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Published in: Journal of Medical Case Reports 1/2011

Open Access 01-12-2011 | Case report

Early finding of chest wall metastasis of hepatocellular carcinoma in a woman by fluorodeoxyglucose-positron emission tomography scan: a case report

Authors: Lixin Yang, Howard Marx, Yun Yen

Published in: Journal of Medical Case Reports | Issue 1/2011

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Abstract

Introduction

The use of fluorodeoxyglucose-positron emission tomography to evaluate well-differentiated hepatocellular carcinomas is facing critical problems. It is reported that the activity of fluorodeoxyglucose-6-phosphatase, which converts fluorodeoxyglucose-6-phosphatase to fluorodeoxyglucose, is high in normal liver cells. However, the enzyme-converting activity of glucose-6-phosphatase of well-differentiated hepatocellular carcinomas is similar to normal liver tissue. Thus, using fluorodeoxyglucose in diagnosing primary hepatocellular carcinomas is difficult. However, using fluorodeoxyglucose to detect extrahepatic metastasis of hepatocellular carcinomas is still possible.

Case presentation

We describe the case of a 45-year-old Chinese woman who developed a recurrent lesion in the chest wall from a previous surgically resected hepatocellular carcinoma. This recurrent lesion was detected first on the basis of a positron emission tomography scan, then on the basis of a computed tomography scan and other clinical tests.

Conclusion

This finding indicates that the positron emission tomography scan is a potentially reliable tool to screen for systemic metastatic disease in patients with hepatocellular carcinomas when other cross-sectional imaging tests such as computed tomography or magnetic resonance imaging are negative.
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Literature
1.
go back to reference Parkin DM, Bray F, Ferlay J, Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001, 94: 153-156. 10.1002/ijc.1440.CrossRefPubMed Parkin DM, Bray F, Ferlay J, Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001, 94: 153-156. 10.1002/ijc.1440.CrossRefPubMed
2.
go back to reference Tandon P, Garcia-Tsao G: Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies. Liver Int. 2009, 29: 502-510. 10.1111/j.1478-3231.2008.01957.x.CrossRefPubMedPubMedCentral Tandon P, Garcia-Tsao G: Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies. Liver Int. 2009, 29: 502-510. 10.1111/j.1478-3231.2008.01957.x.CrossRefPubMedPubMedCentral
3.
go back to reference El-Serag HB, Davila JA, Petersen NJ, McGlynn KA: The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med. 2003, 139: 817-823.CrossRefPubMed El-Serag HB, Davila JA, Petersen NJ, McGlynn KA: The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med. 2003, 139: 817-823.CrossRefPubMed
4.
go back to reference Kemp W, Pianko S, Nguyen S, Bailey MJ, Roberts SK: Survival in hepatocellular carcinoma: impact of screening and etiology of liver disease. J Gastroenterol Hepatol. 2005, 20: 873-881. 10.1111/j.1440-1746.2005.03844.x.CrossRefPubMed Kemp W, Pianko S, Nguyen S, Bailey MJ, Roberts SK: Survival in hepatocellular carcinoma: impact of screening and etiology of liver disease. J Gastroenterol Hepatol. 2005, 20: 873-881. 10.1111/j.1440-1746.2005.03844.x.CrossRefPubMed
5.
go back to reference Ariff B, Lloyd CR, Khan S, Shariff M, Thillainayagam AV, Bansi DS, Khan SA, Taylor-Robinson SD, Lim AK: Imaging of liver cancer. World J Gastroenterol. 2009, 15: 1289-1300. 10.3748/wjg.15.1289.CrossRefPubMedPubMedCentral Ariff B, Lloyd CR, Khan S, Shariff M, Thillainayagam AV, Bansi DS, Khan SA, Taylor-Robinson SD, Lim AK: Imaging of liver cancer. World J Gastroenterol. 2009, 15: 1289-1300. 10.3748/wjg.15.1289.CrossRefPubMedPubMedCentral
6.
go back to reference Delbeke D, Martin WH, Sandler MP, Chapman WC, Wright JK, Pinson CW: Evaluation of benign vs malignant hepatic lesions with positron emission tomography. Arch Surg. 1998, 133: 510-516. 10.1001/archsurg.133.5.510.CrossRefPubMed Delbeke D, Martin WH, Sandler MP, Chapman WC, Wright JK, Pinson CW: Evaluation of benign vs malignant hepatic lesions with positron emission tomography. Arch Surg. 1998, 133: 510-516. 10.1001/archsurg.133.5.510.CrossRefPubMed
7.
go back to reference Khan MA, Combs CS, Brunt EM, Lowe VJ, Wolverson MK, Solomon H, Collins BT, Di Bisceglie AM: Positron emission tomography scanning in the evaluation of hepatocellular carcinoma. J Hepatol. 2000, 32: 792-797. 10.1016/S0168-8278(00)80248-2.CrossRefPubMed Khan MA, Combs CS, Brunt EM, Lowe VJ, Wolverson MK, Solomon H, Collins BT, Di Bisceglie AM: Positron emission tomography scanning in the evaluation of hepatocellular carcinoma. J Hepatol. 2000, 32: 792-797. 10.1016/S0168-8278(00)80248-2.CrossRefPubMed
8.
go back to reference Trojan J, Schroeder O, Raedle J, Baum RP, Herrmann G, Jacobi V, Zeuzem S: Fluorine-18 FDG positron emission tomography for imaging of hepatocellular carcinoma. Am J Gastroenterol. 1999, 94: 3314-3319. 10.1111/j.1572-0241.1999.01544.x.CrossRefPubMed Trojan J, Schroeder O, Raedle J, Baum RP, Herrmann G, Jacobi V, Zeuzem S: Fluorine-18 FDG positron emission tomography for imaging of hepatocellular carcinoma. Am J Gastroenterol. 1999, 94: 3314-3319. 10.1111/j.1572-0241.1999.01544.x.CrossRefPubMed
9.
go back to reference Ho CL, Chen S, Yeung DW, Cheng TK: Dual-tracer PET/CT imaging in evaluation of metastatic hepatocellular carcinoma. J Nucl Med. 2007, 48: 902-909. 10.2967/jnumed.106.036673.CrossRefPubMed Ho CL, Chen S, Yeung DW, Cheng TK: Dual-tracer PET/CT imaging in evaluation of metastatic hepatocellular carcinoma. J Nucl Med. 2007, 48: 902-909. 10.2967/jnumed.106.036673.CrossRefPubMed
10.
go back to reference Iwata Y, Shiomi S, Sasaki N, Jomura H, Nishiguchi S, Seki S, Kawabe J, Ochi H: Clinical usefulness of positron emission tomography with fluorine-18-fluorodeoxyglucose in the diagnosis of liver tumors. Ann Nucl Med. 2000, 14: 121-126. 10.1007/BF02988591.CrossRefPubMed Iwata Y, Shiomi S, Sasaki N, Jomura H, Nishiguchi S, Seki S, Kawabe J, Ochi H: Clinical usefulness of positron emission tomography with fluorine-18-fluorodeoxyglucose in the diagnosis of liver tumors. Ann Nucl Med. 2000, 14: 121-126. 10.1007/BF02988591.CrossRefPubMed
11.
go back to reference Schwarz RE, Smith DD: Trends in local therapy for hepatocellular carcinoma and survival outcomes in the US population. Am J Surg. 2008, 195: 829-836. 10.1016/j.amjsurg.2007.10.010.CrossRefPubMed Schwarz RE, Smith DD: Trends in local therapy for hepatocellular carcinoma and survival outcomes in the US population. Am J Surg. 2008, 195: 829-836. 10.1016/j.amjsurg.2007.10.010.CrossRefPubMed
12.
go back to reference Hyun YS, Choi HS, Bae JH, Jun DW, Lee HL, Lee OY, Yoon BC, Lee MH: Hyun YS, Choi HS, Bae JH, Jun DW, Lee HL, Lee OY, Yoon BC, Lee MH:
13.
go back to reference Lee DH, Kee CS, Kang JH, Park MH: Chest wall metastasis from unknown primary site of hepatocellular carcinoma. World J Gastroenterol. 2006, 12: 2139-2142.CrossRefPubMedPubMedCentral Lee DH, Kee CS, Kang JH, Park MH: Chest wall metastasis from unknown primary site of hepatocellular carcinoma. World J Gastroenterol. 2006, 12: 2139-2142.CrossRefPubMedPubMedCentral
14.
go back to reference Park JW, Kim JH, Kim SK, Kang KW, Park KW, Choi JI, Lee WJ, Kim CM: Park JW, Kim JH, Kim SK, Kang KW, Park KW, Choi JI, Lee WJ, Kim CM:
15.
go back to reference Nam BH: A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma. J Nucl Med. 2008, 49: 1912-1921. 10.2967/jnumed.108.055087.CrossRefPubMed Nam BH: A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma. J Nucl Med. 2008, 49: 1912-1921. 10.2967/jnumed.108.055087.CrossRefPubMed
16.
go back to reference Sugiyama M, Sakahara H, Torizuka T, Kanno T, Nakamura F, Futatsubashi M, Nakamura S: 18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma. J Gastroenterol. 2004, 39: 961-968. 10.1007/s00535-004-1427-5.CrossRefPubMed Sugiyama M, Sakahara H, Torizuka T, Kanno T, Nakamura F, Futatsubashi M, Nakamura S: 18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma. J Gastroenterol. 2004, 39: 961-968. 10.1007/s00535-004-1427-5.CrossRefPubMed
17.
go back to reference Chen YK, Hsieh DS, Liao CS, Bai CH, Su CT, Shen YY, Hsieh JF, Liao AC: Chen YK, Hsieh DS, Liao CS, Bai CH, Su CT, Shen YY, Hsieh JF, Liao AC:
18.
go back to reference Kao CH: Utility of FDG-PET for investigating unexplained serum AFP elevation in patients with suspected hepatocellular carcinoma recurrence. Anticancer Res. 2005, 25: 4719-4725.PubMed Kao CH: Utility of FDG-PET for investigating unexplained serum AFP elevation in patients with suspected hepatocellular carcinoma recurrence. Anticancer Res. 2005, 25: 4719-4725.PubMed
Metadata
Title
Early finding of chest wall metastasis of hepatocellular carcinoma in a woman by fluorodeoxyglucose-positron emission tomography scan: a case report
Authors
Lixin Yang
Howard Marx
Yun Yen
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2011
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-5-147

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