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Open Access 01-12-2021 | Aortic Valve Replacement | Research article

Surgical techniques for aortic valve xenotransplantation

Authors: Jennie H. Kwon, Morgan Hill, Brielle Gerry, Steven W. Kubalak, Muhammad Mohiuddin, Minoo N. Kavarana, T. Konrad Rajab

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

Background

Heart valve replacement in neonates and infants is one of the remaining unsolved problems in cardiac surgery because conventional valve prostheses do not grow with the children. Similarly, heart valve replacement in children and young adults with contraindications to anticoagulation remains an unsolved problem because mechanical valves are thrombogenic and bioprosthetic valves are prone to early degeneration. Therefore, there is an urgent clinical need for growing heart valve replacements that are durable without the need for anticoagulation.

Methods

A human cadaver model was used to develop surgical techniques for aortic valve xenotransplantation.

Results

Aortic valve xenotransplantation is technically feasible. Subcoronary implantation of the valve avoids the need for a root replacement.

Conclusion

Aortic valve xenotransplantation is promising because the development of GTKO.hCD46.hTBM transgenic pigs has brought xenotransplantation within clinical reach.

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Title: Surgical techniques for aortic valve xenotransplantation
Authors: Jennie H. Kwon
Morgan Hill
Brielle Gerry
Steven W. Kubalak
Muhammad Mohiuddin
Minoo N. Kavarana
T. Konrad Rajab
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Aortic Valve Replacement
Heart Transplantation
Heart Transplantation
Heart Transplantation
Aortic Valve Replacement
Aortic Valve Replacement
Heart Transplantation
Heart Transplantation
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01743-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Surgical techniques for aortic valve xenotransplantation

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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