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Breast Cancer
Published in: Breast Cancer 3/2016

Open Access 01-05-2016 | Original Article

Flap adhesion and effect on postoperative complication rates using Tissuglu® in mastectomy patients

Authors: Christian Eichler, Petra Fischer, Axel Sauerwald, Faten Dahdouh, Mathias Warm

Published in: Breast Cancer | Issue 3/2016

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Abstract

Introduction

Post-mastectomy seroma and related complications are common problems in modern oncological surgery. Occurrence rates of up to 59 % have been reported in literature. High-risk patients, that is, those who have undergone previous surgeries, present with a high body mass index, have had radiation or chemotherapy, present a particular challenge. Noninvasive measures such as fibrin-based sealants have thus far not been able to effectively reduce complications associated with fluid accumulation. A recent study using a lysine-derived urethane adhesive named TissuGlu® however, showed promising results in patients after abdominoplasty.

Methods

32 consecutively recruited patients received a mastectomy using a gold standard mastectomy technique as well as TissuGlu® flap fixation. A control group of 173 patients, having received a gold standard mastectomy-only, was analyzed retrospectively, totaling 205 patients. Primary endpoints were post-discharge seroma formation and revision surgery/re-hospitalization. Secondary endpoints were initial seroma volume, postoperative pain, hematoma formation and day of drain removal.

Results

No significant difference in seroma formation was demonstrated. The revision surgery/re-hospitalization rate was reduced from 6.9 to 0 %, though this did not reach significance. Significant improvement could be shown in the TissuGlu® group regarding time to drain removal (17 % decrease), and hematoma formation (14 % decrease). No difference was shown in postoperative pain.

Conclusion

Although patient numbers are still small, advantages in revision surgery/re-hospitalization rate, hematoma formation as well as time to drain removal was shown for the TissuGlu® group.

Clinical question/level of evidence

Therapeutic, IV.
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Metadata
Title
Flap adhesion and effect on postoperative complication rates using Tissuglu® in mastectomy patients
Authors
Christian Eichler
Petra Fischer
Axel Sauerwald
Faten Dahdouh
Mathias Warm
Publication date
01-05-2016
Publisher
Springer Japan
Published in
Breast Cancer / Issue 3/2016
Print ISSN: 1340-6868
Electronic ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-015-0591-1

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