Skip to main content
Top
Published in: Archives of Gynecology and Obstetrics 2/2016

Open Access 01-02-2016 | Maternal-Fetal Medicine

Temporal trends in fetal mortality at and beyond term and induction of labor in Germany 2005–2012: data from German routine perinatal monitoring

Authors: Christiane Schwarz, Rainhild Schäfers, Christine Loytved, Peter Heusser, Michael Abou-Dakn, Thomas König, Bettina Berger

Published in: Archives of Gynecology and Obstetrics | Issue 2/2016

Login to get access

Abstract

Purpose

While a variety of factors may play a role in fetal and neonatal deaths, postmaturity as a cause of stillbirth remains a topic of debate. It still is unclear, whether induction of labor at a particular gestational age may prevent fetal deaths.

Methods

A multidisciplinary working group was granted access to the most recent set of relevant German routine perinatal data, comprising all 5,291,011 hospital births from 2005 to 2012. We analyzed correlations in rates of induction of labor (IOL), perinatal mortality (in particular stillbirths) at different gestational ages, and fetal morbidity. Correlations were tested with Pearson’s product-moment analysis (α = 5 %). All computations were performed with SPSS version 22.

Results

Induction rates rose significantly from 16.5 to 21.9 % (r = 0.98; p < 0.001). There were no significant changes in stillbirth rates (0.28–0.35 per 100 births; r = 0.045; p = 0.806). Stillbirth rates 2009–2012 remained stable in all gestational age groups irrespective of induction. Fetal morbidity (one or more ICD-10 codes) rose significantly during 2005–2012. This was true for both children with (from 33 to 37 %, r = 0.784, p < 0.001) and without (from 25 to 31 %, (r = 0.920, p < 0.001) IOL.

Conclusions

An increase in IOL at term is not associated with a decline in perinatal mortality. Perinatal morbidity increased with and without indiction of labor.
Literature
2.
go back to reference Stock SJ, Ferguson E, Duffy A, Ford I, Chalmers J, Norman JE (2012) Outcomes of elective induction of labour compared with expectant management: population based study. BMJ 344:e2838PubMedPubMedCentralCrossRef Stock SJ, Ferguson E, Duffy A, Ford I, Chalmers J, Norman JE (2012) Outcomes of elective induction of labour compared with expectant management: population based study. BMJ 344:e2838PubMedPubMedCentralCrossRef
6.
go back to reference Dunne C, Da Silva O, Schmidt G, Natale R (2009) Outcomes of elective labour induction and elective caesarean section in low-risk pregnancies between 37 and 41 weeks’ gestation. J Obstet Gynaecol Can 31:1124–1130PubMed Dunne C, Da Silva O, Schmidt G, Natale R (2009) Outcomes of elective labour induction and elective caesarean section in low-risk pregnancies between 37 and 41 weeks’ gestation. J Obstet Gynaecol Can 31:1124–1130PubMed
7.
go back to reference Bodner-Adler B, Bodner K, Pateisky N, Kimberger O, Chalubinski K, Mayerhofer K, Husslein P (2005) Influence of labor induction on obstetric outcomes in patients with prolonged pregnancy: a comparison between elective labor induction and spontaneous onset of labor beyond term. Wien Klin Wochenschr 117:287–292PubMedCrossRef Bodner-Adler B, Bodner K, Pateisky N, Kimberger O, Chalubinski K, Mayerhofer K, Husslein P (2005) Influence of labor induction on obstetric outcomes in patients with prolonged pregnancy: a comparison between elective labor induction and spontaneous onset of labor beyond term. Wien Klin Wochenschr 117:287–292PubMedCrossRef
9.
go back to reference Ecker JL, Chen KT, Cohen AP, Riley LE, Lieberman ES (2001) Increased risk of cesarean delivery with advancing maternal age: indications and associated factors in nulliparous women. Am J Obstet Gynecol 185:883–887. doi:10.1067/mob.2001.117364 PubMedCrossRef Ecker JL, Chen KT, Cohen AP, Riley LE, Lieberman ES (2001) Increased risk of cesarean delivery with advancing maternal age: indications and associated factors in nulliparous women. Am J Obstet Gynecol 185:883–887. doi:10.​1067/​mob.​2001.​117364 PubMedCrossRef
11.
go back to reference Flenady V, Koopmans L, Middleton P, Frøen JF, Smith GC, Gibbons K, Coory M, Gordon A, Ellwood D, McIntyre HD, Fretts R, Ezzati M (2011) Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet 377:1331–1340. doi:10.1016/S0140-6736(10)62233-7 PubMedCrossRef Flenady V, Koopmans L, Middleton P, Frøen JF, Smith GC, Gibbons K, Coory M, Gordon A, Ellwood D, McIntyre HD, Fretts R, Ezzati M (2011) Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet 377:1331–1340. doi:10.​1016/​S0140-6736(10)62233-7 PubMedCrossRef
13.
go back to reference Ravelli ACJ, Schaaf JM, Eskes M, Abu-Hanna A, de Miranda E, Mol BWJ (2013) Ethnic disparities in perinatal mortality at 40 and 41 weeks of gestation. J Perinat Med 41:381–388. doi:10.1515/jpm-2012-0228 PubMed Ravelli ACJ, Schaaf JM, Eskes M, Abu-Hanna A, de Miranda E, Mol BWJ (2013) Ethnic disparities in perinatal mortality at 40 and 41 weeks of gestation. J Perinat Med 41:381–388. doi:10.​1515/​jpm-2012-0228 PubMed
20.
23.
26.
go back to reference Schwarz C, Weiss E, Loytved C, Schäfers R, König T, Heusser P, Berger B (2015) Fetale Mortalität bei Einlingen ab Termin–eine Analyse bundesdeutscher Perinataldaten 2004–2013. Z Geburtshilfe Neonatol. doi:10.1055/s-0034-1398659 PubMed Schwarz C, Weiss E, Loytved C, Schäfers R, König T, Heusser P, Berger B (2015) Fetale Mortalität bei Einlingen ab Termin–eine Analyse bundesdeutscher Perinataldaten 2004–2013. Z Geburtshilfe Neonatol. doi:10.​1055/​s-0034-1398659 PubMed
28.
go back to reference National Collaborating Centre for Women’s and Children’s Health (2008) Induction of labour National Collaborating Centre for Women’s and Children’s Health (2008) Induction of labour
29.
30.
go back to reference Allen VM, Stewart A, O’Connell CM, Baskett TF, Vincer M, Allen AC (2012) The influence of changing post-term induction of labour patterns on severe neonatal morbidity. J Obstet Gynaecol Can 34:330–340PubMed Allen VM, Stewart A, O’Connell CM, Baskett TF, Vincer M, Allen AC (2012) The influence of changing post-term induction of labour patterns on severe neonatal morbidity. J Obstet Gynaecol Can 34:330–340PubMed
31.
go back to reference Helgadóttir LB, Turowski G, Skjeldestad FE, Jacobsen AF, Sandset PM, Roald B, Jacobsen E-M (2013) Classification of stillbirths and risk factors by cause of death—a case-control study. Acta Obstet Gynecol Scand 92:325–333. doi:10.1111/aogs.12044 PubMedCrossRef Helgadóttir LB, Turowski G, Skjeldestad FE, Jacobsen AF, Sandset PM, Roald B, Jacobsen E-M (2013) Classification of stillbirths and risk factors by cause of death—a case-control study. Acta Obstet Gynecol Scand 92:325–333. doi:10.​1111/​aogs.​12044 PubMedCrossRef
33.
go back to reference Stormdal Bring H, Hulthén Varli IA, Kublickas M, Papadogiannakis N, Pettersson K (2014) Causes of stillbirth at different gestational ages in singleton pregnancies. Acta Obstet Gynecol Scand 93:86–92. doi:10.1111/aogs.12278 PubMedCrossRef Stormdal Bring H, Hulthén Varli IA, Kublickas M, Papadogiannakis N, Pettersson K (2014) Causes of stillbirth at different gestational ages in singleton pregnancies. Acta Obstet Gynecol Scand 93:86–92. doi:10.​1111/​aogs.​12278 PubMedCrossRef
34.
go back to reference Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG) (2014) S1-Leitlinie: Vorgehen bei Terminüberschreitung und Übertragung Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG) (2014) S1-Leitlinie: Vorgehen bei Terminüberschreitung und Übertragung
35.
go back to reference Committee MM (2001) SOGC Clinical Practice Guideline. Induction of Labour at Term. J Obs Gynaecol Can 1–12 Committee MM (2001) SOGC Clinical Practice Guideline. Induction of Labour at Term. J Obs Gynaecol Can 1–12
36.
go back to reference WHO (2011) WHO recommendations for induction of labour WHO (2011) WHO recommendations for induction of labour
Metadata
Title
Temporal trends in fetal mortality at and beyond term and induction of labor in Germany 2005–2012: data from German routine perinatal monitoring
Authors
Christiane Schwarz
Rainhild Schäfers
Christine Loytved
Peter Heusser
Michael Abou-Dakn
Thomas König
Bettina Berger
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 2/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-015-3795-x

Other articles of this Issue 2/2016

Archives of Gynecology and Obstetrics 2/2016 Go to the issue