Skip to main content
Top
Published in: Implementation Science 1/2017

Open Access 01-12-2017 | Research

Process evaluation of the data-driven quality improvement in primary care (DQIP) trial: active and less active ingredients of a multi-component complex intervention to reduce high-risk primary care prescribing

Authors: Aileen Grant, Tobias Dreischulte, Bruce Guthrie

Published in: Implementation Science | Issue 1/2017

Login to get access

Abstract

Background

Two to 4% of emergency hospital admissions are caused by preventable adverse drug events. The estimated costs of such avoidable admissions in England were £530 million in 2015. The data-driven quality improvement in primary care (DQIP) intervention was designed to prompt review of patients vulnerable from currently prescribed non-steroidal anti-inflammatory drugs (NSAIDs) and anti-platelets and was found to be effective at reducing this prescribing. A process evaluation was conducted parallel to the trial, and this paper reports the analysis which aimed to explore response to the intervention delivered to clusters in relation to participants’ perceptions about which intervention elements were active in changing their practice.

Methods

Data generation was by in-depth interview with key staff exploring participant’s perceptions of the intervention components. Analysis was iterative using the framework technique and drawing on normalisation process theory.

Results

All the primary components of the intervention were perceived as active, but at different stages of implementation: financial incentives primarily supported recruitment; education motivated the GPs to initiate implementation; the informatics tool facilitated sustained implementation. Participants perceived the primary components as interdependent. Intervention subcomponents also varied in whether and when they were active. For example, run charts providing feedback of change in prescribing over time were ignored in the informatics tool, but were motivating in some practices in the regular e-mailed newsletter. The high-risk NSAID and anti-platelet prescribing targeted was accepted as important by all interviewees, and this shared understanding was a key wider context underlying intervention effectiveness.

Conclusions

This was a novel use of process evaluation data which examined whether and how the individual intervention components were effective from the perspective of the professionals delivering changed care to patients. These findings are important for reproducibility and roll-out of the intervention.

Trial registration

ClinicalTrials.gov, NCT01425502.
Appendix
Available only for authorised users
Literature
1.
go back to reference Howard R, Avery A, Bissell P. Causes of preventable drug-related hospital admissions: a qualitative study. Qual Saf Health Care. 2008;17(2):109–16.CrossRefPubMed Howard R, Avery A, Bissell P. Causes of preventable drug-related hospital admissions: a qualitative study. Qual Saf Health Care. 2008;17(2):109–16.CrossRefPubMed
2.
go back to reference Hakkarainen KM, Hedna K, Petzold M, Hagg S. Percentage of patients with preventable adverse drug reactions and preventability of adverse drug reactions—a meta-analysis. PLoS One. 2012;7(3):e33236.CrossRefPubMedPubMedCentral Hakkarainen KM, Hedna K, Petzold M, Hagg S. Percentage of patients with preventable adverse drug reactions and preventability of adverse drug reactions—a meta-analysis. PLoS One. 2012;7(3):e33236.CrossRefPubMedPubMedCentral
5.
go back to reference Howard RL, Avery A, Slavenburg S, Royal S, Pipe G, Lucassen P, Pirohamed M. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol. 2006;63:136–47.CrossRefPubMedPubMedCentral Howard RL, Avery A, Slavenburg S, Royal S, Pipe G, Lucassen P, Pirohamed M. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol. 2006;63:136–47.CrossRefPubMedPubMedCentral
6.
go back to reference Budnitz DS, Lovegrove MC, Shehab N, Richards CL. Emergency hospitalisation for adverse drug events in older Americans. N Engl J Med. 2011;365(21):2002–12.CrossRefPubMed Budnitz DS, Lovegrove MC, Shehab N, Richards CL. Emergency hospitalisation for adverse drug events in older Americans. N Engl J Med. 2011;365(21):2002–12.CrossRefPubMed
7.
go back to reference Leendertse AJ, Egberts ACG, Stoker LJ, van den Bent PM. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168(17):1890–6.PubMed Leendertse AJ, Egberts ACG, Stoker LJ, van den Bent PM. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168(17):1890–6.PubMed
8.
go back to reference Guthrie B, McCowan C, Davey P, Simpson CR, Dreischulte T, Barnett K. High risk prescribing in primary care patients particularly vulnerable to adverse drug events: cross sectional population database analysis in Scottish general practice. Br Med J. 2011;342:d3514.CrossRef Guthrie B, McCowan C, Davey P, Simpson CR, Dreischulte T, Barnett K. High risk prescribing in primary care patients particularly vulnerable to adverse drug events: cross sectional population database analysis in Scottish general practice. Br Med J. 2011;342:d3514.CrossRef
9.
go back to reference Dreischulte T, Grant A, Donnan P, McCowan C, Davey P, Petrie D, Treweek S, Guthrie B. A cluster randomised stepped wedge trial to evaluate the effectiveness of a multifaceted information technology-based intervention in reducing high-risk prescribing of non-steroidal anti-inflammatory drugs and antiplatelets in primary care: the DQIP study protocol. Implement Sci. 2012;7:24.CrossRefPubMedPubMedCentral Dreischulte T, Grant A, Donnan P, McCowan C, Davey P, Petrie D, Treweek S, Guthrie B. A cluster randomised stepped wedge trial to evaluate the effectiveness of a multifaceted information technology-based intervention in reducing high-risk prescribing of non-steroidal anti-inflammatory drugs and antiplatelets in primary care: the DQIP study protocol. Implement Sci. 2012;7:24.CrossRefPubMedPubMedCentral
12.
go back to reference Dreischulte T, Donnan P, Grant A, Hapca A, McCowan C, Guthrie B. Safer prescribing—a trial of education, informatics and financial incentives. New England J Med. 2016;374:1053–64.CrossRef Dreischulte T, Donnan P, Grant A, Hapca A, McCowan C, Guthrie B. Safer prescribing—a trial of education, informatics and financial incentives. New England J Med. 2016;374:1053–64.CrossRef
13.
go back to reference Dopson S, Locock L, Chambers D, Gabbay J. Implementation of evidence-based medicine: evaluation of the promoting action of clinical effectiveness programme. J Health Serv Res Policy. 2001;6:23–31.CrossRefPubMed Dopson S, Locock L, Chambers D, Gabbay J. Implementation of evidence-based medicine: evaluation of the promoting action of clinical effectiveness programme. J Health Serv Res Policy. 2001;6:23–31.CrossRefPubMed
14.
go back to reference Glasziou P, Meats E, Heneghan C, Shepperd S. What is missing from descriptions of treatment in trials and reviews? Br Med J. 2008;336(7659):1472–4.CrossRef Glasziou P, Meats E, Heneghan C, Shepperd S. What is missing from descriptions of treatment in trials and reviews? Br Med J. 2008;336(7659):1472–4.CrossRef
15.
go back to reference Hoffmann TC, Glasziou PP, Boutron I, Milne R, Perera R, Moher D, Altman DG, Barbour V, Macdonald H, Johnston M, Lamb SE, Dixon-Woods M, McCulloch P, Wyatt JC, Chan A, Michie S. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. Br Med J. 2014;348:g1687.CrossRef Hoffmann TC, Glasziou PP, Boutron I, Milne R, Perera R, Moher D, Altman DG, Barbour V, Macdonald H, Johnston M, Lamb SE, Dixon-Woods M, McCulloch P, Wyatt JC, Chan A, Michie S. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. Br Med J. 2014;348:g1687.CrossRef
16.
go back to reference Medical Research Council. Developing and evaluating complex interventions: new guidance. 2008. Medical Research Council. Developing and evaluating complex interventions: new guidance. 2008.
17.
go back to reference Medical Research Council. Process evaluation of complex interventions: UK Medical Research Council (MRC) guidance. 2015. Medical Research Council. Process evaluation of complex interventions: UK Medical Research Council (MRC) guidance. 2015.
18.
go back to reference Grant A, Treweek S, Dreischulte T, Foy R, Guthrie B. Process evaluations for cluster-randomised trials of complex interventions: a proposed framework for design and reporting. Trials. 2013;14(1):15.CrossRefPubMedPubMedCentral Grant A, Treweek S, Dreischulte T, Foy R, Guthrie B. Process evaluations for cluster-randomised trials of complex interventions: a proposed framework for design and reporting. Trials. 2013;14(1):15.CrossRefPubMedPubMedCentral
19.
go back to reference May C, Finch T. Implementing, embedding, and integrating practices: an outline of normalisation process theory. Sociology. 2009;43:535.CrossRef May C, Finch T. Implementing, embedding, and integrating practices: an outline of normalisation process theory. Sociology. 2009;43:535.CrossRef
20.
go back to reference Grant A, Dreischulte T, Treweek S, Guthrie B. Study protocol of a mixed-methods evaluation of a cluster randomised trial to improve the safety of NSAID and antiplatelet prescribing: data-driven quality improvement in primary care. Trials. 2012;13:154.CrossRefPubMedPubMedCentral Grant A, Dreischulte T, Treweek S, Guthrie B. Study protocol of a mixed-methods evaluation of a cluster randomised trial to improve the safety of NSAID and antiplatelet prescribing: data-driven quality improvement in primary care. Trials. 2012;13:154.CrossRefPubMedPubMedCentral
21.
go back to reference Palinkas LA, Horwitz SM, Green CA, Wisdom JP, Duan N, Hoagwood K. Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Administration Policy Mental Health Mental Health Serv Res. 2015;42(5):533–44.CrossRef Palinkas LA, Horwitz SM, Green CA, Wisdom JP, Duan N, Hoagwood K. Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Administration Policy Mental Health Mental Health Serv Res. 2015;42(5):533–44.CrossRef
22.
go back to reference Grant A, Sullivan F, Dowell J. An ethnographic exploration of influences on prescribing in general practice: why is there variation in prescribing practices? Implement Sci. 2013;8(1):72.CrossRefPubMedPubMedCentral Grant A, Sullivan F, Dowell J. An ethnographic exploration of influences on prescribing in general practice: why is there variation in prescribing practices? Implement Sci. 2013;8(1):72.CrossRefPubMedPubMedCentral
23.
go back to reference Glaser B, Strauss A. The discovery of grounded theory: strategies for qualitative research. Chicago: Aldine Publishing Co; 1967. Glaser B, Strauss A. The discovery of grounded theory: strategies for qualitative research. Chicago: Aldine Publishing Co; 1967.
24.
go back to reference Ritchie J, Spencer L, O’Connor W. Carrying out qualitative analysis. In: Ritchie J, Lewis J, editors. Qualitative research practice, a guide for social science students and researchers. London: Sage Publications Ltd; 2003. Ritchie J, Spencer L, O’Connor W. Carrying out qualitative analysis. In: Ritchie J, Lewis J, editors. Qualitative research practice, a guide for social science students and researchers. London: Sage Publications Ltd; 2003.
25.
go back to reference Ivers NM, Grimshaw JM, Jamtvedt G, Flottorp S, O’Brien MA, French SD, Young J, Odgaard-Jensen J. Growing literature, stagnant science? Systematic review, meta-regression and cumulative analysis of audit and feedback interventions in health care. J Gen Intern Med. 2014;29(11):1534–41.CrossRefPubMedPubMedCentral Ivers NM, Grimshaw JM, Jamtvedt G, Flottorp S, O’Brien MA, French SD, Young J, Odgaard-Jensen J. Growing literature, stagnant science? Systematic review, meta-regression and cumulative analysis of audit and feedback interventions in health care. J Gen Intern Med. 2014;29(11):1534–41.CrossRefPubMedPubMedCentral
26.
go back to reference Guthrie B, Kavanagh K, Robertson C, Barnett K, Treweek S, Petrie D, Ritchie L, Bennie M. Data feedback and behavioural change intervention to improve primary care prescribing safety (EFIPPS): multicentre, three arm, cluster randomised controlled trial. BMJ. 2016;354:i4079.CrossRefPubMedPubMedCentral Guthrie B, Kavanagh K, Robertson C, Barnett K, Treweek S, Petrie D, Ritchie L, Bennie M. Data feedback and behavioural change intervention to improve primary care prescribing safety (EFIPPS): multicentre, three arm, cluster randomised controlled trial. BMJ. 2016;354:i4079.CrossRefPubMedPubMedCentral
27.
go back to reference Avery AJ, Rodgers S, Cantrill JA, Armstrong S, Cresswell K, Eden M, Elliott RA, Howard R, Kendrick D, Morris CJ, Prescott RJ, Swanwick G, Franklin M, Putman K, Boyd M, Sheikh A. A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis. Lancet. 2012;379(9823):1310–9.CrossRefPubMed Avery AJ, Rodgers S, Cantrill JA, Armstrong S, Cresswell K, Eden M, Elliott RA, Howard R, Kendrick D, Morris CJ, Prescott RJ, Swanwick G, Franklin M, Putman K, Boyd M, Sheikh A. A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis. Lancet. 2012;379(9823):1310–9.CrossRefPubMed
28.
go back to reference Cresswell K, Sadler S, Rodgers S, Avery A, Cantrill J, Murray S, Sheikh A. An embedded longitudinal multi-faceted qualitative evaluation of a complex cluster randomized controlled trial aiming to reduce clinically important errors in medicines management in general practice. Trials. 2012;13(1):78.CrossRefPubMedPubMedCentral Cresswell K, Sadler S, Rodgers S, Avery A, Cantrill J, Murray S, Sheikh A. An embedded longitudinal multi-faceted qualitative evaluation of a complex cluster randomized controlled trial aiming to reduce clinically important errors in medicines management in general practice. Trials. 2012;13(1):78.CrossRefPubMedPubMedCentral
29.
go back to reference McCleary N, Duncan E, Stewart F, Francis J. Active ingredients are reported more often for pharmalogic than non-pharmalogic interventions: an illustrative review of reporting practices in titles and abstracts. Trials. 2013;14:146.CrossRefPubMedPubMedCentral McCleary N, Duncan E, Stewart F, Francis J. Active ingredients are reported more often for pharmalogic than non-pharmalogic interventions: an illustrative review of reporting practices in titles and abstracts. Trials. 2013;14:146.CrossRefPubMedPubMedCentral
Metadata
Title
Process evaluation of the data-driven quality improvement in primary care (DQIP) trial: active and less active ingredients of a multi-component complex intervention to reduce high-risk primary care prescribing
Authors
Aileen Grant
Tobias Dreischulte
Bruce Guthrie
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Implementation Science / Issue 1/2017
Electronic ISSN: 1748-5908
DOI
https://doi.org/10.1186/s13012-016-0531-2

Other articles of this Issue 1/2017

Implementation Science 1/2017 Go to the issue