Arachnoid cyst: a further anomaly associated with Kallmann syndrome?

Excerpt

In their report, Massimi et al. described an 11-year-old male case with the typical characteristics of Kallmann syndrome (KS) associated with a middle fossa arachnoid cyst (AC). Hence, their case did not represent a genetically proven KS, but the association of hypogonadotropic hypogonadism with anosmia and bilateral agenesia of the olfactory bulb/tract complex strongly suggests it. The case presented by Massimi et al. is the fifth case reported in the literature in which KS has been found to be associated with AC. Up to date, various developmental abnormalities of the nervous system have been described to accompany KS. Among those, midline cranial abnormalities, holoprosencephaly-hypopituitarism complex, unilateral hearing loss, color blindness, agenesis of the corpus callosum, unilateral coloboma of the optic nerve, and oculomotor anomalies, such as ptosis and nystagmus, have been reported [1, 2]. …