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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2014

Open Access 01-12-2014 | Research article

Aqueous extract of dioscorea opposita thunb. normalizes the hypertension in 2K1C hypertensive rats

Authors: Nurmuhammat Amat, Raziya Amat, Sajida Abdureyim, Parida Hoxur, Zulpiya Osman, Dolkun Mamut, Anake Kijjoa

Published in: BMC Complementary Medicine and Therapies | Issue 1/2014

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Abstract

Background

Dioscorea opposita Thunb. (Huai Shan Yao, DOT), a common staple food in China, has been used for more than 2000 years in traditional Chinese medicine (TCM) to treat different systemic diseases including hypertension. The objective of this study was to investigate the possible antihypertensive effects of the aqueous extract of (DOT) in renovascular hypertensive rats as well as the mechanism in reducing blood pressure.

Methods

The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. Rats with captopril, low-dose DOT and high-dose DOT treated 2K1C groups for 6 weeks. The blood pressure, cardiac mass index (heart weight/body weight), plasma level of angiotensin-II (Ang-II), endothelin-1(ET-1), superoxide dismutase (SOD) and malondialdehyde (MDA) were evaluated.

Results

DOT significantly reduced mean systolic and diastolic blood pressure after treatment. DOT also significantly increased plasma SOD activity but decreased plasma MDA concentration. Renal function was improved with captopril and DOT. DOT reduced plasma Ang-II activity and plasma ET concentration. They couldalso significantly reduce the left ventricular hypertrophy and cardiac mass index.

Conclusions

Our results suggest that DOT may have an antihypertensive effect on hypertension by inhibit ET-converting enzyme and antioxidant activity, which warrant further exploration.
Appendix
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Metadata
Title
Aqueous extract of dioscorea opposita thunb. normalizes the hypertension in 2K1C hypertensive rats
Authors
Nurmuhammat Amat
Raziya Amat
Sajida Abdureyim
Parida Hoxur
Zulpiya Osman
Dolkun Mamut
Anake Kijjoa
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2014
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/1472-6882-14-36

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