobalfght.org; 2017. Friends of the Global Fight against AIDS TaM. The case for U.S. investment in the Global Fund and Global Health. Washington, DC: theglobalfght.org; 2017.
68.
go back to reference McVeigh T. South Africa’s latest weapon against HIV: street dispensers for antiretrovirals. In: The Guardian; 2016. McVeigh T. South Africa’s latest weapon against HIV: street dispensers for antiretrovirals. In: The Guardian; 2016.
69.
go back to reference Rosen JW. Zipline’s ambitious medical drone delivery in Africa. In: MIT technology review; 2017. Rosen JW. Zipline’s ambitious medical drone delivery in Africa. In: MIT technology review; 2017.
70.
go back to reference Gaffey C. Drones will fly HIV drugs and vaccines across Tanzania in biggest national delivery network. In: Newsweek; 2017. Gaffey C. Drones will fly HIV drugs and vaccines across Tanzania in biggest national delivery network. In: Newsweek; 2017.
71.
go back to reference Suwamaru JK. An SMS-based HIV/AIDS education and awareness model for rural areas in Papua New Guinea. Stud Health Technol Inform. 2012;182:161–9.PubMed Suwamaru JK. An SMS-based HIV/AIDS education and awareness model for rural areas in Papua New Guinea. Stud Health Technol Inform. 2012;182:161–9.PubMed
72.
go back to reference Phillips KA, Epstein DH, Mezghanni M, Vahabzadeh M, Reamer D, Agage D, Preston KL. Smartphone delivery of mobile HIV risk reduction education. AIDS Res Treat. 2013;2013:231956.PubMedPubMedCentral Phillips KA, Epstein DH, Mezghanni M, Vahabzadeh M, Reamer D, Agage D, Preston KL. Smartphone delivery of mobile HIV risk reduction education. AIDS Res Treat. 2013;2013:231956.PubMedPubMedCentral
73.
go back to reference Jennings L, Ong’ech J, Simiyu R, Sirengo M, Kassaye S. Exploring the use of mobile phone technology for the enhancement of the prevention of mother-to-child transmission of HIV program in Nyanza, Kenya: a qualitative study. BMC Public Health. 2013;13(1):1131.PubMedPubMedCentralCrossRef Jennings L, Ong’ech J, Simiyu R, Sirengo M, Kassaye S. Exploring the use of mobile phone technology for the enhancement of the prevention of mother-to-child transmission of HIV program in Nyanza, Kenya: a qualitative study. BMC Public Health. 2013;13(1):1131.PubMedPubMedCentralCrossRef
74.
go back to reference Blaya JA, Fraser HS, Holt B. E-health technologies show promise in developing countries. Health Aff. 2010;29(2):244–51.CrossRef Blaya JA, Fraser HS, Holt B. E-health technologies show promise in developing countries. Health Aff. 2010;29(2):244–51.CrossRef
75.
go back to reference Mars M. Building the capacity to build capacity in e-health in sub-Saharan Africa: the KwaZulu-Natal experience. Telemed J E Health. 2012;18(1):32–7.PubMedPubMedCentralCrossRef Mars M. Building the capacity to build capacity in e-health in sub-Saharan Africa: the KwaZulu-Natal experience. Telemed J E Health. 2012;18(1):32–7.PubMedPubMedCentralCrossRef
76.
go back to reference Epstein D, Petersiel N, Klein E, Marcusohn E, Aviran E, Harel R, Azzam ZS, Neuberger A, Fuchs L. Pocket-size point-of-care ultrasound in rural Uganda - a unique opportunity “to see”, where no imaging facilities are available. Travel Med Infect Dis. 2018;23:87-93. Epstein D, Petersiel N, Klein E, Marcusohn E, Aviran E, Harel R, Azzam ZS, Neuberger A, Fuchs L. Pocket-size point-of-care ultrasound in rural Uganda - a unique opportunity “to see”, where no imaging facilities are available. Travel Med Infect Dis. 2018;23:87-93.
77.
go back to reference Robbins RN, Gouse H, Brown HG, Ehlers A, Scott TM, Leu CS, Remien RH, Mellins CA, Joska JA. A mobile app to screen for neurocognitive impairment: preliminary validation of NeuroScreen among HIV-infected South African adults. JMIR mHealth uHealth. 2018;6(1):e5.PubMedPubMedCentralCrossRef Robbins RN, Gouse H, Brown HG, Ehlers A, Scott TM, Leu CS, Remien RH, Mellins CA, Joska JA. A mobile app to screen for neurocognitive impairment: preliminary validation of NeuroScreen among HIV-infected South African adults. JMIR mHealth uHealth. 2018;6(1):e5.PubMedPubMedCentralCrossRef
78.
go back to reference van Heerden A, Sen D, Desmond C, Louw J, Richter L. App-supported promotion of child growth and development by community health workers in Kenya: feasibility and acceptability study. JMIR mHealth uHealth. 2017;5(12):e182.PubMedPubMedCentralCrossRef van Heerden A, Sen D, Desmond C, Louw J, Richter L. App-supported promotion of child growth and development by community health workers in Kenya: feasibility and acceptability study. JMIR mHealth uHealth. 2017;5(12):e182.PubMedPubMedCentralCrossRef
79.
go back to reference Bardosh KL, Murray M, Khaemba AM, Smillie K, Lester R. Operationalizing mHealth to improve patient care: a qualitative implementation science evaluation of the WelTel texting intervention in Canada and Kenya. Glob Health. 2017;13(1):87.CrossRef Bardosh KL, Murray M, Khaemba AM, Smillie K, Lester R. Operationalizing mHealth to improve patient care: a qualitative implementation science evaluation of the WelTel texting intervention in Canada and Kenya. Glob Health. 2017;13(1):87.CrossRef
80.
go back to reference Mars M. Telemedicine and advances in urban and rural healthcare delivery in Africa. Prog Cardiovasc Dis. 2013;56(3):326–35.PubMedCrossRef Mars M. Telemedicine and advances in urban and rural healthcare delivery in Africa. Prog Cardiovasc Dis. 2013;56(3):326–35.PubMedCrossRef
81.
go back to reference Govindarajan V, Trimble C. Reverse innovation: create far from home, win everywhere. Boston: Harvard Business Review Press; 2010. Govindarajan V, Trimble C. Reverse innovation: create far from home, win everywhere. Boston: Harvard Business Review Press; 2010.
82.
go back to reference Bhatti Y, Taylor A, Harris M, Wadge H, Escobar E, Prime M, Patel H, Carter AW, Parston G, Darzi AW, et al. Global lessons in frugal innovation to improve health care delivery in the United States. Health Aff. 2017;36(11):1912–9.CrossRef Bhatti Y, Taylor A, Harris M, Wadge H, Escobar E, Prime M, Patel H, Carter AW, Parston G, Darzi AW, et al. Global lessons in frugal innovation to improve health care delivery in the United States. Health Aff. 2017;36(11):1912–9.CrossRef
83.
go back to reference Syed SB, Dadwal V, Rutter P, Storr J, Hightower JD, Gooden R, Carlet J, Nejad SB, Kelley ET, Donaldson L, et al. Developed-developing country partnerships: benefits to developed countries? Glob Health. 2012;8(1):17.CrossRef Syed SB, Dadwal V, Rutter P, Storr J, Hightower JD, Gooden R, Carlet J, Nejad SB, Kelley ET, Donaldson L, et al. Developed-developing country partnerships: benefits to developed countries? Glob Health. 2012;8(1):17.CrossRef
84.
go back to reference The Gambia Hepatits Study Group. The Gambia Hepatitis Intervention Study. Cancer Res. 1987;47:5782–7. The Gambia Hepatits Study Group. The Gambia Hepatitis Intervention Study. Cancer Res. 1987;47:5782–7.
85.
go back to reference Canning D, Shah IH, Pearson E, Pradhan E, Karra M, Senderowicz L, Bärnighausen T, Spiegelman D, Langer A. Institutionalizing postpartum intrauterine device (IUD) services in Sri Lanka, Tanzania, and Nepal: study protocol for a cluster-randomized stepped-wedge trial. BMC Pregnancy Childbirth. 2016;16(1):362.PubMedPubMedCentralCrossRef Canning D, Shah IH, Pearson E, Pradhan E, Karra M, Senderowicz L, Bärnighausen T, Spiegelman D, Langer A. Institutionalizing postpartum intrauterine device (IUD) services in Sri Lanka, Tanzania, and Nepal: study protocol for a cluster-randomized stepped-wedge trial. BMC Pregnancy Childbirth. 2016;16(1):362.PubMedPubMedCentralCrossRef
86.
go back to reference Fink G, Robyn PJ, Sie A, Sauerborn R. Does health insurance improve health?: evidence from a randomized community-based insurance rollout in rural Burkina Faso. J Health Econ. 2013;32(6):1043–56.PubMedCrossRef Fink G, Robyn PJ, Sie A, Sauerborn R. Does health insurance improve health?: evidence from a randomized community-based insurance rollout in rural Burkina Faso. J Health Econ. 2013;32(6):1043–56.PubMedCrossRef
87.
go back to reference Walsh FJ, Bärnighausen T, Delva W, Fleming Y, Khumalo G, Lejeune CL, Mazibuko S, Mlambo CK, Reis R, Spiegelman D, et al. Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system: study protocol for a stepped-wedge randomized trial. Trials. 2017;18(1):383.PubMedPubMedCentralCrossRef Walsh FJ, Bärnighausen T, Delva W, Fleming Y, Khumalo G, Lejeune CL, Mazibuko S, Mlambo CK, Reis R, Spiegelman D, et al. Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system: study protocol for a stepped-wedge randomized trial. Trials. 2017;18(1):383.PubMedPubMedCentralCrossRef
88.
go back to reference Pfeiffer JT, Napua M, Wagenaar BH, Chale F, Hoek R, Micek M, Manuel J, Michel C, Cowan JG, Cowan JF, et al. Stepped-wedge cluster randomized controlled trial to promote option B+ retention in Central Mozambique. J Acquir Immune Defic Syndr. 2017;76(3):273–80.PubMedCrossRef Pfeiffer JT, Napua M, Wagenaar BH, Chale F, Hoek R, Micek M, Manuel J, Michel C, Cowan JG, Cowan JF, et al. Stepped-wedge cluster randomized controlled trial to promote option B+ retention in Central Mozambique. J Acquir Immune Defic Syndr. 2017;76(3):273–80.PubMedCrossRef
89.
go back to reference Praveen D, Patel A, McMahon S, Prabhakaran D, Clifford GD, Maulik PK, Joshi R, Jan S, Heritier S, Peiris D. A multifaceted strategy using mobile technology to assist rural primary healthcare doctors and frontline health workers in cardiovascular disease risk management: protocol for the SMARTHealth India cluster randomised controlled trial. Implement Sci. 2013;8:137.PubMedPubMedCentralCrossRef Praveen D, Patel A, McMahon S, Prabhakaran D, Clifford GD, Maulik PK, Joshi R, Jan S, Heritier S, Peiris D. A multifaceted strategy using mobile technology to assist rural primary healthcare doctors and frontline health workers in cardiovascular disease risk management: protocol for the SMARTHealth India cluster randomised controlled trial. Implement Sci. 2013;8:137.PubMedPubMedCentralCrossRef
90.
go back to reference McGuinness SL, O'Toole JE, Boving TB, Forbes AB, Sinclair M, Gautam SK, Leder K. Protocol for a cluster randomised stepped wedge trial assessing the impact of a community-level hygiene intervention and a water intervention using riverbank filtration technology on diarrhoeal prevalence in India. BMJ Open. 2017;7(3):e015036.PubMedPubMedCentralCrossRef McGuinness SL, O'Toole JE, Boving TB, Forbes AB, Sinclair M, Gautam SK, Leder K. Protocol for a cluster randomised stepped wedge trial assessing the impact of a community-level hygiene intervention and a water intervention using riverbank filtration technology on diarrhoeal prevalence in India. BMJ Open. 2017;7(3):e015036.PubMedPubMedCentralCrossRef
91.
go back to reference World Bank. World development indicators. Washington, DC: World Bank; 2017. World Bank. World development indicators. Washington, DC: World Bank; 2017.
92.
go back to reference Tomlinson M, Solomon W, Singh Y, Doherty T, Chopra M, Ijumba P, Tsai AC, Jackson D. The use of mobile phones as a data collection tool: a report from a household survey in South Africa. BMC Med Inform Decis Mak. 2009;9(1):51.PubMedPubMedCentralCrossRef Tomlinson M, Solomon W, Singh Y, Doherty T, Chopra M, Ijumba P, Tsai AC, Jackson D. The use of mobile phones as a data collection tool: a report from a household survey in South Africa. BMC Med Inform Decis Mak. 2009;9(1):51.PubMedPubMedCentralCrossRef
93.
go back to reference Soti DO, Kinoti SN, Omar AH, Logedi J, Mwendwa TK, Hirji Z, Ferro S. Feasibility of an innovative electronic mobile system to assist health workers to collect accurate, complete and timely data in a malaria control programme in a remote setting in Kenya. Malar J. 2015;14:430.PubMedPubMedCentralCrossRef Soti DO, Kinoti SN, Omar AH, Logedi J, Mwendwa TK, Hirji Z, Ferro S. Feasibility of an innovative electronic mobile system to assist health workers to collect accurate, complete and timely data in a malaria control programme in a remote setting in Kenya. Malar J. 2015;14:430.PubMedPubMedCentralCrossRef
94.
go back to reference African Development Bank Group. Innovative e-Health solutions in Africa award. Abidjan: African Development Bank; 2014. African Development Bank Group. Innovative e-Health solutions in Africa award. Abidjan: African Development Bank; 2014.
96.
go back to reference Bor J, Fox MP, Rosen S, Venkataramani A, Tanser F, Pillay D, Bärnighausen T. Treatment eligibility and retention in clinical HIV care: a regression discontinuity study in South Africa. PLoS Med. 2017;14(11):e1002463.PubMedPubMedCentralCrossRef Bor J, Fox MP, Rosen S, Venkataramani A, Tanser F, Pillay D, Bärnighausen T. Treatment eligibility and retention in clinical HIV care: a regression discontinuity study in South Africa. PLoS Med. 2017;14(11):e1002463.PubMedPubMedCentralCrossRef
97.
go back to reference Brennan AT, Bor J, Davies MA, Wandeler G, Prozesky H, Fatti G, Wood R, Stinson K, Tanser F, Bärnighausen T, et al. Drug side effects and retention on HIV treatment: a regression discontinuity study of tenofovir implementation in South Africa and Zambia. Am J Epidemiol. 2018;187(9):1990-2001. Brennan AT, Bor J, Davies MA, Wandeler G, Prozesky H, Fatti G, Wood R, Stinson K, Tanser F, Bärnighausen T, et al. Drug side effects and retention on HIV treatment: a regression discontinuity study of tenofovir implementation in South Africa and Zambia. Am J Epidemiol. 2018;187(9):1990-2001.
98.
go back to reference Tatah L, Delbiso TD, Rodriguez-Llanes JM, Gil Cuesta J, Guha-Sapir D. Impact of refugees on local health systems: a difference-in-differences analysis in Cameroon. PLoS One. 2016;11(12):e0168820.PubMedPubMedCentralCrossRef Tatah L, Delbiso TD, Rodriguez-Llanes JM, Gil Cuesta J, Guha-Sapir D. Impact of refugees on local health systems: a difference-in-differences analysis in Cameroon. PLoS One. 2016;11(12):e0168820.PubMedPubMedCentralCrossRef
99.
go back to reference McGovern ME, Herbst K, Tanser F, Mutevedzi T, Canning D, Gareta D, Pillay D, Bärnighausen T. Do gifts increase consent to home-based HIV testing? A difference-in-differences study in rural KwaZulu-Natal, South Africa. Int J Epidemiol. 2016;45(6):2100–9.PubMedPubMedCentral McGovern ME, Herbst K, Tanser F, Mutevedzi T, Canning D, Gareta D, Pillay D, Bärnighausen T. Do gifts increase consent to home-based HIV testing? A difference-in-differences study in rural KwaZulu-Natal, South Africa. Int J Epidemiol. 2016;45(6):2100–9.PubMedPubMedCentral
100.
go back to reference Bärnighausen T, Rottingen JA, Rockers P, Shemilt I, Tugwell P. Quasi-experimental study designs series-paper 1: introduction: two historical lineages. J Clin Epidemiol. 2017;89:4–11.PubMedCrossRef Bärnighausen T, Rottingen JA, Rockers P, Shemilt I, Tugwell P. Quasi-experimental study designs series-paper 1: introduction: two historical lineages. J Clin Epidemiol. 2017;89:4–11.PubMedCrossRef
101.
go back to reference Gertler PJ, Martinez S, Premand P, Rawlings LB, Vermeersch C. Impact evaluation in practice. Washington, DC: The World Bank; 2011. Gertler PJ, Martinez S, Premand P, Rawlings LB, Vermeersch C. Impact evaluation in practice. Washington, DC: The World Bank; 2011.
102.
go back to reference European Commission. Social policy experiments in the European Union: examples in member states. Brussels: European Commission; 2011. European Commission. Social policy experiments in the European Union: examples in member states. Brussels: European Commission; 2011.
104.
go back to reference WHO TDR. Progress report on the TDR postgraduate training scheme during the period May 2015 - May 2017. Geneva: WHO TDR. p. 2017. WHO TDR. Progress report on the TDR postgraduate training scheme during the period May 2015 - May 2017. Geneva: WHO TDR. p. 2017.
105.
go back to reference McKee M, Stuckler D, Basu S. Where there is no health research: what can be done to fill the global gaps in health research. PLoS Med. 2012;9(4):e1001209.PubMedPubMedCentralCrossRef McKee M, Stuckler D, Basu S. Where there is no health research: what can be done to fill the global gaps in health research. PLoS Med. 2012;9(4):e1001209.PubMedPubMedCentralCrossRef
106.
go back to reference Schwartz JI, Dunkle A, Akiteng AR, Birabwa-Male D, Kagimu R, Mondo CK, Mutungi G, Rabin TL, Skonieczny M, Sykes J, et al. Towards reframing health service delivery in Uganda: the Uganda initiative for integrated management of non-communicable diseases. Glob Health Action. 2015;8:26537.PubMedCrossRef Schwartz JI, Dunkle A, Akiteng AR, Birabwa-Male D, Kagimu R, Mondo CK, Mutungi G, Rabin TL, Skonieczny M, Sykes J, et al. Towards reframing health service delivery in Uganda: the Uganda initiative for integrated management of non-communicable diseases. Glob Health Action. 2015;8:26537.PubMedCrossRef
107.
go back to reference Chanda-Kapata P, Ngosa W, Hamainza B, Kapiriri L. Health research priority setting in Zambia: a stock taking of approaches conducted from 1998 to 2015. Health Res Policy Syst. 2016;14(1):72.PubMedPubMedCentralCrossRef Chanda-Kapata P, Ngosa W, Hamainza B, Kapiriri L. Health research priority setting in Zambia: a stock taking of approaches conducted from 1998 to 2015. Health Res Policy Syst. 2016;14(1):72.PubMedPubMedCentralCrossRef
110.
go back to reference Cowan FM, Delany-Moretlwe S, Sanders EJ, Mugo NR, Guedou FA, Alary M, Behanzin L, Mugurungi O, Bekker LG. PrEP implementation research in Africa: what is new? J Int AIDS Soc. 2016;19(7(Suppl 6)):21101.PubMedPubMedCentral Cowan FM, Delany-Moretlwe S, Sanders EJ, Mugo NR, Guedou FA, Alary M, Behanzin L, Mugurungi O, Bekker LG. PrEP implementation research in Africa: what is new? J Int AIDS Soc. 2016;19(7(Suppl 6)):21101.PubMedPubMedCentral
111.
go back to reference Geldsetzer P, Bärnighausen T. Late-stage research for diabetes and related NCDs receives little funding: evidence from the NIH RePORTER tool. Lancet Diabetes Endocrinol. 2017;5(2):91–2.PubMedCrossRef Geldsetzer P, Bärnighausen T. Late-stage research for diabetes and related NCDs receives little funding: evidence from the NIH RePORTER tool. Lancet Diabetes Endocrinol. 2017;5(2):91–2.PubMedCrossRef
112.
go back to reference Jain A, Agarwal R, Chawla D, Paul V, Deorari A. Tele-education vs classroom training of neonatal resuscitation: a randomized trial. J Perinatol: official journal of the California Perinatal Association. 2010;30(12):773–9.CrossRef Jain A, Agarwal R, Chawla D, Paul V, Deorari A. Tele-education vs classroom training of neonatal resuscitation: a randomized trial. J Perinatol: official journal of the California Perinatal Association. 2010;30(12):773–9.CrossRef
113.
go back to reference Patel SN, Martinez-Castellanos MA, Berrones-Medina D, Swan R, Ryan MC, Jonas KE, Ostmo S, Campbell JP, Chiang MF, Chan RVP. Assessment of a tele-education system to enhance retinopathy of prematurity training by international ophthalmologists-in-training in Mexico. Ophthalmology. 2017;124(7):953–61.PubMedCrossRef Patel SN, Martinez-Castellanos MA, Berrones-Medina D, Swan R, Ryan MC, Jonas KE, Ostmo S, Campbell JP, Chiang MF, Chan RVP. Assessment of a tele-education system to enhance retinopathy of prematurity training by international ophthalmologists-in-training in Mexico. Ophthalmology. 2017;124(7):953–61.PubMedCrossRef
114.
go back to reference Joshi A, Novaes MA, Iyengar S, Machiavelli JL, Zhang J, Vogler R, Hsu CE. Evaluation of a tele-education programme in Brazil. J Telemed Telecare. 2011;17(7):341–5.PubMedCrossRef Joshi A, Novaes MA, Iyengar S, Machiavelli JL, Zhang J, Vogler R, Hsu CE. Evaluation of a tele-education programme in Brazil. J Telemed Telecare. 2011;17(7):341–5.PubMedCrossRef
115.
go back to reference Pradeep PV, Mishra A, Mohanty BN, Mohapatra KC, Agarwal G, Mishra SK. Reinforcement of endocrine surgery training: impact of telemedicine technology in a developing country context. World J Surg. 2007;31(8):1665–71.PubMedCrossRef Pradeep PV, Mishra A, Mohanty BN, Mohapatra KC, Agarwal G, Mishra SK. Reinforcement of endocrine surgery training: impact of telemedicine technology in a developing country context. World J Surg. 2007;31(8):1665–71.PubMedCrossRef
116.
go back to reference Chao LW, Cestari TF, Bakos L, Oliveira MR, Miot HA, Zampese M, Andrade CB, Bohm GM. Evaluation of an internet-based teledermatology system. J Telemed Telecare. 2003;9(Suppl 1):S9–12.PubMedCrossRef Chao LW, Cestari TF, Bakos L, Oliveira MR, Miot HA, Zampese M, Andrade CB, Bohm GM. Evaluation of an internet-based teledermatology system. J Telemed Telecare. 2003;9(Suppl 1):S9–12.PubMedCrossRef
117.
go back to reference Moughrabieh A, Weinert C. Rapid deployment of international tele-intensive care unit services in war-torn Syria. Ann Am Thorac Soc. 2016;13(2):165–72.PubMedPubMedCentralCrossRef Moughrabieh A, Weinert C. Rapid deployment of international tele-intensive care unit services in war-torn Syria. Ann Am Thorac Soc. 2016;13(2):165–72.PubMedPubMedCentralCrossRef
118.
go back to reference Fairall L, Bachmann MO, Lombard C, Timmerman V, Uebel K, Zwarenstein M, Boulle A, Georgeu D, Colvin CJ, Lewin S, et al. Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial. Lancet. 2012;380(9845):889–98.PubMedPubMedCentralCrossRef Fairall L, Bachmann MO, Lombard C, Timmerman V, Uebel K, Zwarenstein M, Boulle A, Georgeu D, Colvin CJ, Lewin S, et al. Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial. Lancet. 2012;380(9845):889–98.PubMedPubMedCentralCrossRef
119.
go back to reference Maulik PK, Kallakuri S, Devarapalli S, Vadlamani VK, Jha V, Patel A. Increasing use of mental health services in remote areas using mobile technology: a pre-post evaluation of the SMART mental health project in rural India. J Glob Health. 2017;7(1):010408.PubMedPubMedCentralCrossRef Maulik PK, Kallakuri S, Devarapalli S, Vadlamani VK, Jha V, Patel A. Increasing use of mental health services in remote areas using mobile technology: a pre-post evaluation of the SMART mental health project in rural India. J Glob Health. 2017;7(1):010408.PubMedPubMedCentralCrossRef
120.
go back to reference Ogedegbe G, Plange-Rhule J, Gyamfi J, Chaplin W, Ntim M, Apusiga K, Khurshid K, Cooper R. A cluster-randomized trial of task shifting and blood pressure control in Ghana: study protocol. Implement Sci. 2014;9:73.PubMedPubMedCentralCrossRef Ogedegbe G, Plange-Rhule J, Gyamfi J, Chaplin W, Ntim M, Apusiga K, Khurshid K, Cooper R. A cluster-randomized trial of task shifting and blood pressure control in Ghana: study protocol. Implement Sci. 2014;9:73.PubMedPubMedCentralCrossRef
121.
go back to reference Ahmed S, Kim MH, Dave AC, Sabelli R, Kanjelo K, Preidis GA, Giordano TP, Chiao E, Hosseinipour M, Kazembe PN, et al. Improved identification and enrolment into care of HIV-exposed and -infected infants and children following a community health worker intervention in Lilongwe, Malawi. J Int AIDS Soc. 2015;18:19305.PubMedPubMedCentralCrossRef Ahmed S, Kim MH, Dave AC, Sabelli R, Kanjelo K, Preidis GA, Giordano TP, Chiao E, Hosseinipour M, Kazembe PN, et al. Improved identification and enrolment into care of HIV-exposed and -infected infants and children following a community health worker intervention in Lilongwe, Malawi. J Int AIDS Soc. 2015;18:19305.PubMedPubMedCentralCrossRef
122.
go back to reference Geldsetzer P, Francis JM, Ulenga N, Sando D, Lema IA, Mboggo E, Vaikath M, Koda H, Lwezaula S, Hu J, et al. The impact of community health worker-led home delivery of antiretroviral therapy on virological suppression: a non-inferiority cluster-randomized health systems trial in Dar es Salaam, Tanzania. BMC Health Serv Res. 2017;17(1):160.PubMedPubMedCentralCrossRef Geldsetzer P, Francis JM, Ulenga N, Sando D, Lema IA, Mboggo E, Vaikath M, Koda H, Lwezaula S, Hu J, et al. The impact of community health worker-led home delivery of antiretroviral therapy on virological suppression: a non-inferiority cluster-randomized health systems trial in Dar es Salaam, Tanzania. BMC Health Serv Res. 2017;17(1):160.PubMedPubMedCentralCrossRef
123.
go back to reference Jennings L, Yebadokpo AS, Affo J, Agbogbe M, Tankoano A. Task shifting in maternal and newborn care: a non-inferiority study examining delegation of antenatal counseling to lay nurse aides supported by job aids in Benin. Implement Sci. 2011;6:2.PubMedPubMedCentralCrossRef Jennings L, Yebadokpo AS, Affo J, Agbogbe M, Tankoano A. Task shifting in maternal and newborn care: a non-inferiority study examining delegation of antenatal counseling to lay nurse aides supported by job aids in Benin. Implement Sci. 2011;6:2.PubMedPubMedCentralCrossRef
124.
go back to reference MacPherson P, Lalloo DG, Webb EL, Maheswaran H, Choko AT, Makombe SD, Butterworth AE, van Oosterhout JJ, Desmond N, Thindwa D, et al. Effect of optional home initiation of HIV care following HIV self-testing on antiretroviral therapy initiation among adults in Malawi: a randomized clinical trial. J Am Med Assoc. 2014;312(4):372–9. MacPherson P, Lalloo DG, Webb EL, Maheswaran H, Choko AT, Makombe SD, Butterworth AE, van Oosterhout JJ, Desmond N, Thindwa D, et al. Effect of optional home initiation of HIV care following HIV self-testing on antiretroviral therapy initiation among adults in Malawi: a randomized clinical trial. J Am Med Assoc. 2014;312(4):372–9.
125.
go back to reference Ortblad K, Kibuuka Musoke D, Ngabirano T, Nakitende A, Magoola J, Kayiira P, Taasi G, Barresi LG, Haberer JE, McConnell MA, et al. Direct provision versus facility collection of HIV self-tests among female sex workers in Uganda: a cluster-randomized controlled health systems trial. PLoS Med. 2017;14(11):e1002458.PubMedPubMedCentralCrossRef Ortblad K, Kibuuka Musoke D, Ngabirano T, Nakitende A, Magoola J, Kayiira P, Taasi G, Barresi LG, Haberer JE, McConnell MA, et al. Direct provision versus facility collection of HIV self-tests among female sex workers in Uganda: a cluster-randomized controlled health systems trial. PLoS Med. 2017;14(11):e1002458.PubMedPubMedCentralCrossRef
126.
go back to reference Chanda MM, Ortblad KF, Mwale M, Chongo S, Kanchele C, Kamungoma N, Fullem A, Dunn C, Barresi LG, Harling G, et al. HIV self-testing among female sex workers in Zambia: a cluster randomized controlled trial. PLoS Med. 2017;14(11):e1002442.PubMedPubMedCentralCrossRef Chanda MM, Ortblad KF, Mwale M, Chongo S, Kanchele C, Kamungoma N, Fullem A, Dunn C, Barresi LG, Harling G, et al. HIV self-testing among female sex workers in Zambia: a cluster randomized controlled trial. PLoS Med. 2017;14(11):e1002442.PubMedPubMedCentralCrossRef
127.
go back to reference Asiimwe S, Oloya J, Song X, Whalen CC. Accuracy of un-supervised versus provider-supervised self-administered HIV testing in Uganda: a randomized implementation trial. AIDS Behav. 2014;18(12):2477–84.PubMedPubMedCentralCrossRef Asiimwe S, Oloya J, Song X, Whalen CC. Accuracy of un-supervised versus provider-supervised self-administered HIV testing in Uganda: a randomized implementation trial. AIDS Behav. 2014;18(12):2477–84.PubMedPubMedCentralCrossRef
128.
go back to reference Jeronimo J, Bansil P, Lim J, Peck R, Paul P, Amador JJ, Mirembe F, Byamugisha J, Poli UR, Satyanarayana L, et al. A multicountry evaluation of careHPV testing, visual inspection with acetic acid, and papanicolaou testing for the detection of cervical cancer. Int J Gynecol Cancer. 2014;24(3):576–85.PubMedPubMedCentralCrossRef Jeronimo J, Bansil P, Lim J, Peck R, Paul P, Amador JJ, Mirembe F, Byamugisha J, Poli UR, Satyanarayana L, et al. A multicountry evaluation of careHPV testing, visual inspection with acetic acid, and papanicolaou testing for the detection of cervical cancer. Int J Gynecol Cancer. 2014;24(3):576–85.PubMedPubMedCentralCrossRef
129.
go back to reference Awah PK, Boock AU, Mou F, Koin JT, Anye EM, Noumen D, Nichter M. Developing a Buruli ulcer community of practice in Bankim, Cameroon: a model for Buruli ulcer outreach in Africa. PLoS Negl Trop Dis. 2018;12(3):e0006238.PubMedPubMedCentralCrossRef Awah PK, Boock AU, Mou F, Koin JT, Anye EM, Noumen D, Nichter M. Developing a Buruli ulcer community of practice in Bankim, Cameroon: a model for Buruli ulcer outreach in Africa. PLoS Negl Trop Dis. 2018;12(3):e0006238.PubMedPubMedCentralCrossRef
130.
go back to reference Rocha R, Soares RR. Evaluating the impact of community-based health interventions: evidence from Brazil’s family health program. Health Econ. 2010;19(Suppl):126–58.PubMedCrossRef Rocha R, Soares RR. Evaluating the impact of community-based health interventions: evidence from Brazil’s family health program. Health Econ. 2010;19(Suppl):126–58.PubMedCrossRef
131.
go back to reference Odeny TA, Bukusi EA, Cohen CR, Yuhas K, Camlin CS, McClelland RS. Texting improves testing: a randomized trial of two-way SMS to increase postpartum prevention of mother-to-child transmission retention and infant HIV testing. AIDS. 2014;28(15):2307–12. Odeny TA, Bukusi EA, Cohen CR, Yuhas K, Camlin CS, McClelland RS. Texting improves testing: a randomized trial of two-way SMS to increase postpartum prevention of mother-to-child transmission retention and infant HIV testing. AIDS. 2014;28(15):2307–12.
132.
go back to reference Piette JD, Datwani H, Gaudioso S, Foster SM, Westphal J, Perry W, Rodriguez-Saldana J, Mendoza-Avelares MO, Marinec N. Hypertension management using mobile technology and home blood pressure monitoring: results of a randomized trial in two low/middle-income countries. Telemed J E Health. 2012;18(8):613–20.PubMedPubMedCentralCrossRef Piette JD, Datwani H, Gaudioso S, Foster SM, Westphal J, Perry W, Rodriguez-Saldana J, Mendoza-Avelares MO, Marinec N. Hypertension management using mobile technology and home blood pressure monitoring: results of a randomized trial in two low/middle-income countries. Telemed J E Health. 2012;18(8):613–20.PubMedPubMedCentralCrossRef
133.
go back to reference Bobrow K, Farmer AJ, Springer D, Shanyinde M, Yu LM, Brennan T, Rayner B, Namane M, Steyn K, Tarassenko L, et al. Mobile phone text messages to support treatment adherence in adults with high blood pressure (SMS-Text Adherence Support [StAR]): a single-blind, randomized trial. Circulation. 2016;133(6):592–600.PubMedPubMedCentral Bobrow K, Farmer AJ, Springer D, Shanyinde M, Yu LM, Brennan T, Rayner B, Namane M, Steyn K, Tarassenko L, et al. Mobile phone text messages to support treatment adherence in adults with high blood pressure (SMS-Text Adherence Support [StAR]): a single-blind, randomized trial. Circulation. 2016;133(6):592–600.PubMedPubMedCentral
134.
go back to reference Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH, Jack W, Habyarimana J, Sadatsafavi M, Najafzadeh M, et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet. 2010;376(9755):1838–45.PubMedCrossRef Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH, Jack W, Habyarimana J, Sadatsafavi M, Najafzadeh M, et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet. 2010;376(9755):1838–45.PubMedCrossRef
135.
go back to reference Jani IV, Meggi B, Vubil A, Sitoe NE, Bhatt N, Tobaiwa O, Quevedo JI, Loquiha O, Lehe JD, Vojnov L, et al. Evaluation of the whole-blood Alere Q NAT point-of-care RNA assay for HIV-1 viral load monitoring in a primary health care setting in Mozambique. J Clin Microbiol. 2016;54(8):2104–8.PubMedPubMedCentralCrossRef Jani IV, Meggi B, Vubil A, Sitoe NE, Bhatt N, Tobaiwa O, Quevedo JI, Loquiha O, Lehe JD, Vojnov L, et al. Evaluation of the whole-blood Alere Q NAT point-of-care RNA assay for HIV-1 viral load monitoring in a primary health care setting in Mozambique. J Clin Microbiol. 2016;54(8):2104–8.PubMedPubMedCentralCrossRef
136.
go back to reference Mtapuri-Zinyowera S, Chideme M, Mangwanya D, Mugurungi O, Gudukeya S, Hatzold K, Mangwiro A, Bhattacharya G, Lehe J, Peter T. Evaluation of the PIMA point-of-care CD4 analyzer in VCT clinics in Zimbabwe. J Acquir Immune Defic Syndr. 2010;55(1):1–7.PubMedCrossRef Mtapuri-Zinyowera S, Chideme M, Mangwanya D, Mugurungi O, Gudukeya S, Hatzold K, Mangwiro A, Bhattacharya G, Lehe J, Peter T. Evaluation of the PIMA point-of-care CD4 analyzer in VCT clinics in Zimbabwe. J Acquir Immune Defic Syndr. 2010;55(1):1–7.PubMedCrossRef
137.
go back to reference Jani IV, Sitoe NE, Alfai ER, Chongo PL, Quevedo JI, Rocha BM, Lehe JD, Peter TF. Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort study. Lancet. 2011;378(9802):1572–9.PubMedCrossRef Jani IV, Sitoe NE, Alfai ER, Chongo PL, Quevedo JI, Rocha BM, Lehe JD, Peter TF. Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort study. Lancet. 2011;378(9802):1572–9.PubMedCrossRef
138.
go back to reference Theron G, Zijenah L, Chanda D, Clowes P, Rachow A, Lesosky M, Bara W, Mungofa S, Pai M, Hoelscher M, et al. Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial. Lancet. 2014;383(9915):424–35.PubMedCrossRef Theron G, Zijenah L, Chanda D, Clowes P, Rachow A, Lesosky M, Bara W, Mungofa S, Pai M, Hoelscher M, et al. Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial. Lancet. 2014;383(9915):424–35.PubMedCrossRef
139.
go back to reference Somashekhar S, Vijay R, Ananthasivan R, Prasanna G. Noninvasive and low-cost technique for early detection of clinically relevant breast lesions using a handheld point-of-care medical device (iBreastExam): prospective three-arm triple-blinded comparative study. Indian J Gynecol Oncol. 2016;13:26.CrossRef Somashekhar S, Vijay R, Ananthasivan R, Prasanna G. Noninvasive and low-cost technique for early detection of clinically relevant breast lesions using a handheld point-of-care medical device (iBreastExam): prospective three-arm triple-blinded comparative study. Indian J Gynecol Oncol. 2016;13:26.CrossRef
140.
go back to reference Dahinten AP, Dow DE, Cunningham CK, Msuya LJ, Mmbaga BT, Malkin RA. Providing safe and effective preventative antiretroviral prophylaxis to HIV-exposed newborns via a novel drug delivery system in Tanzania. Pediatr Infect Dis J. 2016;35(9):987–91.PubMedPubMedCentralCrossRef Dahinten AP, Dow DE, Cunningham CK, Msuya LJ, Mmbaga BT, Malkin RA. Providing safe and effective preventative antiretroviral prophylaxis to HIV-exposed newborns via a novel drug delivery system in Tanzania. Pediatr Infect Dis J. 2016;35(9):987–91.PubMedPubMedCentralCrossRef
141.
go back to reference Rutta E, Kibassa B, McKinnon B, Liana J, Mbwasi R, Mlaki W, Embrey M, Gabra M, Shekalaghe E, Kimatta S, et al. Increasing access to subsidized artemisinin-based combination therapy through accredited drug dispensing outlets in Tanzania. Health Res Policy Syst. 2011;9:22.PubMedPubMedCentralCrossRef Rutta E, Kibassa B, McKinnon B, Liana J, Mbwasi R, Mlaki W, Embrey M, Gabra M, Shekalaghe E, Kimatta S, et al. Increasing access to subsidized artemisinin-based combination therapy through accredited drug dispensing outlets in Tanzania. Health Res Policy Syst. 2011;9:22.PubMedPubMedCentralCrossRef
142.
go back to reference Berry J, Berry S, Ramchandani R. Colalife operational trial Zambia (COTZ) -- improving use, access, availability and awareness of ORS and zinc for the treatment of diarrhoea in the home: endline survey report. Lusaka: RuralNet Associates Ltd; 2014. Berry J, Berry S, Ramchandani R. Colalife operational trial Zambia (COTZ) -- improving use, access, availability and awareness of ORS and zinc for the treatment of diarrhoea in the home: endline survey report. Lusaka: RuralNet Associates Ltd; 2014.
143.
go back to reference Molemodile S, Wotogbe M, Abimbola S. Evaluation of a pilot intervention to redesign the decentralised vaccine supply chain system in Nigeria. Glob Public Health. 2017;12(5):601–16.PubMedCrossRef Molemodile S, Wotogbe M, Abimbola S. Evaluation of a pilot intervention to redesign the decentralised vaccine supply chain system in Nigeria. Glob Public Health. 2017;12(5):601–16.PubMedCrossRef
144.
go back to reference Mehta KM, Rerolle F, Rammohan SV, Albohm DC, Muwowo G, Moseson H, Sept L, Lee HL, Bendavid E. Systematic motorcycle management and health care delivery: a field trial. Am J Public Health. 2016;106(1):87–94.PubMedPubMedCentralCrossRef Mehta KM, Rerolle F, Rammohan SV, Albohm DC, Muwowo G, Moseson H, Sept L, Lee HL, Bendavid E. Systematic motorcycle management and health care delivery: a field trial. Am J Public Health. 2016;106(1):87–94.PubMedPubMedCentralCrossRef
Metadata
Title
Implementation science in resource-poor countries and communities
Authors
H. Manisha Yapa
Till Bärnighausen
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Implementation Science / Issue 1/2018
Electronic ISSN: 1748-5908
DOI
https://doi.org/10.1186/s13012-018-0847-1

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