Issue Special Issue 1/2004
24th European Workshop for Rheumatology Research
Content (106 Articles)
Differential antibody recognition of the 349–364aa B-cell epitope of human La/SSB protein and its phosphorylated analogue
AG Terzoglou, JG Routsias, HM Moutsopoulos, AG Tzioufas
Surface-bound immune complexes containing antibodies to collagen type II induce production of TNF-α, IL-1β and IL-8 from monocytes via FcγRII
M Mullazehi, L Mathsson, J Lampa, J Rönnelid
Prothrombin fragment F1+2 in patients with antiphospholipid antibodies
A Ambrozic, B Bozic, S Cucnik, T Kveder, B Rozman
Concomitant appearance of anti-cardiolipin, anti-β2-glycoprotein I, anti-prothrombin and anti-annexin V antibodies
S Cucnik, N Gaspersic, T Kveder, B Bozic
Antibodies against 25-mer synthetic peptide of M3 muscarinic acetylcholine receptor
P Zigon, A Hocevar, S Cucnik, B Bozic, B Rozman, M Tomsic, T Kveder
Association of anti-ribosomal P protein antibodies with neuropsychiatric systemic lupus erythematosus
A Ambrozic, B Bozic, B Rozman, B Lestan, T Kveder
Human cartilage glycoprotein 39-directed T cell responses in health and arthritic diseases
JHM van Bilsen, LR Lard, EIH van der Voort, D Elferink, A Bakker, H van Dongen, AMM Miltenburg, T Huizinga, R de Vries, REM Toes
Multiplex analysis of antinuclear antibodies by flow cytometry using FIDIS
PJ Charles
Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice
BF Hoyer, K Moser, AE Hauser, A Peddinghaus, C Voigt, D Eilat, A Radbruch, RA Manz, F Hiepe
Immune complexes from RA patients induce FcγRII-dependent and RF-correlated TNF-α and IL-8 production from healthy PBMC
L Mathsson, J Lampa, M Mullazehi, J Rönnelid
Differential regulation of the expression of chemokine receptor 3 and 4 during plasma cell differentiation
G Muehlinghaus, L Cigliano, H Leyendeckers, S Arce, A Radbruch, RA Manz
Two B cell populations differentially expressing IgVH mRNAs in human RA synovium
S Ruzickova, O Krystufkova, L Sedova, J Niederlova, Z Cimburek, T Dörner, J Vencovsky
Immunomics in inflammatory rheumatic diseases
Z Konthur, K Adolph, G Burguera, A Sternjak, A Förster, H Lehrach, GR Burmester, K Skriner
VIDAS-EDRA fully automated testing of autoantibodies to citrullinated proteins for the diagnosis of rheumatoid arthritis
L Nogueira, A Foussadier, C Vincent, C Clavel, N Moinard, M Jolivet, G Serre
Features of the citrullinating peptidylarginine deiminase enzymes
ER Vossenaar, AJW Zendman, R Raijmakers, TJ Welting, A van der Heijden, WAM Horstman, JH Vogelzangs, S Nijenhuis, WJ van Venrooij, GJM Pruijn
False positivity of rheumatoid factor and antibodies to citrullinated peptides in systemic lupus erythematosus
IEA Hoffman, I Peene, A Union, L Meheus, T Huizinga, L Cebecauer, D Isenberg, K De Bosschere, F Hulstaert, EM Veys, F De Keyser
Diagnostic performance and predictive value of serum markers for the diagnosis of rheumatoid arthritis
IEA Hoffman, I Peene, A Union, L Meheus, L De Clercq, L Schatteman, S Poriau, H Mielants, EM Veys, F De Keyser
Citrullinated proteins in arthritis: presence in joints and effects on immunogenicity
K Lundberg, S Nijenhuis, E Vossenaar, L Klareskog, WJ van Venrooij, H Erlandsson Harris
Antifilaggrin antibodies in serum and synovial fluid samples of patients with rheumatoid arthritis show similar reactivity pattern towards citrulline containing peptides
M Brózik, A Magyar, R Tobi, G Bálint, ZS Balogh, A Polgár, F Hudecz, K Merétey
The presence of deiminated fibrin in the synovial membrane is not specific for rheumatoid arthritis
S Chapuy-Regaud, M Sebbag, D Baeten, C Clavel, F De Keyser, G Serre
The rheumatoid arthritis specific Sa antigen is citrullinated vimentin
ER Vossenaar, N Depres, M Lora, A van der Heijden, E Lapointe, AJW Zendman, T Senshu, WJ van Venrooij, HA Ménard
Elevated expression of IL-18 in Sjögren's syndrome: distinct expression patterns of the active and proactive forms
S Boiu-Zahiu, EK Kapsogeorgou, ID Dimitriou, MP Spahidou, HM Moutsopoulos, MN Manoussakis
Cytokine imbalance in NZB/W mice is associated with autoantibody levels and nephritis
P Enghard, D Langnickel, F Hiepe, GR Burmester, G Riemekasten
Anti-tumour necrosis factor therapy modulates the OPG/OPGL system in rheumatoid arthritis synovium
AI Catrina, S Ernestam, E af Klint, L Klareskog, AK Ulfgren
IL-20 is expressed in inflamed synovium of patients with psoriatic arthritis and rheumatoid arthritis
TJM Smeets, Y Chandrasekher, JJ Haringman, PP Tak
Cross-talk between TRAIL and TGF-β in regulation of collagen production in scleroderma lung disease
VV Yurovsky
Effects of reduced ATP-formation on cytokine production and proliferation in human peripheral CD4+ T cells
R Tripmacher, T Gaber, GR Burmester, A Radbruch, A Scheffold
Intra-articular steroid treatment reduces synovial HMGB1 but not IL-1 expression in chronic arthritis
C Grundtman, E af Klint, U Andersson, L Klareskog, A Ulfgren
IL-1-dependent cartilage damage in a macrophage-driven arthritis model can be circumvented by T cell IL-17
MI Koenders, E Lubberts, LAB Joosten, JK Kolls, WB van den Berg
IL-13 overexpression during immune complex arthritis diminishes MMP-mediated VDIPEN expression
KC Nabbe, PL van Lent, AE Holthuysen, AE Koch, WB van den Berg
Overexpression of TNF causes bilateral sacroiliitis
K Redlich, B Görtz, S Hayer, J Zwerina, G Kollias, G Steiner, JS Smolen, G Schett
Characterization of the T cell response to hnRNP-A2 (RA33) in HLA-DR4 transgenic mice
M Hoffmann, S Trembleau, S Hayer, JS Smolen, G Steiner
Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCP) affects severity of rheumatoid arthritis
FA van Gaalen, J van Aken, TWJ Huizinga, GMTh Schreuder, FC Breedveld, E Zanelli, WJ van Venrooij, CL Verweij, RRP de Vries, REM Toes
HLA-DRB1 encoded predisposition to rheumatoid arthritis: the anchor hypothesis
N de Vries, H Tijssen, PLCM van Riel, LBA van de Putte, PP Tak
Influence of the physicochemical properties of the HLA-DRB1 shared epitope negative alleles on rheumatoid arthritis susceptibility
L Michou, E Petit-Teixeira, I Lemaire, C Pierlot, J Osorio, W Frigui, S Lasbleiz, P Quillet, T Bardin, B Prum, F Cornélis
CD28nullCD4+ T cells: an effector memory T cell population in patients with rheumatoid arthritis
AER Fasth, D Cao, R van Vollenhoven, C Trollmo, V Malmström
Autoreactive T cells specific for a natural intracellular hapten: an example from patients with acute myocarditis and possible consequences for other inflammatory diseases
I Melchers, G Cicek, E Schiltz, J Staiger, F-J Neumann, R Brandsch
T cell response in Shigella-induced reactive arthritis
H Brandt, U Stelzl, W Kuon, T Adam, KH Nierhaus, J Sieper
CD25+regulatory T cells can be used therapeutically in collagen-induced arthritis
ME Morgan, R Flierman, HJ Witteveen, TWJ Huizinga, RRP de Vries, REM Toes
Characterization of kidney infiltrating T cells in the NZB/W F1 lupus model
P Enghard, D Langnickel, GR Burmester, F Hiepe, A Radbruch, G Riemekasten
CD25brightCD4+ regulatory T cells accumulate in inflamed joints of patients with chronic rheumatic disease
D Cao, R van Vollenhoven, L Klareskog, C Trollmo, V Malmström
Increased expression of chemokines DC-CK1, ELC and TARC by dendritic cells and in synovium from patients with rheumatoid arthritis
T Radstake, R van der Voort, A Sloetjes, C Figdor, W van den Berg, P Barrera, G Adema
Effect of an empty plasmid containing CpG on dendritic cells: in vitro steady state of stimulation, in vivo prevention of collagen-induced arthritis
O Jaen, MC Boissier, G Falgarone
RANK and RANKL expression in rheumatoid arthritis synovium and lymph nodes as markers of dendritic cell – T cell interactions
G Page, P Miossec
Characterization of BDCA1 and BDCA4 dendritic cell subsets in rheumatoid arthritis patients
MC Lebre, SW Tas, P Reinders-Blankert, TJM Smeets, PP Tak
Differential dendritic cell expression in chronic inflammatory arthritis: implications for their maturation, recruitment and involvement in disease
S Jongbloed, A Fraser, JA Gracie, IB McInnes
Triggering of FcGR during dendritic cell maturation leads to a decreased expression of the chemokines DC-CK1, ELC and TARC
TRDJ Radstake, R van der Voort, C Figdor, W van den Berg, P Barrera, GJ Adema
Phenotypic and functional deficiencies of monocyte derived dendritic cells in systemic lupus erythematosus patients
C Scheinecker, M Köller, B Zwölfer, JS Smolen
Vaccination with TNF-α modulated DCs protects against CIA in an antigen-specific manner
LM van Duivenvoorde, P Louis-Plence, F Apparailly, EIH van der Voort, TJW Huizinga, C Jorgensen, REM Toes
The effects of NF-κB inhibition by a NEMO binding domain peptide in vitro and in vivo
SW Tas, EC de Jong, MJ Vervoordeldonk, KA Reedquist, M May, S Ghosh, PP Tak
CD44 regulates bone erosion and osteoclastogenesis in arthritis
S Hayer, B Goertz, J Zwerina, K Redlich, O Hoffmann, M Amling, F Hilberg, G Kollias, G Steiner, EF Wagner, JS Smolen, G Schett
Differential gene expression and protein expression levels of MMP and TIMP molecules in response to glucocorticoid treatment in arthritic patients
T Andersson, E af Klint, S Strobel, U Andersson, A Stark, R Gelinas, J Lundeberg, L Klareskog, A-K Ulfgren
Local interferon-β gene therapy ameliorates adjuvant arthritis in rats
P Adriaansen, J Van Holten, C Kaynor, MJ Vervoordeldonk, PP Tak
Neutralizing synovial RANKL by local OPG gene therapy in collagen-induced arthritis prevents cartilage erosion through induction of a non-destructive type 2 synovitis
E Lubberts, MI Koenders, B Oppers-Walgreen, M Wagenmans, L van den Bersselaar, LAB Joosten, J Schurr, JK Kolls, WB van den Berg
Bone morphogenic protein (BMP-2) enhances expression of type II collagen and aggrecan in human chondrocytes in 3D alginate cultures
WK Aicher, B Thunemann, C Gaissmaier, J Fritz, T Gründer
Human bone marrow-derived mesenchymal stem cells: studies on chondrogenic differentiation, chemotaxis and recruitment
J Ringe, S Straßburg, M Endres, M Notter, T Haeupl, R Manz, C Kaps, M Sittinger
Requirement of local synovial IL-17 receptor signaling in the progression of chronic synovitis and bone erosion in arthritis
E Lubberts, W Huang, P Schwarzenberger, J Schurr, J Peschon, WB van den Berg, JK Kolls
TRAIL-induced rheumatoid arthritis fibroblast-like synoviocyte proliferation is inhibited by OPG
J Morel, R Audo, V Deschamps, B Combe
Expression of TRAIL-R2 (DR5) on fibroblasts from synovial fluid of rheumatoid arthritis
E Miranda, A Balsa, M Benito, C Pérez de Ayala, E Martín-Mola
The active metabolite of leflunomide, A77-1726, increases proliferation of human synovial fibroblasts in presence of IL-1β
D Magne, F Mezin, G Palmer, PA Guerne
Protection of inflammation-related bone loss by OPG and TNF-α antibodies through distinct mechanisms in collagen-induced arthritis
N Saidenberg-Kermanach, A Corrado, N Bessis, D Lemeiter, MC de Vernejoul, MC Boissier, M Cohen-Solal
Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-TNF in combination with OPG or PTH in TNF-mediated arthritis
K Redlich, B Görtz, S Hayer, J Zwerina, N Doerr, P Kostenuik, G Kollias, G Steiner, JS Smolen, G Schett
Histochemical detection of oxidative stress in synovial tissue: spontaneous reactive oxygen species (ROS) production by rheumatoid arthritis T cells
PHJ Remans, WM Fredericks, PP Tak, FC Breedveld, JM van Laar, KA Reedquist
Immunization with the glycolytic enzyme glucose-6-phosphate isomerase (GPI) induces peripheral polyarthritis in genetically unaltered mice
D Schubert, B Maier, L Morawietz, V Krenn, T Kamradt
Differential expression and response to infliximab treatment of specific macrophage subsets in inflammatory synovitis
L De Rycke, D Baeten, D Foell, E Kruithof, EM Veys, J Roth, F De Keyser
Involvement of SUMO-1 in the regulation of apoptosis in prosthesis loosening fibroblasts
I Meinecke, A Wille, A Cinski, W Neumann, B Ink, R Hay, S Gay, T Pap
Monocyte-specific gene signatures in rheumatoid arthritis
A Grützkau, J Grün, M Rudwaleit, L Goldschmidt, G-R Burmester, A Radbruch, T Häupl
A customized monocyte cDNA microarray for diagnosis of rheumatoid arthritis and prognosis of anti-TNF-α therapy
B Stuhlmüller, N Tandon, C Hultschig, RJ Kuban, M Hernandez, GR Burmester, T Häupl
Reporter cell lines for real-time imaging of NF-κB activation in the arthritic joint
RL Smeets, LAB Joosten, WB van den Berg, FAJ van de Loo
Differential regulation of mitogenic activated protein kinases by thymosin β4 sulphoxide (Tb4SO)
M Junghae, JD Young, JA Gracie, IB McInnes
Polymorphism at the position -308 of TNF-α gene influences outcome of infliximab therapy in rheumatoid arthritis
B Mugnier, D Reviron, A Darque, N Balandraud, C Roudier, J Roudier
Unraveling complexity of rheumatoid synovial gene expression by comparison with purified leukocyte profiles
T Häupl, A Grützkau, J Grün, R Baumgrass, M Janitz, B Stuhlmüller, T Rohrlach, C Kaps, M Rudwaleit, L Morawietz, J Zacher, V Krenn, G-R Burmester, A Radbruch
B lymphocytes infiltrating Wegener's granuloma: the immunoglobulin VH gene repertoire from granulomatous tissues displays an antigen-driven maturation and suggests a microbial trigger
J Voswinkel, J Krämer, A Müller, K Herlyn, P Lamprecht, WL Gross, A Gause
Toll-like receptor 4 polymorphism influences susceptibility to but not severity and outcome of rheumatoid arthritis
TRDJ Radstake, B Franke, S Hanssen, P Welsing, LAB Joosten, PLCM van Riel, P Barrera, WB van den Berg
Radiological sacroiliitis is linked with CARD15 gene polymorphisms in patients with Crohn's disease
B Vander Cruyssen, H Peeters, D Laukens, P Coucke, H Mielants, M De Vos, F De Keyser
Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence for the existence of distinctive pathways relevant to disease
PV Kasperkovitz, NL Verbeet, T Smeets, PP Tak, TWJ Huizinga, B Baltus, T Timmer, E Pieterman, M Fero, GS Firestein, AA Alizadeh, TCTM van der Pouw Kraan, CL Verweij
Host immune responses to salivary gland administration of recombinant adeno-associated virus serotype 2 vectors
MR Kok, A Voutetakis, S Yamano, J Wang, A Cotrim, H Katano, I Bossis, JA Chiorini, PP Tak, BJ Baum
Switching of serotype can improve local AAV-mediated gene therapy in RA
J Adriaansen, M Vervoordeldonk, P Plence, A Bakker, E Gicquel, C Jorgensen, PP Tak, F Apparailly
Suppressor of cytokine signaling (SOCS)-3 gene transfer protects against collagen-induced arthritis
FAJ van de Loo, RL Smeets, LAB Joosten, WB van den Berg
IL-22 gene transfer in collagen-induced arthritis
F Apparailly, J Dudler, J-C Renauld, P Plence, L Dumoutier, F Djouad, D Noel, AK So, J Sany, C Jorgensen
Nonviral gene therapy by electrotransfer of hTNF-α soluble receptor variants: application to the treatment of collagen arthritis
C Bloquel, P Bigey, D Scherman, MC Boissier, N Bessis
Application of regulatable vectors in gene therapy of experimental arthritis
DJ Gould, Y Chernajovsky
Long-term immune reconstitution in patients treated with autologous stem cell transplantation for refractory autoimmune diseases
T Alexander, G Massenkeil, GR Burmester, A Radbruch, R Arnold, F Hiepe, A Thiel
Zoledronic acid protects from local and systemic bone loss in TNF-mediated arthritis
J Zwerina, P Herrak, B Goertz, S Hayer, K Redlich, E Reiter, J Gasser, H Bergmeister, G Kollias, JS Smolen, G Schett
Abatacept (CTLA4Ig) treatment increases the remission rate in rheumatoid arthritis patients refractory to methotrexate treatment
R Westhovens, P van Riel, J Sibilia, G Vratsanos, I Nuamah, JC Becker
Multidrug resistance proteins and DMARD efficacy in rheumatoid arthritis
G Jansen, R Oerlemans, J van der Heijden, WF Lems, GL Scheffer, RJ Scheper, BAC Dijkmans
Impact of cellular therapies on autoreactive, long-lived plasma cells in autoimmune diseases (AID)
F Hiepe, R Manz, B Hoyer, A Thiel, T Alexander, G-R Burmester, G Massenkeil, R Arnold, A Radbruch
Addition of cyclosporine-A (Neoral®) in patients on anti-TNF and methotrexate therapy improves disease activity: an open-label, pilot study
P Sidiropoulos, P Siakka, M Mamoulaki, H Kouroumali, H Kritikos, DT Boumpas
Effects of anti-TNF therapy on endothelial function and intima–media thickness of common carotid artery in patients with rheumatoid arthritis
P Siakka, A Kalikaki, K Pagonidis, P Sidiropoulos, H Kritikos, E Ganotakis, D Tsetis, DT Boumpas
Epstein–Barr virus load follow up in rheumatoid arthritis patients treated with TNF-α inhibitors
N Balandraud, JB Meynard, I Auger, H Sovran, B Mugnier, D Reviron, J Roudier, C Roudier
Prediagnosis radiological progression in rheumatoid arthritis: a novel tool to study the effects of early DMARD therapy
MC Wick, RJ Weiss, L Klareskog, RF van Vollenhoven
The effect of infliximab on skin lesions in a patient with scleroderma (CREST)
L De Rycke, D Baeten, F Van den Bosch, H Mielants, F De Keyser, EM Veys
Anti-TNF-α antibody Infliximab and glucocorticoids reduce serum vascular endothelial growth factor (VEGF) levels in patients with rheumatoid arthritis: a pilot study
J Strunk, E Heinemann, U Lange
Allogeneic bone marrow transplantation can suppress established and otherwise chronic collagen-induced arthritis after a nonmyeloablative conditioning regimen employing anti-CD40 ligand monoclonal antibody
R Flierman, L Morgan, L van Duivenvoorde, RRP de Vries, WE Fibbe, TJW Huizinga, REM Toes, JM van Laar
Cross-reaction between the major epitope of Ro60 protein (pep216–232) and a homologous peptide of Coxsackievirus 3C protease
EA Stathopoulou, JG Routsias, HA Stea, HM Moutsopoulos, AG Tzioufas
Aberrant expression of the co-chaperone HDJ2 in rheumatoid arthritis
A Zgaga-Griesz, S Haak, K Retzlaff, C Schick, R Rzepka, I Melchers
Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium
M Korotkova, M Westman, E af Klint, A-K Ulfgren, L Klareskog, P-J Jakobsson
Salivary gland epithelial cells (SGEC) express a novel alternate transcript of the B7.2 costimulatory molecule that lacks the CD28/CTLA4-binding IgV-like domain
EK Kapsogeorgou, HM Moutsopoulos, MN Manoussakis
Statins have no effect on collagen-induced arthritis in mice
G Palmer, V Chobaz, D Talabot, S Taylor, A So, C Gabay, N Busso
Serum MRP8/MRP14 as a biomarker for inflammation in autoimmune arthritis
L De Rycke, D Baeten, D Foell, E Kruithof, EM Veys, J Roth, F De Keyser
Three-dimensional power Doppler sonographic visualization of synovial vasculature: an 'in vivo' model to study angiogenesis in rheumatoid arthritis
J Strunk, K Strube, P Klingenberger, U Lange
A new approach to study angiogenesis in rheumatoid arthritis by power Doppler sonography and serum vascular endothelial growth factor level measurement
J Strunk, E Heinemann, U Lange
The role of a defective clearance in the pathogenesis of systemic lupus erythematosus
S Franz, US Gaipl, U Appelt, P Heyder, RE Voll, JR Kalden, M Herrmann
Clinical and serological study of 26 patients with anti-SL (Ki) autoantibodies
I Cavazzana, F Franceschini, C Vassalini, M Quinzanini, L Andreoli, R Cattaneo
Drug induced differential gene expression in normal and RA synovial fibroblasts cell lines
M Yahyawi, C Kaps, C Lübke, J Ringe, T Rohrlach, H Augst, G-R Burmester, T Häupl, M Sittinger