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Open Access 01-12-2013 | Original research

Pilot study of PET imaging of ¹²⁴I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer

Authors: Joseph A O’Donoghue, José G Guillem, Heiko Schöder, Nancy Y Lee, Chaitanya R Divgi, Jeannine A Ruby, John L Humm, Steven A Lee-Kong, Eva M Burnazi, Shangde Cai, Sean D Carlin, Tobias Leibold, Pat B Zanzonico, C Clifton Ling

Published in: EJNMMI Research | Issue 1/2013

Abstract

Background

Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. ¹²⁴I-iodoazomycin galactopyranoside (¹²⁴I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistribution, and imaging characteristics of ¹²⁴I-IAZGP in patients with advanced colorectal cancer and head and neck cancer using serial positron emission tomography (PET) imaging.

Methods

Ten patients underwent serial whole-torso (head/neck to pelvis) PET imaging together with multiple whole-body counts and blood sampling. These data were used to generate absorbed dose estimates to normal tissues for ¹²⁴I-IAZGP. Tumors were scored as either positive or negative for ¹²⁴I-IAZGP uptake.

Results

There were no clinical toxicities or adverse effects associated with ¹²⁴I-IAZGP administration. Clearance from the whole body and blood was rapid, primarily via the urinary tract, with no focal uptake in any parenchymal organ. The tissues receiving the highest absorbed doses were the mucosal walls of the urinary bladder and the intestinal tract, in particular the lower large intestine. All ¹²⁴I-IAZGP PET scans were interpreted as negative for tumor uptake.

Conclusions

It is safe to administer ¹²⁴I-IAZGP to human subjects. However, there was insufficient tumor uptake to support a clinical role for ¹²⁴I-IAZGP PET in colorectal cancer and head and neck cancer patients.

Trial registration

ClinicalTrials.gov NCT00588276

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Title: Pilot study of PET imaging of 124I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer
Authors: Joseph A O’Donoghue
José G Guillem
Heiko Schöder
Nancy Y Lee
Chaitanya R Divgi
Jeannine A Ruby
John L Humm
Steven A Lee-Kong
Eva M Burnazi
Shangde Cai
Sean D Carlin
Tobias Leibold
Pat B Zanzonico
C Clifton Ling
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: EJNMMI Research / Issue 1/2013
Electronic ISSN: 2191-219X
DOI: https://doi.org/10.1186/2191-219X-3-42

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pilot study of PET imaging of ¹²⁴I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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