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01-03-2009 | Nephrology - Review

Are children with congenital solitary kidney at risk for lifelong complications? A lack of prediction demands caution

Authors: Marco Zaffanello, Milena Brugnara, Michele Zuffante, Massimo Franchini, Vassilios Fanos

Published in: International Urology and Nephrology | Issue 1/2009

Abstract

Congenital solitary functioning kidney (CSFK), which develops during embryo or fetal life, means having either one anatomical/functional kidney or two kidneys, one of which does not function. Similar anomalies have been seen in every other organ system and involve a large percentage of newborns. Still, prediction of long-term renal morbidity in congenital functioning solitary kidney is complicated by the great variability of renal and extrarenal phenotypes. Classification of different solitary renal types, whether or not a syndrome, may help to predict the possible evolution of complications; this may be hindered, however, by the gene-environment role during kidney development. Since the risk of renal failure in children with CSFK depends on several variables, it is always advisable to have a precise clinical description at diagnosis. This condition often requires long-term follow-up into adulthood.

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Title: Are children with congenital solitary kidney at risk for lifelong complications? A lack of prediction demands caution
Authors: Marco Zaffanello
Milena Brugnara
Michele Zuffante
Massimo Franchini
Vassilios Fanos
Publication date: 01-03-2009
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 1/2009
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-008-9437-5

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