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International Ophthalmology

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01-12-2024 | Review

Aqueous humor protein markers in myopia: a review

Authors: Jiechao Shao, Zongchan Zhang, Xuecheng Cai, Ye Shen, Jianping Tong

Published in: International Ophthalmology | Issue 1/2024

Abstract

Purpose

Myopia is one of the most common forms of refractive error. Most myopia manifests itself as a relative growth of the eye axis, resulting in a state in which light is projected in front of the retina after being refracted by the refractive system of the eyeball. So far, the specific pathogenesis of myopia is still not well explained, through the results of animal experiments, researchers have proposed various possible scenarios, but all these are based on animal models, and there may still be a certain gap with the mechanism of true myopia in humans. The most readily available in clinical work is aqueous humor obtained during cataract surgery, for which we reviewed these studies of aqueous humor samples from myopic patients.

Methods

A systematic literature search was done on PubMed using key words including “myopia,” “aqueous humor,” and “protein.”

Results

The results of existing aqueous humor studies have shown that the difference in substances in the aqueous humor of myopia is related to the degradation of the scleral matrix, chronic inflammation of the eye, pro-fibrosis, blood vessel production, and inhibition. There may be more than one reason associated with myopia progression.

Conclusion

The specific mechanism of myopia has not been fully elucidated. Therefore, the means of preventing and treating myopia should focus on inhibiting the degradation of the scleral matrix, promoting the proliferation of scleral collagen fibers, and alleviating chronic inflammation of the eyes. Further research into myopic aqueous humor may provide us with new insights.

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Title: Aqueous humor protein markers in myopia: a review
Authors: Jiechao Shao
Zongchan Zhang
Xuecheng Cai
Ye Shen
Jianping Tong
Publication date: 01-12-2024
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-02942-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Aqueous humor protein markers in myopia: a review

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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