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01-04-2011 | Review

Signaling pathways in breast cancer metastasis - novel insights from functional genomics

Authors: Mario Andres Blanco, Yibin Kang

Published in: Breast Cancer Research | Issue 2/2011

Abstract

The advent of genomic profiling technology has brought about revolutionary changes in our understanding of breast cancer metastasis. Gene expression analyses of primary tumors have been used to predict metastatic propensity with high accuracy. Animal models of metastasis additionally offer a platform to experimentally dissect components of the metastasis genetic program. Recent integrated studies have synergized clinical bioinformatic analyses with advanced experimental methodology and begun to uncover the identities and dynamics of signaling programs driving breast cancer metastasis. Such functional genomics studies hold great promise for understanding the genetic basis of metastasis and improving therapeutics for advanced diseases.

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Title: Signaling pathways in breast cancer metastasis - novel insights from functional genomics
Authors: Mario Andres Blanco
Yibin Kang
Publication date: 01-04-2011
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 2/2011
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2831

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