A triple-lumen, 18G, 16-cm-long central venous catheter (CVC) was placed into the right internal jugular vein in a 74-yr-old female undergoing elective annuloplasty of the mitral and tricuspid valves to treat severe regurgitation from mitral anterior leaflet prolapse and tricuspid annular dilatation. After uneventful surgery, simultaneous blood samples were drawn from the radial artery and distal lumen of the CVC for blood gas analysis. Surprisingly, central venous blood analysis showed high oxygen saturation (96%) and partial pressure of oxygen (PvO2 = 84 mmHg) similar to the sample taken from the arterial catheter (98%; PaO2 = 122 mmHg). The central venous pressure at the time of the blood draw was 9 mmHg. A postoperative chest radiograph showed the CVC in correct position with the tip of a catheter visible at the superior vena cava (SVC)-right atrial junction. Further blood sampling from the CVC showed a significant difference in oxygen saturation between samples from the proximal (64%) and distal CVC lumen (96%). Preoperative transthoracic and perioperative transoesophageal echocardiographic examination revealed no atrial septal defect or other obvious pathology explaining the left-to-right blood shunting. Although moderate dilatation of the right heart chambers was seen on echocardiography, it was considered non-specific and consistent with the known valvular pathology. Subsequent postoperative computed tomography angiography confirmed partial anomalous pulmonary venous drainage with two branches of the right upper pulmonary vein entering the SVC (Figure). The diagnosis warrants long-term follow-up to detect the possible development of severe pulmonary hypertension and right ventricular dysfunction that might be prevented by a surgical correction.