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Pediatric Surgery International

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Open Access 01-03-2012 | Original Article

Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children

Authors: Wei Hao, Ivy H. Y. Chan, XueLai Liu, Paula M. Y. Tang, Paul K. H. Tam, Kenneth K. Y. Wong

Published in: Pediatric Surgery International | Issue 3/2012

Abstract

Purpose

Laparoendoscopic single-site surgery has recently been described in children and regarded as an improved technology leading to less pain and better cosmetic outcome. Compared to the traditional three-port method, it is not known if the single-port method is less invasive. The aim of this study was thus to investigate the post-operative acute inflammatory response in order to evaluate surgical stress in the two surgical approaches in children.

Methods

A prospective, single blinded, case-control study was carried out. Thirteen male patients who presented with unilateral varicocele were divided into two groups. Six children underwent single-port laparoscopic procedure, while the other seven children underwent three-port laparoscopic procedure. Pre-operative and post-operative blood samples were taken for the measurement of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) using ELISA. Demographics including the operation time, and complications were recorded. Data between the two groups were analyzed using unpaired t-test and a p value of <0.05 was taken as statistically significant.

Results

The mean age of patients was 14.5 years (range 12–19 years). There was no significant difference between the two groups in terms of operative time, nor there was any complication recorded. The change in serum TNF-α and IL-6 concentrations pre- and post-operatively between the single-port group and three-port group was not statistically significant. Overall, patients in the two groups showed excellent satisfaction in terms of post-operative cosmesis.

Conclusion

Single-port laparoscopic varicocelectomy is safe, effective and produces excellent cosmesis with minimal surgical stress.

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Title: Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children
Authors: Wei Hao
Ivy H. Y. Chan
XueLai Liu
Paula M. Y. Tang
Paul K. H. Tam
Kenneth K. Y. Wong
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 3/2012
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-011-3011-4

At a glance: The STEP trials

Springer Medicine

Early post-operative interleukin-6 and tumor necrosis factor-α levels after single-port laparoscopic varicocelectomy in children

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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