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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2017

Open Access 01-12-2017 | Research article

Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria

Authors: Jongsung Lee, Youn Hwa Nho, Seok Kyun Yun, Young Sun Hwang

Published in: BMC Complementary Medicine and Therapies | Issue 1/2017

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Abstract

Background

The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption.

Methods

The anti-bacterial effect of EETC was analyzed using the disc diffusion method. The anti-inflammatory effect of EETC was determined by molecular biological analysis of the DPB-mediated culture cells. Prevention of osteoclastic bone resorption by EETC was explored using osteoclast formation and pit formation assays.

Results

EETC suppressed the growth of oral bacteria and reduced the induction of inflammatory cytokines and proteases, abolishing the expression of PGE2 and COX-2 and inhibiting matrix damage. By stimulating the DPB-derived lipopolysaccharides, EETC inhibited both osteoclast formation in osteoclast precursors and RANKL expression in osteoblasts, thereby contributing to the prevention of bone resorption.

Conclusions

EETC may be a beneficial supplement to help prevent DPB-mediated periodontal disease.
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Metadata
Title
Use of ethanol extracts of Terminalia chebula to prevent periodontal disease induced by dental plaque bacteria
Authors
Jongsung Lee
Youn Hwa Nho
Seok Kyun Yun
Young Sun Hwang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2017
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-017-1619-1

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