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Pharmaceutical Medicine

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01-01-2008 | Current Opinion

Applications of Binding Kinetics to Drug Discovery

Translation of Binding Mechanisms to Clinically Differentiated Therapeutic Responses

Author: Dr David C. Swinney

Published in: Pharmaceutical Medicine | Issue 1/2008

Abstract

The therapeutic response of a drug is initiated by binding to a physiological target. The efficacy, tolerability and therapeutic index of the drug will be influenced by how efficiently the binding is coupled to physiology. The influence of coupling efficiency on dose-response relationships is determined by drug binding kinetics and drug-induced conformational changes to the physiological target. Binding kinetics determine the affinity of a drug to its target and can impact the coupling efficiency of the drug by affecting the state of equilibrium. The end result may be greater efficacy (exemplified by the angiotensin II receptor 1 antagonists), longer duration of response (muscarinic receptor antagonists), differentiation of therapeutic indications (NSAIDs and ion channel antagonists) and/or greater tolerability (atypical antipsychotics, N-methyl-D-aspartate [NMDA] receptor antagonists, NSAIDs and selective estrogen receptor modulators).

The role of binding kinetics and mechanism in shaping the therapeutic utility of a drug is not captured in the current definition of a successful drug target. This article proposes that a mechanistic definition of a drug target that includes both the macromolecular protein and binding mechanism will help capture the value of discovering a binding mechanism that effectively translates drug binding to a therapeutically useful response. These examples demonstrate that binding kinetics and mechanisms help shape the clinical outcomes that are important to patients and clinicians, namely efficacy, safety, duration of action and therapeutic differentiation.

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Title: Applications of Binding Kinetics to Drug Discovery
Translation of Binding Mechanisms to Clinically Differentiated Therapeutic Responses
Author: Dr David C. Swinney
Publication date: 01-01-2008
Publisher: Springer International Publishing
Published in: Pharmaceutical Medicine / Issue 1/2008
Print ISSN: 1178-2595
Electronic ISSN: 1179-1993
DOI: https://doi.org/10.1007/BF03256679

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Applications of Binding Kinetics to Drug Discovery

Translation of Binding Mechanisms to Clinically Differentiated Therapeutic Responses

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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