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01-04-2004 | Original Article

Apparent bone mineral density estimated from DXA in healthy men and women

Authors: Selma Cvijetić, Mirko Koršić

Published in: Osteoporosis International | Issue 4/2004

Abstract

The aim of this study was to measure bone mineral density (BMD) in healthy people and examine the influence of age, anthropometry, and postmenopause on calculated bone mineral apparent density (BMAD). The study included 541 healthy subjects (249 men and 292 women), aged 20 to 79 years. Anthropometric measurements included height, weight, and body mass index (BMI). Bone mineral content (BMC) and areal BMD were measured at the lumbar spine and proximal femur, using dual-energy X-ray absorptiometry (DXA). The calculation of volumetric density relied on the formula BMAD=BMD/√BA (where BA = bone area). Association between densitometric parameters and age, height, weight, and postmenopause was analyzed with multiple regression. BMC and BMD decreased with age, especially in postmenopausal women. The average annual bone loss in spine was 0.2% in both sexes, whereas femur loss was 0.5% in men and 0.3% in women. Bone area slightly increased with age in both sexes, and BMD loss after the age of 50 could be attributed to bone area increase. To minimize the effect of bone size on bone density, volumetric density and areal density were regressed to age, anthropometry, and postmenopause. Age and postmenopause were significantly associated with BMD and BMAD in the spine and femur. Furthermore, BMD showed a stronger association with height and weight than BMAD, in both regions. Weaker association of body height and weight with BMAD than with BMD suggests that BMD depends on the bone size and body size and that the different BMDs could be the consequence of the difference in those parameters.

Mazess RB, Barden H (1999) Bone density of the spine and femur in adult white females. Calcif Tissue Int 65:91–99CrossRefPubMed

Dougherty G, Al-Marzouk N (2001) Bone density measured by dual energy X-ray absorptiometry in healthy Kuwaiti women. Calcif Tissue Int 68:225–229PubMed

Lehmann R, Wapniarz M, Randerath O et al (1995) Dual energy X-ray absorptiometry at the lumbar spine in German men and women: a cross-sectional study. Calcif Tissue Int 56:350–354PubMed

Löfman O, Larsson L, Ross L, Toss G, Berglund K (1997) Bone mineral density in normal Swedish women. Bone 20:167–174PubMed

Truscott JG, Oldroyd B, Simpson M et al (1993) Variation in lumbar spine and femoral neck bone mineral measured by dual energy X ray absorption: a study of 329 normal women. Br J Radiol 66:514–521PubMed

Blunt BA, Kaluber MR, Barret-Connor EL, Edelstein SL (1994) Sex differences in bone mineral density in 1653 men and women in the sixth through tenth decades of life: the Rancho Bernardo study. J Bone Miner Res 9:1333–1338PubMed

Carter DR, Bouxsein ML, Marcus R (1992) New approaches for interpreting projected bone densitometry data. J Bone Miner Res 7:137–145PubMed

Braillon PM (1999) Volumetric bone mineral density derived from dual-energy X-ray absorptiometry measurements. Nucl Med Commun 20:106PubMed

World Health Organization. (1994) Assessment of risk fracture risk and its association to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser 843:1PubMed

10.

Turek S, Rudan I, Smolej-Narabčić N et al (2001) A large cross-sectional study of health attitudes, knowledge, behaviour and risks in the post-war Croatian population: the First Health Croatian Project. Coll Antropol 25:77–96

11.

Diaz Curiel M, Carrasco de la Pena JL, Honorato Perez J, Perez Cano R, Rapado A, Ruiz Martinez I (1997) Study of bone mineral density in lumbar spine and femoral neck in a Spanish population. Osteoporos Int 7:59–64PubMed

12.

Burger H, van Daele PLA, Algra D et al (1994) The association between age and bone mineral density in men and women aged 55 years and over: the Rotterdam study. Bone Miner 25:1–13

13.

Kröger H, Tuppurainen M, Honkanen R, Alhava E, Saarikoski S (1994) Bone mineral denisty and risk factors for osteoporosis—a population based study of 1600 perimenopausal women. Calcif Tissue Int 55:1–7PubMed

14.

Sowers M, Crutchfield M, Bandekar R et al (1998) Bone mineral density and its change in pre-and perimenopausal white women: the Michigan Bone Health Study. J Bone Miner Res 13:1134–1140PubMed

15.

Norimatsu H, Mori S, Uesato T, Yoshikawa T, Katsuyama N (1989) Bone mineral density of the spine and proximal femur in normal and osteoporotic subjects in Japan. Bone Miner 5:213–222PubMed

16.

Petley GW, Cotton AM, Murrillis AJ et al (1996) Reference ranges of bone mineral density for women in southern England: the impact of local data on the diagnosis of osteoporosis. Br J Radiol 69:655–660PubMed

17.

Looker AC, Wahner HW, Dunn WL et al (1996) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 1998; 8:468–489

18.

Guglielmi G, Giannatempo GM, Blunt BA et al (1995) Current methods and advances in bone densitometry. Eur Radiol 5:269–273

19.

Nilsson M, Johnell O, Jonsson K, Redlund-Johnell I (1988) Quantitative computed tomography in measurement of vertebral trabecular bone mass. A modified method. Acta Radiol 29:719–725PubMed

20.

Compston JE, Evans WD, Crawley EO, Evans C (1988) Bone mineral content in normal UK subjects. Br J Radiol 61:631–636PubMed

21.

Harbison J, Daly L, Murphy B, McCoy C, Masterson J (1992) Normal bone density in Irish women: is American normative data suitable for use in Ireland? Irish J Med Sci 161:66–69PubMed

22.

Michaelsson K, Bergstrom R, Holmberg L, Mallmin H, Wolk A, Ljunghall S (1996) Calcium intake among women aged 40–76 in Sweden. Study Group MRS SWEA (Multiple Risk Survey on Swedish Women for Eating Assessment). J Epidemiol Community Health 50:577–578PubMed

23.

Ensrud KE, Lipschutz RC, Cauley JA et al (1997) Body size and hip fracture risk in older women: a prospective study. Study of Osteoporotic Fractures Research Group. Am J Med 103:274–280CrossRefPubMed

24.

Tsai KS, Cheng WC, Chen CK et al (1997) Effect of bone area on spine density in Chinese men and women in Taiwan. Bone 21:547–551CrossRefPubMed

25.

Jergas M, Breitenseher M, Gluer CC, Yu W, Genant HK (1995) Estimates of volumetric bone density from projectional measurements improve the discriminatory capability of dual X-ray absorptiometry. J Bone Miner Res 10:1101–1110PubMed

26.

Cummings SR, Marcus R, Palermo L, Ensrud KE, Genant HK (1994) Does estimating volumetric bone density of the femoral neck improve the prediction of hip fracture? a prospective study. Study of Osteoporotic Fractures Research Group. J Bone Miner Res 9:1429–1432PubMed

27.

Peel NF, Eastell R (1994) Diagnostic value of estimated volumetric bone mineral density of the lumbar spine in osteoporosis. J Bone Miner Res 9:317–320PubMed

28.

Kalender WA, Felsenberg D, Louis O, et al. Reference values for trabecular and cortical vertebral bone density in single and dual-energy quantitative computed tomography. Europ J Radiol 1989; 9:75–80.

29.

Mazess RB, Barden H, Mautalen C, Vega E (1994) Normalization of spine densitometry. J Bone Miner Res 9:541–548PubMed

Title: Apparent bone mineral density estimated from DXA in healthy men and women
Authors: Selma Cvijetić
Mirko Koršić
Publication date: 01-04-2004
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 4/2004
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-003-1525-x

At a glance: The STEP trials

Springer Medicine

Apparent bone mineral density estimated from DXA in healthy men and women

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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