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International Orthopaedics
Published in: International Orthopaedics 8/2014

01-08-2014 | Original Paper

Apolipoprotein E gene E2/E2 genotype is a genetic risk factor for vertebral fractures in humans: a large-scale study

Authors: Shu Qi Zhang, Wei Ying Zhang, Wen Qin Ye, Ling Juan Zhang, Fan Fan

Published in: International Orthopaedics | Issue 8/2014

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Abstract

Purpose

Although many studies have been performed to evaluate whether or not apolipoprotein E gene (APOE) polymorphisms are differentially associated with bone mineral density (BMD) and fractures, the results have been conflicting. This large-scale study was performed to investigate whether a relationship exists between APOE polymorphisms and risk of fracture.

Methods

A hospital-based case–control study was conducted in 3,000 patients with fractures and 3,000 age- and gender-matched healthy controls. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the APOE gene polymorphisms.

Results

Patients with fractures had a significantly higher frequency of APOE E2/E2 genotype [odds ratio (OR) = 2.02, 95 % confidence interval (CI) = 1.30, 3.14; P = 0.002] than healthy controls. When stratifying by fracture type, it was found that patients with vertebral fractures had a significantly higher frequency of APOE E2/E2 genotype (OR = 2.86, 95 % CI = 1.73, 4.73; P < 0.001). No significant differences were found in nonvertebral (hip or wrist or other) fractures.

Conclusions

Our study suggests that APOE E2/E2 genotype is a potential genetic risk factor for vertebral fractures in humans.
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Metadata
Title
Apolipoprotein E gene E2/E2 genotype is a genetic risk factor for vertebral fractures in humans: a large-scale study
Authors
Shu Qi Zhang
Wei Ying Zhang
Wen Qin Ye
Ling Juan Zhang
Fan Fan
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
International Orthopaedics / Issue 8/2014
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-014-2380-4

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