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Knee Surgery, Sports Traumatology, Arthroscopy

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01-06-2013 | Experimental Study

Arguments for an increasing differentiation towards fibrocartilaginous components in midportion Achilles tendinopathy

Authors: A. Burssens, R. Forsyth, W. Bongaerts, M. Jagodzinski, N. Mahieu, M. Praet, J. Victor

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 6/2013

Abstract

Purpose

The objective of this study was to investigate the fibrocartilaginous differentiation occurring in midportion Achilles tendinopathy.

Methods

Tendon samples were retrospectively collected from 23 patients, who had undergone surgery for midportion Achilles tendinopathy resistant to conservative treatment. Based on histological scores, the biopts were subdivided into three categories: a light, moderate and severe histopathological stage. Throughout these stages, immunohistochemical staining was performed against biglycan, aggrecan and collagen type II, components characteristic for fibrocartilage. Staining of these components was evaluated using a semi-quantitative scoring method.

Results

The immunohistochemical scores of biglycan and aggrecan were statistically significant between the histopathological stages (P < 0.001). The immunohistochemical scores were positively correlated with the increasing histopathological stages [Spearman’s correlation coefficient = 0.93 for biglycan and 0.78 for aggrecan (P < 0.001)]. Staining for collagen type II remained negative throughout these stages.

Conclusion

Immunohistochemical staining of the fibrocartilaginous components biglycan and aggrecan showed a progressive increase, correlated with a further evolved histopathological stage. This observation gave arguments for an increased differentiation towards fibrocartilaginous components at protein level in midportion Achilles tendinopathy.

Level of evidence

III.

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Title: Arguments for an increasing differentiation towards fibrocartilaginous components in midportion Achilles tendinopathy
Authors: A. Burssens
R. Forsyth
W. Bongaerts
M. Jagodzinski
N. Mahieu
M. Praet
J. Victor
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 6/2013
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-012-2203-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Arguments for an increasing differentiation towards fibrocartilaginous components in midportion Achilles tendinopathy

Abstract

Purpose

Methods

Results

Conclusion

Level of evidence

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Level of evidence

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