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Open Access 01-12-2017 | Review

ARLTS1 polymorphism is associated with an increased risk of familial cancer: evidence from a meta-analysis

Authors: Yan Jiang, Chen-Yang Zhao, Li-Chun Cheng, Bing Xu, Hui-Yi Lv

Published in: Hereditary Cancer in Clinical Practice | Issue 1/2017

Abstract

Adenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1(ARLTS1) might be associated with an increased risk of several types of familial cancers. However, previous studies have shown that cancer susceptibility is not completely consistent with ARLTS1 polymorphisms, and the precise mechanism remains unknown. Therefore, we conducted a meta-analysis of case-control studies by searching the PubMed, Embase, OVID, Science Direct and Chinese National Knowledge Infrastructure (CNKI) databases. In total, 12 studies met the inclusion criteria and were included in this meta-analysis. Statistical analyses were performed using STATA 11.0 software. Overall, the Cys148Arg T > C variant significantly increased cancer risk (CC vs. TT: OR = 1.27, 95% CI = 1.15–1.41, P < 0.05). The stratification indicated that the Cys148Arg variant is significantly associated with sporadic cancer (CC vs. TT: OR = 1.36, 95% CI = 1.18–1.55) and familial cancer (CC vs. TT: OR = 1.26, 95% CI = 1.12–1.43). Trp149Stop, Pro131Leu, Ser99Ser and Leu132Leu were not correlated with cancer susceptibility. Based on these results, we demonstrated that the ARLTS1 Cys148Arg polymorphism is associated with an increased risk of sporadic cancer and familial cancer, and there were no associations between the other four SNPs (i.e., Trp149Stop, Pro131Leu, Ser99Ser and Leu132Leu) and cancer risk.

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Title: ARLTS1 polymorphism is associated with an increased risk of familial cancer: evidence from a meta-analysis
Authors: Yan Jiang
Chen-Yang Zhao
Li-Chun Cheng
Bing Xu
Hui-Yi Lv
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Hereditary Cancer in Clinical Practice / Issue 1/2017
Electronic ISSN: 1897-4287
DOI: https://doi.org/10.1186/s13053-017-0068-7

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