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BMC Ophthalmology
Published in: BMC Ophthalmology 1/2013

Open Access 01-12-2013 | Research article

Aqueous flare and inflammatory factors in macular edema with central retinal vein occlusion: a case series

Authors: Hidetaka Noma, Tatsuya Mimura, Maria Tatsugawa, Katsunori Shimada

Published in: BMC Ophthalmology | Issue 1/2013

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Abstract

Background

The association of inflammatory factors and the aqueous flare value with macular edema in central retinal vein occlusion (CRVO) patients remains unclear. We investigated the relations between the aqueous flare value and vitreous levels of vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and interleukin-6 (IL-6) in patients with CRVO and macular edema or patients with idiopathic macular hole (MH).

Methods

In 38 patients who underwent unilateral vitrectomy (21 CRVO patients and 17 MH patients), vitreous samples were obtained during vitrectomy to measure VEGF, sICAM-1, and IL-6. Retinal ischemia was evaluated from capillary non-perfusion on fluorescein angiography, and the CRVO patients were classified into nonischemic or ischemic groups. Aqueous flare values were measured with a laser flare meter and macular edema was examined by optical coherence tomography.

Results

The median aqueous flare value increased significantly across the three groups (MH group < nonischemic CRVO group < ischemic CRVO group). There was a significant correlation between the flare value and vitreous levels of VEGF, sICAM-1, and IL-6 in the CRVO group. The flare value was also significantly correlated with the severity of macular edema in the CRVO group.

Conclusions

Inflammation and/or ischemia may increase vascular permeability and disrupt the blood-aqueous barrier by increasing levels of inflammatory factors in patients with CRVO and macular edema.
Appendix
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Metadata
Title
Aqueous flare and inflammatory factors in macular edema with central retinal vein occlusion: a case series
Authors
Hidetaka Noma
Tatsuya Mimura
Maria Tatsugawa
Katsunori Shimada
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Ophthalmology / Issue 1/2013
Electronic ISSN: 1471-2415
DOI
https://doi.org/10.1186/1471-2415-13-78

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