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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2023

Open Access 01-12-2023 | Arterial Occlusive Disease | Research

Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes

Authors: Shamsi Sadat Mosavi, Soghra Rabizadeh, Amirhossein Yadegar, Sara Seifouri, Fatemeh Mohammadi, Reihane Qahremani, Salome Sadat Salehi, Armin Rajab, Alireza Esteghamati, Manouchehr Nakhjavani

Published in: BMC Complementary Medicine and Therapies | Issue 1/2023

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Abstract

Background

Resveratrol and omega-3 have been shown to prevent atherosclerosis. However, histopathological changes and their comparison have not been studied well. This study investigated the therapeutic effects of resveratrol and omega-3 in experimental atherosclerosis of mice.

Methods

We divided sixty 6-week-old male C57BL/6 mice into six groups and followed for 10 weeks: (1) standard diet, (2) atherogenic diet, (3) atherogenic diet along with resveratrol from the start of the sixth week, (4) atherogenic diet along with omega-3 from the start of the sixth week, (5) standard diet along with resveratrol from the start of the sixth week, (6) standard diet along with omega-3 from the start of the sixth week.

Results

The mice fed on an atherogenic diet had a larger fat area and a thicker aortic wall thickness than mice fed on a standard diet. The use of omega-3 and resveratrol in the mice with an atherogenic diet resulted in a significantly reduced fat area (p-value = 0.003), and resveratrol had a significantly higher effect. Omega-3 or resveratrol induced a significant reduction in aortic wall thickness in mice on an atherogenic diet, and there was no significant difference between them. Among the mice with a standard diet, this study did not observe any significant changes in the fat area or the aortic wall thickness with the consumption of omega-3 or resveratrol.

Conclusions

Resveratrol and omega-3 had a regressive and therapeutic role in atherosclerosis, with a more significant effect in favor of resveratrol.
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Metadata
Title
Therapeutic effects of resveratrol and Omega-3 in mice atherosclerosis: focus on histopathological changes
Authors
Shamsi Sadat Mosavi
Soghra Rabizadeh
Amirhossein Yadegar
Sara Seifouri
Fatemeh Mohammadi
Reihane Qahremani
Salome Sadat Salehi
Armin Rajab
Alireza Esteghamati
Manouchehr Nakhjavani
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2023
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-023-03899-9

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