Skip to main content
Top
Published in: European Spine Journal 4/2012

01-06-2012 | Case Report

Arachnoid ossificans containing metaplastic hematopoietic marrow resulting in diffuse thoracic intrathecal cysts and severe myelopathy

Authors: Joshua Abrams, Gordon Li, Stefan A. Mindea, Claudia M. Haynes, Ivan Cheng

Published in: European Spine Journal | Special Issue 4/2012

Login to get access

Abstract

Objective

To present a rare case of multiple compressive thoracic intradural cysts with pathologic arachnoid ossification, review the literature and present the surgical options.

Summary of background data

Few reports have identified the existence of arachnoid calcifications and intrathecal cysts causing progressive myelopathy. The literature regarding each of these pathologies is limited to case reports. Their clinical significance is not well studied, although known to cause neurologic sequelae.

Methods

An 81-year-old female clinically presents with rapidly progressive myelopathy. Pre-operative magnetic resonance imaging identified multiple compressive thoracic intrathecal cysts. Surgical exploration and decompression of these cysts identified calcified plaques within the arachnoid. Histopathologic examination revealed fibrocalcific tissue undergoing ossification with bone marrow elements.

Results

Due to progressive myelopathy, the thoracic cysts were decompressed and calcified plaques were excised, once identified intra-operatively.

Conclusions

On last examination, the patient’s neurologic status had not improved, but had stabilized. The rate of neurologic improvement from excision and decompression is variable, but it may still be warranted in the face of progressive neurologic deficits.
Literature
1.
go back to reference Revilla TY, Ramos A, Gonzalez P, Alday R, Milla’n JM (1999) Arachnoiditis ossificans. Diagnosis with helical computed tomography. Clin Imaging 23:1–4PubMedCrossRef Revilla TY, Ramos A, Gonzalez P, Alday R, Milla’n JM (1999) Arachnoiditis ossificans. Diagnosis with helical computed tomography. Clin Imaging 23:1–4PubMedCrossRef
2.
go back to reference Kitagawa H, Kanamori M, Tatezaki S, Itoh T, Tsuji H (1990) Multiple spinal ossified arachnoiditis. A case report. Spine 15:1236–1238PubMedCrossRef Kitagawa H, Kanamori M, Tatezaki S, Itoh T, Tsuji H (1990) Multiple spinal ossified arachnoiditis. A case report. Spine 15:1236–1238PubMedCrossRef
3.
go back to reference Whittle IR, Dorsch NW, Segelov JN (1982) Symptomatic arachnoiditis ossificans. Report of two cases. Acta Neurochir 65:207–216CrossRef Whittle IR, Dorsch NW, Segelov JN (1982) Symptomatic arachnoiditis ossificans. Report of two cases. Acta Neurochir 65:207–216CrossRef
4.
go back to reference Testworth KD, Ferguson RL (1986) Arachnoiditis ossificans of the cauda equine: a case report. Spine 11:765–766CrossRef Testworth KD, Ferguson RL (1986) Arachnoiditis ossificans of the cauda equine: a case report. Spine 11:765–766CrossRef
5.
go back to reference Sakai T, Sairyo K, Kashima M, Kosaka H, Katoh S, Yasui N (2009) Diffuse arachnoid ossification and multiple arachnoid cysts presenting with progressive thoracic myelopathy. Skeletal Radiol 39:299–304PubMedCrossRef Sakai T, Sairyo K, Kashima M, Kosaka H, Katoh S, Yasui N (2009) Diffuse arachnoid ossification and multiple arachnoid cysts presenting with progressive thoracic myelopathy. Skeletal Radiol 39:299–304PubMedCrossRef
6.
go back to reference Papavlasopoulos F, Stranjalis G, Kouyialis AT et al (2007) Arachnoiditis ossificans with progressive syringomyelia and spinal arachnoid cyst. J Clin Neurosci 14:572–576PubMedCrossRef Papavlasopoulos F, Stranjalis G, Kouyialis AT et al (2007) Arachnoiditis ossificans with progressive syringomyelia and spinal arachnoid cyst. J Clin Neurosci 14:572–576PubMedCrossRef
7.
go back to reference Kaufman AB, Dunsmore RH (1971) Clinicopathological considerations in spinal meningeal calcifications and ossification. Neurology 21:1243–1248PubMedCrossRef Kaufman AB, Dunsmore RH (1971) Clinicopathological considerations in spinal meningeal calcifications and ossification. Neurology 21:1243–1248PubMedCrossRef
8.
go back to reference Jaspan T, Preston BJ, Mulholland RC, Webb JK (1990) The CT appearances of archnoiditis ossificans. Spine 15:148–151PubMedCrossRef Jaspan T, Preston BJ, Mulholland RC, Webb JK (1990) The CT appearances of archnoiditis ossificans. Spine 15:148–151PubMedCrossRef
9.
go back to reference Perry NG, Lorentz I, Sun Soo Y (1996) Arachnoiditis ossificans of the cauda equina demonstrated on computed tomography scanogram. A case report. Spine 21:2504–2507CrossRef Perry NG, Lorentz I, Sun Soo Y (1996) Arachnoiditis ossificans of the cauda equina demonstrated on computed tomography scanogram. A case report. Spine 21:2504–2507CrossRef
10.
go back to reference Toribatake Y, Baba h, Maezawa Y, Umeda S, Tomita K (1995) Symptomatic arachnoiditis ossificans of the thoracic spine. Case report. Paraplegia 33:224–227PubMedCrossRef Toribatake Y, Baba h, Maezawa Y, Umeda S, Tomita K (1995) Symptomatic arachnoiditis ossificans of the thoracic spine. Case report. Paraplegia 33:224–227PubMedCrossRef
11.
go back to reference Van Paesschen W, Van Den Kerchove M, Appel B, Klaes R, Neeens I, Lowenthal A (1990) Arachnoiditis ossificans with arachnoid cyst after cranial tuberculous meningitis. Neurology 40:714–716PubMedCrossRef Van Paesschen W, Van Den Kerchove M, Appel B, Klaes R, Neeens I, Lowenthal A (1990) Arachnoiditis ossificans with arachnoid cyst after cranial tuberculous meningitis. Neurology 40:714–716PubMedCrossRef
12.
14.
go back to reference Collins DH, Curran RC (1959) Pathological calcification and osseous metaplasia in man. In: Modern trends in pathology, 2nd edn. Butterworth, London Collins DH, Curran RC (1959) Pathological calcification and osseous metaplasia in man. In: Modern trends in pathology, 2nd edn. Butterworth, London
16.
17.
go back to reference Slavin KV, Nixon RR, Nesbit GM et al (1999) Extensive arachnoid ossification with associated syringomyelia presenting as thoracic myelopathy. Case report and review of the literature. Neurosurg Focus 6:E11CrossRef Slavin KV, Nixon RR, Nesbit GM et al (1999) Extensive arachnoid ossification with associated syringomyelia presenting as thoracic myelopathy. Case report and review of the literature. Neurosurg Focus 6:E11CrossRef
18.
go back to reference Slager UT (1960) Arachnoiditis ossificans Report of a case and review of the subject. Arch Pathol 70:322–327PubMed Slager UT (1960) Arachnoiditis ossificans Report of a case and review of the subject. Arch Pathol 70:322–327PubMed
19.
20.
go back to reference Tagaki T, Nomura T, Toh E, Watanabe M, Mochida J (2006) Multiple extradural arachnoid cysts at the spinal cord and cauda equina levels in the young. Spinal Cord 44:59–62CrossRef Tagaki T, Nomura T, Toh E, Watanabe M, Mochida J (2006) Multiple extradural arachnoid cysts at the spinal cord and cauda equina levels in the young. Spinal Cord 44:59–62CrossRef
21.
go back to reference Kahler RJ, Knuckey NW, Davis S (2000) Arachnoiditis ossificans and syringomyelia: a unique case report. J Clin Neurosci 7(1):66–68PubMedCrossRef Kahler RJ, Knuckey NW, Davis S (2000) Arachnoiditis ossificans and syringomyelia: a unique case report. J Clin Neurosci 7(1):66–68PubMedCrossRef
22.
go back to reference Hatashita S, Kondo A, Shimizu T, Kurosu A, Ueno H (2001) Spinal extradural arachnoid cyst. Neurol Med Chir (Tokyo) 41:318–321CrossRef Hatashita S, Kondo A, Shimizu T, Kurosu A, Ueno H (2001) Spinal extradural arachnoid cyst. Neurol Med Chir (Tokyo) 41:318–321CrossRef
23.
go back to reference Andrews BT, Weinstein PR, Rosenblum ML et al (1988) Intradural arachnoid cysts of the spinal canal associated with intramedullary cysts. J Neurosurg 68:544–549PubMedCrossRef Andrews BT, Weinstein PR, Rosenblum ML et al (1988) Intradural arachnoid cysts of the spinal canal associated with intramedullary cysts. J Neurosurg 68:544–549PubMedCrossRef
24.
go back to reference Kendall BE, Valentine AR, Keis B (1982) Spinal arachnoid cysts: clinical and radiological correlation with prognosis. Neuroradiology 22:225–234PubMedCrossRef Kendall BE, Valentine AR, Keis B (1982) Spinal arachnoid cysts: clinical and radiological correlation with prognosis. Neuroradiology 22:225–234PubMedCrossRef
25.
go back to reference McCormick P, Stein B (1990) Arachnoid cysts. Neurosurg Clin North Am 695:695–696 McCormick P, Stein B (1990) Arachnoid cysts. Neurosurg Clin North Am 695:695–696
Metadata
Title
Arachnoid ossificans containing metaplastic hematopoietic marrow resulting in diffuse thoracic intrathecal cysts and severe myelopathy
Authors
Joshua Abrams
Gordon Li
Stefan A. Mindea
Claudia M. Haynes
Ivan Cheng
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
European Spine Journal / Issue Special Issue 4/2012
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-011-2005-1

Other articles of this Special Issue 4/2012

European Spine Journal 4/2012 Go to the issue