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Open Access 01-12-2010 | Review

Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus

Authors: Brian K Owler, Tom Pitham, Dongwei Wang

Published in: Fluids and Barriers of the CNS | Issue 1/2010

Abstract

The discovery of a family of membrane water channel proteins called aquaporins, and the finding that aquaporin 1 was located in the choroid plexus, has prompted interest in the role of aquaporins in cerebrospinal fluid (CSF) production and consequently hydrocephalus. While the role of aquaporin 1 in choroidal CSF production has been demonstrated, the relevance of aquaporin 1 to the pathophysiology of hydrocephalus remains debated. This has been further hampered by the lack of a non-toxic specific pharmacological blocking agent for aquaporin 1. In recent times aquaporin 4, the most abundant aquaporin within the brain itself, which has also been shown to have a role in brain water physiology and relevance to brain oedema in trauma and tumours, has become an alternative focus of attention for hydrocephalus research. This review summarises current knowledge and concepts in relation to aquaporins, specifically aquaporin 1 and 4, and hydrocephalus. It also examines the relevance of aquaporins as potential therapeutic targets in hydrocephalus and other CSF circulation disorders.

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Title: Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus
Authors: Brian K Owler
Tom Pitham
Dongwei Wang
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Fluids and Barriers of the CNS / Issue 1/2010
Electronic ISSN: 2045-8118
DOI: https://doi.org/10.1186/1743-8454-7-15

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Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain

Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid

Congenital myelomeningocele - do we have to change our management?

Choroid plexus failure in the Kearns-Sayre syndrome

Elevated CSF outflow resistance associated with impaired lymphatic CSF absorption in a rat model of kaolin-induced communicating hydrocephalus

Minocycline inhibits glial proliferation in the H-Tx rat model of congenital hydrocephalus