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Published in: Italian Journal of Pediatrics 1/2017

Open Access 01-12-2017 | Review

Apparent Life-Threatening Events (ALTE): Italian guidelines

Authors: Raffaele Piumelli, Riccardo Davanzo, Niccolò Nassi, Silvia Salvatore, Cinzia Arzilli, Marta Peruzzi, Massimo Agosti, Antonella Palmieri, Maria Giovanna Paglietti, Luana Nosetti, Raffaele Pomo, Francesco De Luca, Alessandro Rimini, Salvatore De Masi, Simona Costabel, Valeria Cavarretta, Anna Cremante, Fabio Cardinale, Renato Cutrera

Published in: Italian Journal of Pediatrics | Issue 1/2017

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Abstract

Five years after the first edition, we have revised and updated the guidelines, re-examining the queries and relative recommendations, expanding the issues addressed with the introduction of a new entity, recently proposed by the American Academy of Pediatrics: BRUE, an acronym for Brief Resolved Unexplained Events. In this manuscript we will use the term BRUE only to refer to mild, idiopathic cases rather than simply replace the acronym ALTE per se.
In our guidelines the acronym ALTE is used for severe cases that are unexplainable after the first and second level examinations.
Although the term ALTE can be used to describe the common symptoms at the onset, whenever the aetiology is ascertained, the final diagnosis may be better specified as seizures, gastroesophageal reflux, infection, arrhythmia, etc. Lastly, we have addressed the emerging problem of the so-called Sudden Unexpected Postnatal Collapse (SUPC), that might be considered as a severe ALTE occurring in the first week of life.
Literature
3.
go back to reference American Academy of Pediatrics. National Institutes of Health consensus development conference on infantile apnea and home monitoring, Sept 29 to Oct 1, 1986. Pediatrics. 1987;79:292–9. American Academy of Pediatrics. National Institutes of Health consensus development conference on infantile apnea and home monitoring, Sept 29 to Oct 1, 1986. Pediatrics. 1987;79:292–9.
4.
go back to reference Crowcroft NS, Zambon M, Harrison TG, Mok Q, Heath P, Miller E. Respiratory syncytial virus infection in infants admitted to paediatric intensive care units in London, and in their families. Eur J Pediatr. 2008;167:395–9.PubMedCrossRef Crowcroft NS, Zambon M, Harrison TG, Mok Q, Heath P, Miller E. Respiratory syncytial virus infection in infants admitted to paediatric intensive care units in London, and in their families. Eur J Pediatr. 2008;167:395–9.PubMedCrossRef
5.
go back to reference Angle B, Burton BK. Risk of sudden death and acute life-threatening events in patients with glutaric acidemia type II. Mol Genet Metab. 2008;93:36–9. Angle B, Burton BK. Risk of sudden death and acute life-threatening events in patients with glutaric acidemia type II. Mol Genet Metab. 2008;93:36–9.
6.
go back to reference Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, et al. Brief resolved unexplained events (formerly apparent life-threatening events) and evaluation of lower-risk infants. Pediatrics. 2016; 10.1542/peds.2016-1488. Tieder JS, Bonkowsky JL, Etzel RA, Franklin WH, Gremse DA, Herman B, et al. Brief resolved unexplained events (formerly apparent life-threatening events) and evaluation of lower-risk infants. Pediatrics. 2016; 10.​1542/​peds.​2016-1488.
7.
go back to reference Damus K, Pakter J, Krongrad E. Posnatal medical and epidemiological risk factors for the sudden infant death syndrome. In: Harper R, Hoffman H, editors. Sudden infant death syndrome: risk factors and basic mechanisms. New York: PMA Publishing; 1984. p. 187. Damus K, Pakter J, Krongrad E. Posnatal medical and epidemiological risk factors for the sudden infant death syndrome. In: Harper R, Hoffman H, editors. Sudden infant death syndrome: risk factors and basic mechanisms. New York: PMA Publishing; 1984. p. 187.
9.
go back to reference Samuels MP. Apparent life threatening events: pathogenesis and management. In: Loughlin GM, Carrol JL, Marcus CL editors. Sleep and Breathing in Children. A Developmental Approach. New York: Marcel Dekker; 2000. p. 423–36. Samuels MP. Apparent life threatening events: pathogenesis and management. In: Loughlin GM, Carrol JL, Marcus CL editors. Sleep and Breathing in Children. A Developmental Approach. New York: Marcel Dekker; 2000. p. 423–36.
10.
go back to reference Mitchell EA, Thompson JMD. Parental reported apnoea, admissions to hospital and sudden infant death syndrome. Acta Paediatr. 2001;90:417–22.PubMedCrossRef Mitchell EA, Thompson JMD. Parental reported apnoea, admissions to hospital and sudden infant death syndrome. Acta Paediatr. 2001;90:417–22.PubMedCrossRef
11.
go back to reference Kiechl-Kohlendorfer U, Hof D, Peglow UP, Traweger-Ravanelli B, Kiechl S. Epidemiology of apparent life threatening events. Arch Dis Child. 2005;90:297–300.PubMedCrossRef Kiechl-Kohlendorfer U, Hof D, Peglow UP, Traweger-Ravanelli B, Kiechl S. Epidemiology of apparent life threatening events. Arch Dis Child. 2005;90:297–300.PubMedCrossRef
12.
go back to reference Semmekrot BA, Van Sleuwen BE, Engelberts AC, Joosten KF, Mulder JC, Liem KD, et al. Surveillance study of apparent life-threatening events (ALTE) in the Netherlands. Eur J Pediatr. 2010;169:229.PubMedCrossRef Semmekrot BA, Van Sleuwen BE, Engelberts AC, Joosten KF, Mulder JC, Liem KD, et al. Surveillance study of apparent life-threatening events (ALTE) in the Netherlands. Eur J Pediatr. 2010;169:229.PubMedCrossRef
13.
go back to reference Fu LY, Moon RY. Apparent life-threatening events (ALTEs) and the role of home monitors. Pediatr Rev. 2007;28:203.PubMedCrossRef Fu LY, Moon RY. Apparent life-threatening events (ALTEs) and the role of home monitors. Pediatr Rev. 2007;28:203.PubMedCrossRef
14.
go back to reference Kahn A. Recommended clinical evaluation of infants with an apparent life-threatening event. Consensus document of the European Society for the Study and Prevention of infant death, 2003. Eur J Pediatr. 2004;163:108–15.PubMedCrossRef Kahn A. Recommended clinical evaluation of infants with an apparent life-threatening event. Consensus document of the European Society for the Study and Prevention of infant death, 2003. Eur J Pediatr. 2004;163:108–15.PubMedCrossRef
16.
go back to reference Wijers MM, Semmekrot BA, de Beer HJ, Engelberts AC. Multidisciplinary guidelines for'Apparent life threatening event'(ALTE). Ned Tijdschr Geneeskd. 2009;153:590. Wijers MM, Semmekrot BA, de Beer HJ, Engelberts AC. Multidisciplinary guidelines for'Apparent life threatening event'(ALTE). Ned Tijdschr Geneeskd. 2009;153:590.
17.
go back to reference Tieder JS, Cowan CA, Garrison MM, Christakis DA. Variation in inpatient resource utilization and management of apparent life-threatening events. J Pediatr. 2008;152:629–35.PubMedCrossRef Tieder JS, Cowan CA, Garrison MM, Christakis DA. Variation in inpatient resource utilization and management of apparent life-threatening events. J Pediatr. 2008;152:629–35.PubMedCrossRef
18.
go back to reference Sahewalla R, Gupta D, Kamat D. Apparent life-threatening events: an overview. Clin Pediatr. 2016;55:5–9.CrossRef Sahewalla R, Gupta D, Kamat D. Apparent life-threatening events: an overview. Clin Pediatr. 2016;55:5–9.CrossRef
19.
go back to reference Aminiahidashti H. Infantile apparent life-threatening events, an educational review. Emerq (Tehran). 2015;3:8. Aminiahidashti H. Infantile apparent life-threatening events, an educational review. Emerq (Tehran). 2015;3:8.
20.
go back to reference Mittal MK, Sun G, Baren JM. A clinical decision rule to identify infants with apparent life-threatening event who can be safely discharged from the emergency department. Pediatr Emerg Care. 2012;28:599–605.PubMedCrossRef Mittal MK, Sun G, Baren JM. A clinical decision rule to identify infants with apparent life-threatening event who can be safely discharged from the emergency department. Pediatr Emerg Care. 2012;28:599–605.PubMedCrossRef
21.
go back to reference Arad-Cohen N, Cohen A, Tirosh E. The relationship between gastroesophageal reflux and apnea in infants. J Pediatr. 2000;137:321–6.PubMedCrossRef Arad-Cohen N, Cohen A, Tirosh E. The relationship between gastroesophageal reflux and apnea in infants. J Pediatr. 2000;137:321–6.PubMedCrossRef
22.
go back to reference Ing AJ, Ngu MC, Breslin AB. Obstructive sleep apnea and gastroesophageal reflux. Am J Med. 2000;108:120–5.CrossRef Ing AJ, Ngu MC, Breslin AB. Obstructive sleep apnea and gastroesophageal reflux. Am J Med. 2000;108:120–5.CrossRef
24.
go back to reference Mousa H, Woodley FW, Metheney M, Hayes J. Testing the association between gastroesophageal reflux and apnea in infants. J Pediatr Gastroenterol Nutr. 2005;41:169–77.PubMedCrossRef Mousa H, Woodley FW, Metheney M, Hayes J. Testing the association between gastroesophageal reflux and apnea in infants. J Pediatr Gastroenterol Nutr. 2005;41:169–77.PubMedCrossRef
25.
go back to reference Wenzl TG, Schenke S, Peschgens T, Silny J, Heimann G, Skopnik H. Association of apnea and nonacid gastroesophageal reflux in infants: investigations with the intraluminal impedance technique. Pediatr Pulmonol. 2001;31:144–9.PubMedCrossRef Wenzl TG, Schenke S, Peschgens T, Silny J, Heimann G, Skopnik H. Association of apnea and nonacid gastroesophageal reflux in infants: investigations with the intraluminal impedance technique. Pediatr Pulmonol. 2001;31:144–9.PubMedCrossRef
26.
go back to reference Zama D, Spizzichino M, Aceti A, Mariani E, Capretti MG, Galletti S, et al. The frequency of apneas in very preterm infants is increased after non-acid gastro-esophageal reflux. J Neurogastroenterol Motil. 2011; 10.1111/j.1365-2982.2010.01650. Zama D, Spizzichino M, Aceti A, Mariani E, Capretti MG, Galletti S, et al. The frequency of apneas in very preterm infants is increased after non-acid gastro-esophageal reflux. J Neurogastroenterol Motil. 2011; 10.​1111/​j.​1365-2982.​2010.​01650.
27.
go back to reference Blasco-Alonso J, Yun-Castilla C, Girón-Fernández-Crehuet F. Esophageal multichannel intraluminal impedance and pH testing in the study of apparent life threatening episode incidents in infants. Rev Esp Enferm Dig. 2014;106:159–64.PubMed Blasco-Alonso J, Yun-Castilla C, Girón-Fernández-Crehuet F. Esophageal multichannel intraluminal impedance and pH testing in the study of apparent life threatening episode incidents in infants. Rev Esp Enferm Dig. 2014;106:159–64.PubMed
28.
go back to reference Hasenstab KA, Jadcherla SR. Respiratory events in infants presenting with apparent life threatening events: is there an explanation from esophageal motility? J Pediatr. 2014;165:250–5.PubMedPubMedCentralCrossRef Hasenstab KA, Jadcherla SR. Respiratory events in infants presenting with apparent life threatening events: is there an explanation from esophageal motility? J Pediatr. 2014;165:250–5.PubMedPubMedCentralCrossRef
29.
go back to reference Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall E, Liptak G, Mazur L, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the north American Society for Pediatric Gastroenterology, Hepatology, and nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009;49:498–547.PubMedCrossRef Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall E, Liptak G, Mazur L, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the north American Society for Pediatric Gastroenterology, Hepatology, and nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009;49:498–547.PubMedCrossRef
30.
go back to reference Smits MJ, Wijk MP, Langendam MW, Benninga MA, Tabbers MM. Association between gastroesophageal reflux and pathologic apneas in infants: a systematic review. Neurogastroenterol Motil. 2014;26:1527–38.PubMedCrossRef Smits MJ, Wijk MP, Langendam MW, Benninga MA, Tabbers MM. Association between gastroesophageal reflux and pathologic apneas in infants: a systematic review. Neurogastroenterol Motil. 2014;26:1527–38.PubMedCrossRef
31.
go back to reference Tieder JS, Altman RL, Bonkowsky JL, Brand DA, Claudius I, Cunningham DJ, et al. Management of apparent life-threatening events in infants: a systematic review. J Pediatr. 2013;163:94–9.PubMedCrossRef Tieder JS, Altman RL, Bonkowsky JL, Brand DA, Claudius I, Cunningham DJ, et al. Management of apparent life-threatening events in infants: a systematic review. J Pediatr. 2013;163:94–9.PubMedCrossRef
32.
go back to reference Vandenplas Y, Salvatore S, Devreker T, Hauser B. Gastro-oesophageal reflux disease: oesophageal impedance versus pH monitoring. Acta Paediatr. 2007;96:956–62.PubMedCrossRef Vandenplas Y, Salvatore S, Devreker T, Hauser B. Gastro-oesophageal reflux disease: oesophageal impedance versus pH monitoring. Acta Paediatr. 2007;96:956–62.PubMedCrossRef
33.
go back to reference Wenzl TG, Benninga MA, Loots CM, Salvatore S, Vandenplas Y, ESPGHAN EURo-PIG Working Group. Indications, methodology, and interpretation of combined esophageal impedance-pH monitoring in children: ESPGHAN EURO-PIG standard protocol. J Pediatr Gastroenterol Nutr. 2012;55:230–4.PubMedCrossRef Wenzl TG, Benninga MA, Loots CM, Salvatore S, Vandenplas Y, ESPGHAN EURo-PIG Working Group. Indications, methodology, and interpretation of combined esophageal impedance-pH monitoring in children: ESPGHAN EURO-PIG standard protocol. J Pediatr Gastroenterol Nutr. 2012;55:230–4.PubMedCrossRef
34.
go back to reference Groote D. Naso-oesophageal probes decrease the frequency of sleep apnoeas in infants. J Sleep Res. 2000;9:193–6.PubMedCrossRef Groote D. Naso-oesophageal probes decrease the frequency of sleep apnoeas in infants. J Sleep Res. 2000;9:193–6.PubMedCrossRef
35.
go back to reference Pilic D, Fröhlich T, Nöh F, Pappas A, Schmidt-Choudhury A, Köhler H, , et al. Detection of gastroesophageal reflux in children using combined multichannel intraluminal impedance and pH measurement: data from the German pediatric impedance group. J Pediatr 2011;158:650-654.PubMedCrossRef Pilic D, Fröhlich T, Nöh F, Pappas A, Schmidt-Choudhury A, Köhler H, , et al. Detection of gastroesophageal reflux in children using combined multichannel intraluminal impedance and pH measurement: data from the German pediatric impedance group. J Pediatr 2011;158:650-654.PubMedCrossRef
36.
go back to reference Mousa H, Machado R, Orsi M, Chao CS, Alhajj T, Alhajj M, et al. Combined multichannel intraluminal impedance-pH (MII-pH): multicenter report of normal values from 117 children. Curr Gastroenterol Rep. 2014;16:1–8. Mousa H, Machado R, Orsi M, Chao CS, Alhajj T, Alhajj M, et al. Combined multichannel intraluminal impedance-pH (MII-pH): multicenter report of normal values from 117 children. Curr Gastroenterol Rep. 2014;16:1–8.
37.
go back to reference National Collaborating Centre for Women's and Children's Health (UK). Gastro-Oesophageal Reflux Disease: Recognition, Diagnosis and Management in Children and Young People. National Institute for Health and Care Excellence. 2015. National Collaborating Centre for Women's and Children's Health (UK). Gastro-Oesophageal Reflux Disease: Recognition, Diagnosis and Management in Children and Young People. National Institute for Health and Care Excellence. 2015.
39.
go back to reference Bonkowsky JL, Guenther E, Srivastava R, Filloux FM. Seizures in children following an apparent life-threatening event. J Child Neurol. 2009;24:709–13.PubMedCrossRef Bonkowsky JL, Guenther E, Srivastava R, Filloux FM. Seizures in children following an apparent life-threatening event. J Child Neurol. 2009;24:709–13.PubMedCrossRef
40.
go back to reference Leone MA. Solari a, Beghi E, FIRST Group. Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy. Neurology. 2006;67:2227–9.PubMedCrossRef Leone MA. Solari a, Beghi E, FIRST Group. Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy. Neurology. 2006;67:2227–9.PubMedCrossRef
41.
go back to reference Emery ES. Status epilepticus secondary to breath-holding and pallid syncopal spells. Neurology. 1990;40:859.PubMedCrossRef Emery ES. Status epilepticus secondary to breath-holding and pallid syncopal spells. Neurology. 1990;40:859.PubMedCrossRef
42.
go back to reference Aubourg P, Dulac O, Plouin P, Diebler C. Infantile status epilepticus as a complication of ‘near-miss’ sudden infant death. Dev Med Child Neurol. 1985;27:40–8.PubMedCrossRef Aubourg P, Dulac O, Plouin P, Diebler C. Infantile status epilepticus as a complication of ‘near-miss’ sudden infant death. Dev Med Child Neurol. 1985;27:40–8.PubMedCrossRef
43.
go back to reference Bonkowsky JL, Guenther E, Filloux FM, Srivastava R. Death, child abuse, and adverse neurological outcome of infants after an apparent life-threatening event. Pediatrics. 2008;122:125–31.PubMedCrossRef Bonkowsky JL, Guenther E, Filloux FM, Srivastava R. Death, child abuse, and adverse neurological outcome of infants after an apparent life-threatening event. Pediatrics. 2008;122:125–31.PubMedCrossRef
44.
go back to reference Fuger M, Merdariu D, Maurey H, Kaminska A, Chéron G. Pertinence de la prescription au service d’accueil des urgences d’un électroencéphalogramme après un malaise du nourrisson. Arch Pediatr. 2014;21:1206–12.PubMedCrossRef Fuger M, Merdariu D, Maurey H, Kaminska A, Chéron G. Pertinence de la prescription au service d’accueil des urgences d’un électroencéphalogramme après un malaise du nourrisson. Arch Pediatr. 2014;21:1206–12.PubMedCrossRef
45.
go back to reference Brand DA, Altman RL, Purtill K, Edwards KS. Yield of diagnostic testing in infants who have had an apparent life-threatening event. Pediatrics. 2005;115:885–93.PubMedCrossRef Brand DA, Altman RL, Purtill K, Edwards KS. Yield of diagnostic testing in infants who have had an apparent life-threatening event. Pediatrics. 2005;115:885–93.PubMedCrossRef
46.
go back to reference De Piero AD, Teach SJ, Chamberlain JM. ED evaluation of infants after an apparent life-threatening event. Am J Emerg Med. 2004;22:83–6.PubMedCrossRef De Piero AD, Teach SJ, Chamberlain JM. ED evaluation of infants after an apparent life-threatening event. Am J Emerg Med. 2004;22:83–6.PubMedCrossRef
47.
go back to reference Al Khushi N, Côté A. Apparent life-threatening events: assessment, risks, reality. Paediatr Respir Rev. 2011;12:124–32.PubMedCrossRef Al Khushi N, Côté A. Apparent life-threatening events: assessment, risks, reality. Paediatr Respir Rev. 2011;12:124–32.PubMedCrossRef
48.
go back to reference Baker KA, Ryan ME. RSV infection in infants and young children: What's new in diagnosis, treatment, and prevention? Postgrad Med. 1999;106:97–111.PubMedCrossRef Baker KA, Ryan ME. RSV infection in infants and young children: What's new in diagnosis, treatment, and prevention? Postgrad Med. 1999;106:97–111.PubMedCrossRef
49.
50.
go back to reference Ammenti A, Cataldi L, Chimenz R, Fanos V, La Manna A, Marra G, et al. Febrile urinary tract infections in young children: recommendations for the diagnosis, treatment and follow-up. Acta Paediatr. 2012;101:451–7.PubMedCrossRef Ammenti A, Cataldi L, Chimenz R, Fanos V, La Manna A, Marra G, et al. Febrile urinary tract infections in young children: recommendations for the diagnosis, treatment and follow-up. Acta Paediatr. 2012;101:451–7.PubMedCrossRef
51.
go back to reference Bradley JS, Byington CL, Shah SS, Alverson B, Carter ER, Harrison C, et al. The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis. 2011;53:25–76.CrossRef Bradley JS, Byington CL, Shah SS, Alverson B, Carter ER, Harrison C, et al. The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis. 2011;53:25–76.CrossRef
52.
go back to reference Fancourt N, Deloria Knoll M, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, et al. Chest radiograph findings in childhood pneumonia cases from the multisite PERCH study. Clin Infect Dis. 2017;64:262–70.CrossRef Fancourt N, Deloria Knoll M, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, et al. Chest radiograph findings in childhood pneumonia cases from the multisite PERCH study. Clin Infect Dis. 2017;64:262–70.CrossRef
53.
go back to reference Murphy CG, Van De Pol AC, Harper MB, Bachur RG. Clinical predictors of occult pneumonia in the febrile child. Acad Emerg Med. 2007;14:243–9.PubMedCrossRef Murphy CG, Van De Pol AC, Harper MB, Bachur RG. Clinical predictors of occult pneumonia in the febrile child. Acad Emerg Med. 2007;14:243–9.PubMedCrossRef
54.
go back to reference Zimmerman DR, Kovalski N, Fields S, Lumelsky D, Miron D. Diagnosis of childhood pneumonia: clinical assessment without radiological confirmation may lead to overtreatment. Pediatr Emerg Care. 2012;28:646–9.PubMedCrossRef Zimmerman DR, Kovalski N, Fields S, Lumelsky D, Miron D. Diagnosis of childhood pneumonia: clinical assessment without radiological confirmation may lead to overtreatment. Pediatr Emerg Care. 2012;28:646–9.PubMedCrossRef
55.
go back to reference Zimmerman DR, Kovalski N, Nahir B. Failure to radiologically confirm community-acquired pneumonia means antibiotic overtreatment. Clin Infect Dis. 2012;54:1816.PubMedCrossRef Zimmerman DR, Kovalski N, Nahir B. Failure to radiologically confirm community-acquired pneumonia means antibiotic overtreatment. Clin Infect Dis. 2012;54:1816.PubMedCrossRef
56.
go back to reference Kahn A, Groswasser J, Rebuffat E, Sottiaux M, Blum D, Foerster M, et al. Sleep and cardiorespiratory characteristics of infant victims of sudden death: a prospective case-control study. Sleep. 1992;15:287–92.PubMedCrossRef Kahn A, Groswasser J, Rebuffat E, Sottiaux M, Blum D, Foerster M, et al. Sleep and cardiorespiratory characteristics of infant victims of sudden death: a prospective case-control study. Sleep. 1992;15:287–92.PubMedCrossRef
57.
go back to reference Engelberts AC. The role of obstructive apnea in sudden infant death syndrome and apparent life threatening event. Int J Pediatr Otorhinolaryngol. 1995;32:59–62.CrossRef Engelberts AC. The role of obstructive apnea in sudden infant death syndrome and apparent life threatening event. Int J Pediatr Otorhinolaryngol. 1995;32:59–62.CrossRef
58.
go back to reference Tishler PV, Redline S, Ferrette V, Hans MG, Altose MD. The association of sudden unexpected infant death with obstructive sleep apnea. Am J Respir Crit Care Med. 1996;153:1857–63.PubMedCrossRef Tishler PV, Redline S, Ferrette V, Hans MG, Altose MD. The association of sudden unexpected infant death with obstructive sleep apnea. Am J Respir Crit Care Med. 1996;153:1857–63.PubMedCrossRef
59.
go back to reference Guilleminault C, Pelayo R, Leger D, Philip P, Ohayon M. Sleep-disordered breathing and upper-airway anomalies in first-degree relatives of ALTE children. Pediatr Res. 2001;50:14–22.PubMedCrossRef Guilleminault C, Pelayo R, Leger D, Philip P, Ohayon M. Sleep-disordered breathing and upper-airway anomalies in first-degree relatives of ALTE children. Pediatr Res. 2001;50:14–22.PubMedCrossRef
60.
go back to reference McNamara F, Sullivan CE. Obstructive sleep apnea in infants: relation to family history of sudden infant death syndrome, apparent life-threatening events, and obstructive sleep apnea. J Pediatr. 2000;136:318–23.PubMedCrossRef McNamara F, Sullivan CE. Obstructive sleep apnea in infants: relation to family history of sudden infant death syndrome, apparent life-threatening events, and obstructive sleep apnea. J Pediatr. 2000;136:318–23.PubMedCrossRef
61.
go back to reference Poets CF. Apparent life-threatening events (ALTE) or brief resolved unexplained events (BRUE). J Paediatr Child Health. 2017;27:215–21.CrossRef Poets CF. Apparent life-threatening events (ALTE) or brief resolved unexplained events (BRUE). J Paediatr Child Health. 2017;27:215–21.CrossRef
62.
go back to reference Rabasco J, Vigo A, Vitelli O, Noce S, Pietropaoli N, Evangelisti M, et al. Apparent life-threatening events could be a wake-up call for sleep disordered breathing. Pediatr Pulmonol. 2016;51:1403–8.PubMedCrossRef Rabasco J, Vigo A, Vitelli O, Noce S, Pietropaoli N, Evangelisti M, et al. Apparent life-threatening events could be a wake-up call for sleep disordered breathing. Pediatr Pulmonol. 2016;51:1403–8.PubMedCrossRef
63.
go back to reference Aurora RN, Zak RS, Karippot A, Lamm CI, Morgenthaler TI, Auerbach SH, et al. Practice parameters for the respiratory indications for polysomnography in children. Sleep. 2011;34:379–88.PubMedPubMedCentralCrossRef Aurora RN, Zak RS, Karippot A, Lamm CI, Morgenthaler TI, Auerbach SH, et al. Practice parameters for the respiratory indications for polysomnography in children. Sleep. 2011;34:379–88.PubMedPubMedCentralCrossRef
64.
go back to reference Lucet V, De Bethmann O, Denjoy I. Paroxysmal vagal overactivity, apparent life-threatening event and sudden infant death. Neonatology. 2000;78:1–7.CrossRef Lucet V, De Bethmann O, Denjoy I. Paroxysmal vagal overactivity, apparent life-threatening event and sudden infant death. Neonatology. 2000;78:1–7.CrossRef
65.
go back to reference Poets CF, Samuels MP, Southall DP. Potential role of intrapulmonary shunting in the genesis of hypoxemic episodes in infants and young children. Pediatrics. 1992;90:385–91.PubMed Poets CF, Samuels MP, Southall DP. Potential role of intrapulmonary shunting in the genesis of hypoxemic episodes in infants and young children. Pediatrics. 1992;90:385–91.PubMed
66.
go back to reference Lombroso CT, Lerman P. Breathholding spells (cyanotic and pallid infantile syncope). Pediatrics. 1967;39:563–81.PubMed Lombroso CT, Lerman P. Breathholding spells (cyanotic and pallid infantile syncope). Pediatrics. 1967;39:563–81.PubMed
67.
go back to reference Daoud AS, Batieha A, Al-Sheyyab M, Abuekteish F, Hijazi SA. Effectiveness of iron therapy on breath-holding spells. J Pediatr. 1997;130:547–50.PubMedCrossRef Daoud AS, Batieha A, Al-Sheyyab M, Abuekteish F, Hijazi SA. Effectiveness of iron therapy on breath-holding spells. J Pediatr. 1997;130:547–50.PubMedCrossRef
68.
go back to reference Vurucu S, Karaoglu A, Paksu SM, Oz O, Yaman H, Gulgun M, et al. Breath-holding spells may be associated with maturational delay in myelination of brain stem. J Clin Neurophysiol. 2014;31:99–101.PubMedCrossRef Vurucu S, Karaoglu A, Paksu SM, Oz O, Yaman H, Gulgun M, et al. Breath-holding spells may be associated with maturational delay in myelination of brain stem. J Clin Neurophysiol. 2014;31:99–101.PubMedCrossRef
69.
go back to reference Yılmaz U, Doksöz Ö, Yılmaz TS, Çelik T, Akıncı G, Mese T. The value of neurologic and cardiologic assessment in breath holding spells. Pak J Med Sci. 2013;130:59–64. Yılmaz U, Doksöz Ö, Yılmaz TS, Çelik T, Akıncı G, Mese T. The value of neurologic and cardiologic assessment in breath holding spells. Pak J Med Sci. 2013;130:59–64.
70.
go back to reference Weese-Mayer DE, Berry-Kravis EM, Ceccherini I, Keens TG, Loghmanee DA, Trang H. An official ATS clinical policy statement: congenital central hypoventilation syndrome: genetic basis, diagnosis, and management. Am J Respir Crit Care Med. 2010;181:626–44.PubMedCrossRef Weese-Mayer DE, Berry-Kravis EM, Ceccherini I, Keens TG, Loghmanee DA, Trang H. An official ATS clinical policy statement: congenital central hypoventilation syndrome: genetic basis, diagnosis, and management. Am J Respir Crit Care Med. 2010;181:626–44.PubMedCrossRef
71.
go back to reference Takahashi T, Yamada K, Kobayashi H, Hasegawa Y, Taketani T, Fukuda S, et al. Metabolic disease in 10 patients with sudden unexpected death in infancy or acute life-threatening events. Pediatr Int. 2015;57:348–53.PubMedCrossRef Takahashi T, Yamada K, Kobayashi H, Hasegawa Y, Taketani T, Fukuda S, et al. Metabolic disease in 10 patients with sudden unexpected death in infancy or acute life-threatening events. Pediatr Int. 2015;57:348–53.PubMedCrossRef
72.
go back to reference Schwartz PJ, Stramba-Badiale M, Segantini A, Austoni P, Bosi G, Giorgetti R, et al. Prolongation of the QT interval and the sudden infant death syndrome. N Engl J Med. 1998;338:1709–14.PubMedCrossRef Schwartz PJ, Stramba-Badiale M, Segantini A, Austoni P, Bosi G, Giorgetti R, et al. Prolongation of the QT interval and the sudden infant death syndrome. N Engl J Med. 1998;338:1709–14.PubMedCrossRef
73.
go back to reference Schwartz PJ, Priori SG, Dumaine R, Napolitano C, Antzelevitch C, Stramba-Badiale M, et al. A molecular link between the sudden infant death syndrome and the long-QT syndrome. N Engl J Med. 2000;343:262–7.PubMedCrossRef Schwartz PJ, Priori SG, Dumaine R, Napolitano C, Antzelevitch C, Stramba-Badiale M, et al. A molecular link between the sudden infant death syndrome and the long-QT syndrome. N Engl J Med. 2000;343:262–7.PubMedCrossRef
75.
go back to reference Schwartz PJ, Stramba-Badiale M, Crotti L, Pedrazzini M, Besana A, Bosi G, et al. Prevalence of the congenital long-QT syndrome. Circulation. 2009;120:1761–7.PubMedPubMedCentralCrossRef Schwartz PJ, Stramba-Badiale M, Crotti L, Pedrazzini M, Besana A, Bosi G, et al. Prevalence of the congenital long-QT syndrome. Circulation. 2009;120:1761–7.PubMedPubMedCentralCrossRef
76.
go back to reference Elias MD, Iyer VR, Cohen MS. Prevalence of electrocardiogram use in infants with apparent life-threatening events: a multicenter database study. Pediatr Emerg Care. 2014;30:236–9.PubMedCrossRef Elias MD, Iyer VR, Cohen MS. Prevalence of electrocardiogram use in infants with apparent life-threatening events: a multicenter database study. Pediatr Emerg Care. 2014;30:236–9.PubMedCrossRef
77.
go back to reference Hoki R, Bonkowsky JL, Minich LL, Srivastava R, Pinto NM. Cardiac testing and outcomes in infants after an apparent life-threatening event. Arch Dis Child. 2012;97:1034–8.PubMedCrossRef Hoki R, Bonkowsky JL, Minich LL, Srivastava R, Pinto NM. Cardiac testing and outcomes in infants after an apparent life-threatening event. Arch Dis Child. 2012;97:1034–8.PubMedCrossRef
78.
go back to reference Hunt CE. Abnormal hypercarbic and hypoxic sleep arousal responses in near-miss SIDS infants. Pediatr Res. 1981;15:1462–4.PubMedCrossRef Hunt CE. Abnormal hypercarbic and hypoxic sleep arousal responses in near-miss SIDS infants. Pediatr Res. 1981;15:1462–4.PubMedCrossRef
79.
go back to reference Hunt CE, Brouillette RT, Hanson D. Theophylline improves pneumogram abnormalities in infants at risk for sudden infant death syndrome. J Pediatr. 1983;103:969–74.PubMedCrossRef Hunt CE, Brouillette RT, Hanson D. Theophylline improves pneumogram abnormalities in infants at risk for sudden infant death syndrome. J Pediatr. 1983;103:969–74.PubMedCrossRef
80.
go back to reference Kelly DH, Shannon DC. Periodic breathing in infants with near-miss sudden infant death syndrome. Pediatrics. 1979;63:355–60.PubMed Kelly DH, Shannon DC. Periodic breathing in infants with near-miss sudden infant death syndrome. Pediatrics. 1979;63:355–60.PubMed
81.
go back to reference Gozal D. New concepts in abnormalities of respiratory control in children. Curr Opin Pediatr. 2004;16:305–8.PubMedCrossRef Gozal D. New concepts in abnormalities of respiratory control in children. Curr Opin Pediatr. 2004;16:305–8.PubMedCrossRef
82.
go back to reference Wasilewska J, Sienkiewicz-Szłapka E, Kuźbida E, Jarmołowska B, Kaczmarski M, Kostyra E. The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE). Neuropeptides. 2011;45:189–95.PubMedCrossRef Wasilewska J, Sienkiewicz-Szłapka E, Kuźbida E, Jarmołowska B, Kaczmarski M, Kostyra E. The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE). Neuropeptides. 2011;45:189–95.PubMedCrossRef
83.
go back to reference Hartmann H, Seidenberg J, Noyes JP, O'Brien L, Poets CF, Samuels MP, et al. Small airway patency in infants with apparent life-threatening events. Eur J Pediatr. 1998;157:71–4.PubMedCrossRef Hartmann H, Seidenberg J, Noyes JP, O'Brien L, Poets CF, Samuels MP, et al. Small airway patency in infants with apparent life-threatening events. Eur J Pediatr. 1998;157:71–4.PubMedCrossRef
84.
go back to reference Horemuzova E, Katz-Salamon M, Milerad J. Increased inspiratory effort in infants with a history of apparent life-threatening event. Acta Paediatr. 2002;91:280–6.PubMedCrossRef Horemuzova E, Katz-Salamon M, Milerad J. Increased inspiratory effort in infants with a history of apparent life-threatening event. Acta Paediatr. 2002;91:280–6.PubMedCrossRef
85.
go back to reference Cornwell AC, Laxminarayan S. A sleep disturbance in high risk for SIDS infants. J Sleep Res. 1993;2:110–4.PubMedCrossRef Cornwell AC, Laxminarayan S. A sleep disturbance in high risk for SIDS infants. J Sleep Res. 1993;2:110–4.PubMedCrossRef
86.
go back to reference Miano S, Castaldo R, Ferri R, Peraita-Adrados R, Paolino MC, Montesano M, et al. Sleep cyclic alternating pattern analysis in infants with apparent life-threatening events: a daytime polysomnographic study. Clin Neurophysiol. 2012;123:1346–52.PubMedCrossRef Miano S, Castaldo R, Ferri R, Peraita-Adrados R, Paolino MC, Montesano M, et al. Sleep cyclic alternating pattern analysis in infants with apparent life-threatening events: a daytime polysomnographic study. Clin Neurophysiol. 2012;123:1346–52.PubMedCrossRef
87.
go back to reference Ruggins NR, Milner AD. Site of upper airway obstruction in infants following an acute life-threatening event. Pediatrics. 1993;91:595–601.PubMed Ruggins NR, Milner AD. Site of upper airway obstruction in infants following an acute life-threatening event. Pediatrics. 1993;91:595–601.PubMed
88.
go back to reference Horn MH, Kinnamon DD, Ferraro N, Curley MA. Smaller mandibular size in infants with a history of an apparent life-threatening event. J Pediatr. 2006;149:499–504.PubMedCrossRef Horn MH, Kinnamon DD, Ferraro N, Curley MA. Smaller mandibular size in infants with a history of an apparent life-threatening event. J Pediatr. 2006;149:499–504.PubMedCrossRef
89.
go back to reference Harrington C, Kirjavainen T, Teng A, Sullivan CE. Altered autonomic function and reduced arousability in apparent life-threatening event infants with obstructive sleep apnea. Am J Respir Crit Care Med. 2002;165:1048–54.PubMedCrossRef Harrington C, Kirjavainen T, Teng A, Sullivan CE. Altered autonomic function and reduced arousability in apparent life-threatening event infants with obstructive sleep apnea. Am J Respir Crit Care Med. 2002;165:1048–54.PubMedCrossRef
90.
go back to reference Filonzi L, Magnani C, Nosetti L, Nespoli L, Borghi C, Vaghi M, et al. Serotonin transporter role in identifying similarities between SIDS and idiopathic ALTE. Pediatrics. 2012;130:138–44.CrossRef Filonzi L, Magnani C, Nosetti L, Nespoli L, Borghi C, Vaghi M, et al. Serotonin transporter role in identifying similarities between SIDS and idiopathic ALTE. Pediatrics. 2012;130:138–44.CrossRef
91.
go back to reference Hall KL, Zalman B. Evaluation and management of apparent life-threatening events in children. Am Fam Physician. 2005;71:2301–8.PubMed Hall KL, Zalman B. Evaluation and management of apparent life-threatening events in children. Am Fam Physician. 2005;71:2301–8.PubMed
92.
go back to reference Blackmon LR, Batton DG, Bell EF, Engle WA, Kanto WP, Martin GI, et al. Apnea, sudden infant death syndrome, and home monitoring. Pediatrics. 2003;111:914–7.CrossRef Blackmon LR, Batton DG, Bell EF, Engle WA, Kanto WP, Martin GI, et al. Apnea, sudden infant death syndrome, and home monitoring. Pediatrics. 2003;111:914–7.CrossRef
93.
go back to reference Ramanathan R, Corwin MJ, Hunt CE, Lister G, Tinsley LR, Baird T, et al. Cardiorespiratory events recorded on home monitors: comparison of healthy infants with those at increased risk for SIDS. JAMA. 2001;285:2199–207.PubMedCrossRef Ramanathan R, Corwin MJ, Hunt CE, Lister G, Tinsley LR, Baird T, et al. Cardiorespiratory events recorded on home monitors: comparison of healthy infants with those at increased risk for SIDS. JAMA. 2001;285:2199–207.PubMedCrossRef
95.
go back to reference Claudius I, Keens T. Do all infants with apparent life-threatening events need to be admitted? Pediatrics. 2007;119:679–83.PubMedCrossRef Claudius I, Keens T. Do all infants with apparent life-threatening events need to be admitted? Pediatrics. 2007;119:679–83.PubMedCrossRef
96.
go back to reference Hoppenbrouwers T, Hodgman JE, Ramanathan A, Dorey F. Extreme and conventional cardiorespiratory events and epidemiologic risk factors for SIDS. J Pediatr. 2008;152:636–41.PubMedCrossRef Hoppenbrouwers T, Hodgman JE, Ramanathan A, Dorey F. Extreme and conventional cardiorespiratory events and epidemiologic risk factors for SIDS. J Pediatr. 2008;152:636–41.PubMedCrossRef
97.
go back to reference Tal Y, Tirosh E, Even L, Jaffe M. A comparison of the yield of a 24 h versus 72 h hospital evaluation in infants with apparent life-threatening events. Eur J Pediatr. 1999;158:954.PubMedCrossRef Tal Y, Tirosh E, Even L, Jaffe M. A comparison of the yield of a 24 h versus 72 h hospital evaluation in infants with apparent life-threatening events. Eur J Pediatr. 1999;158:954.PubMedCrossRef
98.
go back to reference Stratton SJ, Taves A, Lewis RJ, Clements H, Henderson D, McCollough M. Apparent life-threatening events in infants: high risk in the out-of-hospital environment. Ann Emerg Med. 2004;43:711–7.PubMedCrossRef Stratton SJ, Taves A, Lewis RJ, Clements H, Henderson D, McCollough M. Apparent life-threatening events in infants: high risk in the out-of-hospital environment. Ann Emerg Med. 2004;43:711–7.PubMedCrossRef
99.
go back to reference Ueda R, Nomura O, Maekawa T, Sakai H, Nakagawa S, Ishiguro A. Independent risk factors for recurrence of apparent life-threatening events in infants. Eur J Pediatr. 2017;176:443–8.PubMedCrossRef Ueda R, Nomura O, Maekawa T, Sakai H, Nakagawa S, Ishiguro A. Independent risk factors for recurrence of apparent life-threatening events in infants. Eur J Pediatr. 2017;176:443–8.PubMedCrossRef
100.
go back to reference Côté A, Hum C, Brouillette RT, Themens M. Frequency and timing of recurrent events in infants using home cardiorespiratory monitors. J Pediatr. 1998;132:783–9.PubMedCrossRef Côté A, Hum C, Brouillette RT, Themens M. Frequency and timing of recurrent events in infants using home cardiorespiratory monitors. J Pediatr. 1998;132:783–9.PubMedCrossRef
101.
go back to reference Côté A. Home and hospital monitoring for ALTE. Paediatr Respir Rev. 2006;7:199–201.CrossRef Côté A. Home and hospital monitoring for ALTE. Paediatr Respir Rev. 2006;7:199–201.CrossRef
102.
go back to reference DeWolfe CC. Apparent life-threatening event: a review. Pediatr Clin N Am. 2005;52:1127–46.CrossRef DeWolfe CC. Apparent life-threatening event: a review. Pediatr Clin N Am. 2005;52:1127–46.CrossRef
103.
go back to reference Poets CF, Samuels MP, Noyes JP, Hewertson J, Hartmann H, Holder A, et al. Home event recordings of oxygenation, breathing movements, and heart rate and rhythm in infants with recurrent life-threatening events. J Pediatr. 1993;123:693–701.PubMedCrossRef Poets CF, Samuels MP, Noyes JP, Hewertson J, Hartmann H, Holder A, et al. Home event recordings of oxygenation, breathing movements, and heart rate and rhythm in infants with recurrent life-threatening events. J Pediatr. 1993;123:693–701.PubMedCrossRef
104.
go back to reference Poets CF. Apparent life-threatening events and sudden infant death on a monitor. Paediatr Respir Rev. 2004;5:383–6.CrossRef Poets CF. Apparent life-threatening events and sudden infant death on a monitor. Paediatr Respir Rev. 2004;5:383–6.CrossRef
105.
go back to reference Nassi N, Piumelli R, Lombardi E, Landini L, Donzelli G, de Martino M. Comparison between pulse oximetry and transthoracic impedance alarm traces during home monitoring. Arch Dis Child. 2008;93:126–32.PubMedCrossRef Nassi N, Piumelli R, Lombardi E, Landini L, Donzelli G, de Martino M. Comparison between pulse oximetry and transthoracic impedance alarm traces during home monitoring. Arch Dis Child. 2008;93:126–32.PubMedCrossRef
106.
go back to reference Al-Kindy HA, Gélinas JF, Hatzakis G, Côté A. Risk factors for extreme events in infants hospitalized for apparent life-threatening events. J Pediatr. 2009;154:332–7.PubMedCrossRef Al-Kindy HA, Gélinas JF, Hatzakis G, Côté A. Risk factors for extreme events in infants hospitalized for apparent life-threatening events. J Pediatr. 2009;154:332–7.PubMedCrossRef
107.
go back to reference Halbower AC. Pediatric home apnea monitors: coding, billing, and updated prescribing information for practice management. Chest. 2008;134:425–9.PubMedCrossRef Halbower AC. Pediatric home apnea monitors: coding, billing, and updated prescribing information for practice management. Chest. 2008;134:425–9.PubMedCrossRef
108.
go back to reference Horne RS, Nixon GM. The role of physiological studies and apnoea monitoring in infants. Paediatr Respir Rev. 2014;15:312–8.PubMed Horne RS, Nixon GM. The role of physiological studies and apnoea monitoring in infants. Paediatr Respir Rev. 2014;15:312–8.PubMed
109.
go back to reference Brockmann VP, Abara ES, Campos OC, Holmgren PN, Montes FS, Sepúlveda RH, et al. Consensus on evaluation and management of apparent life-threatening events in infancy (ALTE). Rev Chil Pediatr. 2014;85:378–87.CrossRef Brockmann VP, Abara ES, Campos OC, Holmgren PN, Montes FS, Sepúlveda RH, et al. Consensus on evaluation and management of apparent life-threatening events in infancy (ALTE). Rev Chil Pediatr. 2014;85:378–87.CrossRef
110.
111.
go back to reference Silvestri JM, Hufford DR, Durham J, Pearsall SM, Oess MA, Weese-Mayer DE, et al. Assessment of compliance with home cardiorespiratory monitoring in infants at risk of sudden infant death syndrome. J Pediatr. 1995;127:384–8.PubMedCrossRef Silvestri JM, Hufford DR, Durham J, Pearsall SM, Oess MA, Weese-Mayer DE, et al. Assessment of compliance with home cardiorespiratory monitoring in infants at risk of sudden infant death syndrome. J Pediatr. 1995;127:384–8.PubMedCrossRef
113.
go back to reference Hunt CE, Hufford DR, Bourguignon C, Oess MA. Home documented monitoring of Cardiorespiratory pattern and oxygen saturation in healthy Infants1. Pediatr Res. 1996;39:216–22.PubMedCrossRef Hunt CE, Hufford DR, Bourguignon C, Oess MA. Home documented monitoring of Cardiorespiratory pattern and oxygen saturation in healthy Infants1. Pediatr Res. 1996;39:216–22.PubMedCrossRef
114.
go back to reference Hunt CE, Corwin MJ, Lister G, Weese-Mayer DE, Ward SLD, Tinsley LR, et al. Precursors of cardiorespiratory events in infants detected by home memory monitor. Pediatr Pulmonol. 2008;43:87–98.PubMedCrossRef Hunt CE, Corwin MJ, Lister G, Weese-Mayer DE, Ward SLD, Tinsley LR, et al. Precursors of cardiorespiratory events in infants detected by home memory monitor. Pediatr Pulmonol. 2008;43:87–98.PubMedCrossRef
115.
116.
go back to reference Moon RY, AAP Task Force on Sudden Infant Death Syndrome. SIDS and other sleep-related infant deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment. Pediatrics. 2016; 138. pii: e20162940. Moon RY, AAP Task Force on Sudden Infant Death Syndrome. SIDS and other sleep-related infant deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment. Pediatrics. 2016; 138. pii: e20162940.
117.
go back to reference Hunt CE, Corwin MJ, Baird T, Tinsley LR, Palmer P, Ramanathan R, et al. Cardiorespiratory events detected by home memory monitoring and one-year neurodevelopmental outcome. J Pediatr. 2004;145:465–71.PubMedCrossRef Hunt CE, Corwin MJ, Baird T, Tinsley LR, Palmer P, Ramanathan R, et al. Cardiorespiratory events detected by home memory monitoring and one-year neurodevelopmental outcome. J Pediatr. 2004;145:465–71.PubMedCrossRef
118.
go back to reference Brooks JG. Apparent life-threatening events and apnea of infancy. Clin Perinatol. 1992;19:809–38.PubMed Brooks JG. Apparent life-threatening events and apnea of infancy. Clin Perinatol. 1992;19:809–38.PubMed
119.
120.
go back to reference Hashimoto Y, Moriya F, Furumiya J. Forensic aspects of complications resulting from cardiopulmonary resuscitation. Leg Med (Tokyo). 2007;9:94–9.CrossRef Hashimoto Y, Moriya F, Furumiya J. Forensic aspects of complications resulting from cardiopulmonary resuscitation. Leg Med (Tokyo). 2007;9:94–9.CrossRef
121.
go back to reference Steiman B, Watemberg N. Apparent life-threatening events: Patients' health status at 5 years of age. Isr Med Assoc J. 2015;17:673–7.PubMed Steiman B, Watemberg N. Apparent life-threatening events: Patients' health status at 5 years of age. Isr Med Assoc J. 2015;17:673–7.PubMed
122.
go back to reference Parker K, Pitetti R. Mortality and child abuse in children presenting with apparent life-threatening events. Pediatr Emerg Care. 2011;27:591–5.PubMedCrossRef Parker K, Pitetti R. Mortality and child abuse in children presenting with apparent life-threatening events. Pediatr Emerg Care. 2011;27:591–5.PubMedCrossRef
123.
go back to reference Guenther E, Powers A, Srivastava R, Bonkowsky JL. Abusive head trauma in children presenting with an apparent life-threatening event. J Pediatr. 2010;57:821–5.CrossRef Guenther E, Powers A, Srivastava R, Bonkowsky JL. Abusive head trauma in children presenting with an apparent life-threatening event. J Pediatr. 2010;57:821–5.CrossRef
124.
go back to reference Kant S, Fisher JD, Nelson DG, Khan S. Mortality after discharge in clinically stable infants admitted with a first-time apparent life-threatening event. Am J Emerg Med. 2013;31:730–3.PubMedCrossRef Kant S, Fisher JD, Nelson DG, Khan S. Mortality after discharge in clinically stable infants admitted with a first-time apparent life-threatening event. Am J Emerg Med. 2013;31:730–3.PubMedCrossRef
125.
go back to reference Waite AJ, Coombs RC, McKenzie A, Daman-Willems C, Cohen MC, Campbell MJ, et al. Mortality of babies enrolled in a community-based support programme: CONI PLUS (Care of Next Infant Plus). Arch Dis Child. 2015;100:637–42.PubMedCrossRef Waite AJ, Coombs RC, McKenzie A, Daman-Willems C, Cohen MC, Campbell MJ, et al. Mortality of babies enrolled in a community-based support programme: CONI PLUS (Care of Next Infant Plus). Arch Dis Child. 2015;100:637–42.PubMedCrossRef
126.
go back to reference Kahn A, Sottiaux M, Appelboom-Fondu J, Blum D, Rebuffat E, Levitt J. Long-term development of children monitored as infants for an apparent life-threatening event during sleep: a 10-year follow-up study. Pediatrics. 1989;83:668–73.PubMed Kahn A, Sottiaux M, Appelboom-Fondu J, Blum D, Rebuffat E, Levitt J. Long-term development of children monitored as infants for an apparent life-threatening event during sleep: a 10-year follow-up study. Pediatrics. 1989;83:668–73.PubMed
127.
go back to reference Biarent D, Bingham R, Richmond S, Maconochie I, Wyllie J, Simpson S, et al. European resuscitation council guidelines for resuscitation 2005. Resuscitation. 2005;67:97–133.CrossRef Biarent D, Bingham R, Richmond S, Maconochie I, Wyllie J, Simpson S, et al. European resuscitation council guidelines for resuscitation 2005. Resuscitation. 2005;67:97–133.CrossRef
128.
go back to reference Palmieri A, Riccardi S, Bergamino L, Ciccone MO, Fornoni L, Piccotti E, et al. Apparent life threatening event (ALTE): the role of the training in the follow-up. Minerva Pediatr. 2011;63:139–48.PubMed Palmieri A, Riccardi S, Bergamino L, Ciccone MO, Fornoni L, Piccotti E, et al. Apparent life threatening event (ALTE): the role of the training in the follow-up. Minerva Pediatr. 2011;63:139–48.PubMed
129.
go back to reference Shah S, Sharieff GQ. An update on the approach to apparent life-threatening events. Curr Opin Pediatr. 2007;19:288–94.PubMedCrossRef Shah S, Sharieff GQ. An update on the approach to apparent life-threatening events. Curr Opin Pediatr. 2007;19:288–94.PubMedCrossRef
130.
go back to reference Piumelli R. SIDS: Conoscerla per ridurne il rischio. Cento: Editeam; 2008. Piumelli R. SIDS: Conoscerla per ridurne il rischio. Cento: Editeam; 2008.
131.
go back to reference Carpenter RG, Irgens LM, Blair PS, England PD, Fleming P, Huber J, et al. Sudden unexplained infant death in 20 regions in Europe: case control study. Lancet Neurol. 2004;363:185–91.CrossRef Carpenter RG, Irgens LM, Blair PS, England PD, Fleming P, Huber J, et al. Sudden unexplained infant death in 20 regions in Europe: case control study. Lancet Neurol. 2004;363:185–91.CrossRef
132.
go back to reference Edner A, Wennborg M, Alm B, Lagercrantz H. Why do ALTE infants not die in SIDS? Acta Paediatr. 2007;96:191–4.PubMedCrossRef Edner A, Wennborg M, Alm B, Lagercrantz H. Why do ALTE infants not die in SIDS? Acta Paediatr. 2007;96:191–4.PubMedCrossRef
133.
go back to reference Esani N, Hodgman JE, Ehsani N, Hoppenbrouwers T. Apparent life-threatening events and sudden infant death syndrome: comparison of risk factors. J Pediatr. 2008;152:365–70.PubMedCrossRef Esani N, Hodgman JE, Ehsani N, Hoppenbrouwers T. Apparent life-threatening events and sudden infant death syndrome: comparison of risk factors. J Pediatr. 2008;152:365–70.PubMedCrossRef
134.
go back to reference Klintschar M, Heimbold C. Association between a functional polymorphism in the MAOA gene and sudden infant death syndrome. Pediatrics. 2012;129:756–61.CrossRef Klintschar M, Heimbold C. Association between a functional polymorphism in the MAOA gene and sudden infant death syndrome. Pediatrics. 2012;129:756–61.CrossRef
136.
go back to reference Grylack LJ, Williams AD. Apparent life-threatening events in presumed healthy neonates during the first three days of life. Pediatrics. 1996;97:349–51.PubMed Grylack LJ, Williams AD. Apparent life-threatening events in presumed healthy neonates during the first three days of life. Pediatrics. 1996;97:349–51.PubMed
137.
go back to reference Herlenius E, Kuhn P. Sudden unexpected postnatal collapse of newborn infants: a review of cases, definitions, risks, and preventive measures. Transl Stroke Res. 2013;4:236–7.PubMedPubMedCentralCrossRef Herlenius E, Kuhn P. Sudden unexpected postnatal collapse of newborn infants: a review of cases, definitions, risks, and preventive measures. Transl Stroke Res. 2013;4:236–7.PubMedPubMedCentralCrossRef
138.
go back to reference Becher JC, Bhushan SS, Lyon AJ. Unexpected collapse in apparently healthy newborns–a prospective national study of a missing cohort of neonatal deaths and near-death events. Arch Dis Child Fetal Neonatal Ed. 2012;97:30–4.CrossRef Becher JC, Bhushan SS, Lyon AJ. Unexpected collapse in apparently healthy newborns–a prospective national study of a missing cohort of neonatal deaths and near-death events. Arch Dis Child Fetal Neonatal Ed. 2012;97:30–4.CrossRef
139.
go back to reference Peters C, Becher JC, Lyon AJ, Midgley PC. Who is blaming the baby? Arch Dis Child Fetal Neonatal Ed. 2009;94:377–8. Peters C, Becher JC, Lyon AJ, Midgley PC. Who is blaming the baby? Arch Dis Child Fetal Neonatal Ed. 2009;94:377–8.
140.
go back to reference Poets A, Steinfeldt R, Poets CF. Sudden deaths and severe apparent life-threatening events in term infants within 24 hours of birth. Pediatrics. 2011;127:869–73.CrossRef Poets A, Steinfeldt R, Poets CF. Sudden deaths and severe apparent life-threatening events in term infants within 24 hours of birth. Pediatrics. 2011;127:869–73.CrossRef
141.
go back to reference Lutz TL, Elliott EJ, Jeffery HE. Sudden unexplained early neonatal death or collapse: a national surveillance study. Pediatr Res. 2016;80:493–8.PubMedCrossRef Lutz TL, Elliott EJ, Jeffery HE. Sudden unexplained early neonatal death or collapse: a national surveillance study. Pediatr Res. 2016;80:493–8.PubMedCrossRef
142.
go back to reference Weber MA, Ashworth MT, Risdon RA, Brooke I, Malone M, Sebire NJ. Sudden unexpected neonatal death in the first week of life: autopsy findings from a specialist centre. J Matern Fetal Neonatal Med. 2009;22:398–404.PubMedCrossRef Weber MA, Ashworth MT, Risdon RA, Brooke I, Malone M, Sebire NJ. Sudden unexpected neonatal death in the first week of life: autopsy findings from a specialist centre. J Matern Fetal Neonatal Med. 2009;22:398–404.PubMedCrossRef
143.
go back to reference Pejovic NJ, Herlenius E. Unexpected collapse of healthy newborn infants: risk factors, supervision and hypothermia treatment. Acta Paediatr. 2013;102:680–8.PubMedPubMedCentralCrossRef Pejovic NJ, Herlenius E. Unexpected collapse of healthy newborn infants: risk factors, supervision and hypothermia treatment. Acta Paediatr. 2013;102:680–8.PubMedPubMedCentralCrossRef
144.
go back to reference Poets A, Urschitz MS, Steinfeldt R, Poets CF. Risk factors for early sudden deaths and severe apparent life-threatening events. Arch Dis Child Fetal Neonatal Ed. 2012;97:395–7.CrossRef Poets A, Urschitz MS, Steinfeldt R, Poets CF. Risk factors for early sudden deaths and severe apparent life-threatening events. Arch Dis Child Fetal Neonatal Ed. 2012;97:395–7.CrossRef
145.
go back to reference Feldman-Winter L, Goldsmith JP, Task force on sudden infant death syndrome. Safe Sleep and Skin-to-Skin Care in the Neonatal Period for Healthy Term Newborns. Pediatrics. 2016; doi:10.1542/peds.2016-1889. Feldman-Winter L, Goldsmith JP, Task force on sudden infant death syndrome. Safe Sleep and Skin-to-Skin Care in the Neonatal Period for Healthy Term Newborns. Pediatrics. 2016; doi:10.​1542/​peds.​2016-1889.
147.
go back to reference Ludington-Hoe SM, Morgan K. Infant assessment and reduction of sudden unexpected postnatal collapse risk during skin-to-skin contact. Newborn Infant Nurs Rev. 2014;14:28–33.CrossRef Ludington-Hoe SM, Morgan K. Infant assessment and reduction of sudden unexpected postnatal collapse risk during skin-to-skin contact. Newborn Infant Nurs Rev. 2014;14:28–33.CrossRef
148.
go back to reference Davanzo R, De Cunto A, Paviotti G, Travan L, Inglese S, Brovedani P, et al. Making the first days of life safer: preventing sudden unexpected postnatal collapse while promoting breastfeeding. J Hum Lact. 2015;31:47–52.PubMedCrossRef Davanzo R, De Cunto A, Paviotti G, Travan L, Inglese S, Brovedani P, et al. Making the first days of life safer: preventing sudden unexpected postnatal collapse while promoting breastfeeding. J Hum Lact. 2015;31:47–52.PubMedCrossRef
149.
go back to reference Phillips RM, Goldstein M, Hougland K, Nandyal R, Pizzica A, Santa-Donato A, et al. Multidisciplinary guidelines for the care of late preterm infants. J Perinatol. 2013;33:5–22.CrossRef Phillips RM, Goldstein M, Hougland K, Nandyal R, Pizzica A, Santa-Donato A, et al. Multidisciplinary guidelines for the care of late preterm infants. J Perinatol. 2013;33:5–22.CrossRef
150.
go back to reference Scheich B, Bingham D. Key findings from the AWHONN Perinatal staffing data collaborative. J Obstet Gynecol Neonatal Nurs. 2015;44:317–28.PubMedCrossRef Scheich B, Bingham D. Key findings from the AWHONN Perinatal staffing data collaborative. J Obstet Gynecol Neonatal Nurs. 2015;44:317–28.PubMedCrossRef
Metadata
Title
Apparent Life-Threatening Events (ALTE): Italian guidelines
Authors
Raffaele Piumelli
Riccardo Davanzo
Niccolò Nassi
Silvia Salvatore
Cinzia Arzilli
Marta Peruzzi
Massimo Agosti
Antonella Palmieri
Maria Giovanna Paglietti
Luana Nosetti
Raffaele Pomo
Francesco De Luca
Alessandro Rimini
Salvatore De Masi
Simona Costabel
Valeria Cavarretta
Anna Cremante
Fabio Cardinale
Renato Cutrera
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2017
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-017-0429-x

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