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Open Access 01-09-2016 | Original Article

Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue

Authors: Anna Pokryszko-Dragan, Mieszko Zagrajek, Krzysztof Slotwinski, Malgorzata Bilinska, Ewa Gruszka, Ryszard Podemski

Published in: Neurological Sciences | Issue 9/2016

Abstract

The aim of this study was to evaluate event-related potentials (ERP) and cognition in multiple sclerosis (MS) patients with regard to fatigue and disease-related variables. The study comprised 86 MS patients and 40 controls. Fatigue was assessed using the Fatigue Severity Scale (FSS/FSS-5) and the Modified Fatigue Impact Scale (MFIS/MFISmod). N200 and P300 components of auditory ERP were analyzed. Cognition was evaluated by means of Brief Repeatable Battery of Neuropsychological Tests (BRBNT). The results of ERP and BRBNT were compared between non-fatigued, moderately and severely fatigued MS patients and controls. P300 latency was significantly longer in the whole MS group and in the fatigued patients than in the controls. A positive correlation was found between P300 latency and MFIS/MFISmod results, independent from age and MS-related variables. The fatigued patients scored less than non-fatigued ones in tests evaluating memory, visuomotor abilities and attention. Results of these tests correlated significantly with fatigue measures, independently from MS-related variables. Fatigue in MS patients showed significant relationships with impairment within the memory and attention domains. Parameters of auditory ERP, as electrophysiological biomarkers of cognitive performance, were not independently linked to fatigue.

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Title: Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue
Authors: Anna Pokryszko-Dragan
Mieszko Zagrajek
Krzysztof Slotwinski
Malgorzata Bilinska
Ewa Gruszka
Ryszard Podemski
Publication date: 01-09-2016
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 9/2016
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-016-2622-x

At a glance: The STEP trials

Springer Medicine

Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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