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BMC Proceedings
Published in: BMC Proceedings 7/2009

Open Access 01-12-2009 | Proceedings

Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data

Published in: BMC Proceedings | Special Issue 7/2009

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Abstract

We explored five sex-specific quality control filters in North American Rheumatoid Arthritis Consortium's Illumina 550 k datasets. Three X chromosome and three autosomal single-nucleotide polymorphisms flagged by sex quality control filters were missed by filters of call rate at 95% and Hardy-Weinberg equilibrium at 10-6. We applied a subset of these sex-specific quality control filters to eight chromosomes in the Framingham Heart Study samples genotyped by Affymetrix 500 k SNP arrays, and identified another two single-nucleotide polymorphisms that failed to be picked up by the above global filters.
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Metadata
Title
Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data
Publication date
01-12-2009
Published in
BMC Proceedings / Issue Special Issue 7/2009
Electronic ISSN: 1753-6561
DOI
https://doi.org/10.1186/1753-6561-3-S7-S57

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